Sharif Digital Repository

Skin, the largest organ in the body, presents sophisticated functions for maintaining the structural integrity of the entire body. Skin can regulate the temperature of the body, protect the body against microorganisms, have a sensory function, and produce vitamin-D through UV exposure when in direct sunlight.Due to the self-healing property of skin tissue, skin can be repaired by itself. Nevertheless, if extensive skin loss happens, owing to diabetic ulcers or deep burns, skin will not be able to repair the wound by itself. Therefore, it will lose its functions, and the fabrication of a skin equivalent will be necessary. These skin equivalents will cover the wound, regenerate the native... 

Drug targeting to specific organs and tissues has become one of the critical endeavors of the new century. Magnetic nanoparticles have gained a lot of attention in biomedical and industrial application. Doxorubicin is an effective anti-cancer drug in the treatment of many types of cancers. The aim of this study is to load doxorubicin on stimuli-responsive nanocarriers. These nanocarriers are prepared from magnetic nanoparticles. Then these magnetic nanparticles are coated by copolymer of poly(glycidyl methacrylate) then reacted with hydrazine and hydrazide functional group is formed that can chemically be bonded with the anticancer drug doxorubicin via a hydrazone bond formation. This... 

Because of mistakes in the design and calculation, incoherence between construction and design, structural changes, changes in loads and also damages caused by the passage of the time, concrete structures need to be improved and strengthened. Polymeric sheets reinforced by fibers (FRP), according to their appropriate characteristic, are more efficient for strengthening concrete structures. Most studies on confined columns refers to confined RC columns with FRP and less mentioned about prestressed columns. In this study, the behavior of prestressed columns is analyzed by modeling a case of prestressed column in a nonlinear analysis software. Samples of confined concrete columns with CFRP and... 

For application as a biosensor electrode, Aligned Carbon Nanotubes (CNTs) were produced on Stainless Steel 304 substrate by optimizing the CVD method. For better performance, Zinc Oxide (ZnO) nanoparticles were coated on CNTs, using electrochemical deposition method at room temperature and process variables were optimized to acquire discrete particles with a narrow distribution. After that, Polyaniline, which is a conductive polymer, was electropolymerized on CNT/ZnO composite to further improve the electrocatalytic abilities of the electrode. The produced electrode was then used to detect glucose by Cyclic Voltammetry and Amperometry methods. This electrode shows a linear relationship... 

This thesis cantain two section. In the first section a novel extracting medium based on magnetic molecularly imprinted polymers (MIPs) nanoparticles was synthesized by chemical polymerization for micro-solid phase extraction. In this work, the modified chitosan magnetite nanoparticles (MNP-CS) was synthesized by co-precipitating Fe2+ and Fe3+ in the chitosan solution [1,2]. The characteristic properties of Fe3O4@MIPs nanoparticles were determined using Fourier transform infrared spectrometer. Extraction efficiency of the novel extracting medium was compared with MNP-CS sorbents for the determination of RhB in aqueous samples, via quantification by spectrofluorimetry. The obtained results... 

Most of the investigations during the two past decades focused on the effect of moisture and temperature on the bond at the interface of carbon or glass-fabrics and concrete, masonry or timber. Few investigations have studied the effect of chemical solutions, dry heat exposure and ultravilolent (UV) radiation on the bond at the interface of other types of fiber reinforced-polymers (FRPs) and masonry, timber and concrete in the short and long terms. Therefore, this research aims to investigate the effect of five chemical solutions with pH of 2.5±0.1, 7±0.1, 7.25±0.1, 10±0.1 and 12.5±0.1 on the interfacial bond strength between seven types of FRPs (unidirectional, bidirectional and hybrids)... 

Masonry buildings are wide spread in Iran and some other countries . These buildings are highly vulnerable to seismic excitations if not constructed in accordance with engineering fundamentals . Thus it is necessary to retrofit these structures to flee from humanitarian and economical damages inflicted by earthquakes. One of the critical vulnerabilities of masonry buildings is due to transverse instability of it’s infills . Therefore to study out of plane behavior of these elements , an infilled frame is modeled and analyzed with ABAQUS , the results of which is in good congruence with the experimental one . In this model , stress distribution due to one way arching action in the confined... 

In this study, epoxy resin has been modified by nano-clay additives using direct mixing method and epoxy-clay nanocomposites were designed and produced with optimized percentage of clay content. By adding the powder of born carbide and lead oxide in nanocomposites new compounds are obtained. The results are used for protection against neutron and gamma rays, respectively. After preparation of epoxy-clay-born carbide and epoxy- clay-lead oxide nanocomposite the effects of irradiation and carbon fiber on mechanical and thermal properties of nanocomposites were examined. The Nanocomposites were exposed to Electron Beam Irradiation (EBI) in 100 and 500 kGy doses to investigate the effect of... 

During times, reinforced concrete sturctures might need to be strengthened due to environmental factors, material properties, design errors or changes indesign guidelines.Fibre-reinforced-polymer (FRP)composites are prominentmaterialsfor this purpose. Externally full bonding systemhas been widely used for flexural strengthening of reinforced concrete sturctures with FRP. However, the drawback of using this strengthening system is the high reduction of structure's deformability.In this research, partially bonding system used in finite element modeling of a bridge’s deck to increase deformability compared to full bonding system. Results showed that not only deformability but also load... 

Today, the pollution of heavy metals in wastewater and surface waters, which is a global environmental problem, has increased with the expansion of various industrial activities. Heavy metals cause serious health problems due to their accumulation in human and animal tissues. Thorium, is a radioactive element with an atomic number of 90 that is widely used in the optics, aerospace, metallurgy and chemical industries, in the manufacture of high-strength alloys, in UV photocells, and especially in the nuclear industry. The primary sources of radioactive wastewater include nuclear power plants, nuclear energy industry research centers, medical institutions, industrial production, universities,... 

Porous polymeric particles have the extensive application in various sciences and various methods have been introduced for production of these particles. Depending on method of production, porous polymeric beads can be produced in diverse shapes, pore size, pores interconectivity, surface morphology and chemical properties. In common methods for production of porous polymeric particles, tuning the size and porosity is difficult or even impossible. Porous polymeric beads with the vast surface area and good functionality have been applied for adsorption of various materials. The purpose of this study is therefore to investigate a new procedure for the production of porous polymeric... 

Smart heat-sensitive polymers play a unique role in drug delivery systems due to reversible behavior in response to environmental changes, especially temperature changes. Among the heat-sensitive polymers, UCST polymers due to their specific behavior and very little-known polymers with this feature are the subject of many new researches. In the present study, New designed temperature-sensitive polymers with UCST capability based on acrylamide and vinyl acetate were synthesized. These copolymers were synthesized in different percentages of acrylamide by free radical polymerization in solution conditions. All polymers compounds were characterized by H-NMR, FT-IR, DSC and GPC measurements. The... 

Drilling fluid is one the most important part of drilling operations in the oil and gas wells digging. From an economic point of view, almost 25 to 45% of drilling costs are allocated to drilling fluid. Drilling fluids consist of several components with different physical and structural forms which can be assumed as complex fluids. Optimum performance of the drilling process could be obtained through the dynamic fluid computation which requires a reliable mathematical model capable to predict transient-state and steady-state rheological behavior of drilling fluid. Generalized Newtonian models, such as the Bingham-plastic model, the power model, and the Herschel-Bulkley model, are the most... 

In recent years, liquid resin injection processes for aviation applications have been considered an alternative to conventional autoclave-based processes. At present, these processes have challenges that have been denied industry trust due to their inability to be objectively reproducible. In the last decade, some software has been developed to simulate the vacuum injection process, but this software does not have enough capability to predict the injection network, and an operator with sufficient empirical knowledge must use this software. In recent years, researchers have used this softwares to simulate the process, but so far no software has been developed that can offer injection... 

It is about half century passed from the invention and application of the polymer flooding. Although there are successful reports from the using polymer flooding, but there are problems that in some cases this process fails. For more insight on the problems and in order to improve
the efficiency of this process the conceptual understanding of the process is required. More conceptual understanding from this process, requires investigation in pore scale. In the presenting investigation, the flow of Newtonian and non-Newtonian fluids in the single phase and two phase form and in pore scale are simulated using finite volume method. Because, the finite volume method is used in very... 

The new generation of electronic devices including 5G internet, wearable electronics, LED optoelectronics or cloud computing devices have higher power density as their computing power increases and their sizes reduce. The increase in power density leads to higher heat generation and consequently higher operating temperature which reduces their lifetime and reliability. In recent years development of novel solutions for electronic cooling has been persued. Thermal interface material that inserted between heat source and heat sink is the main component in electronic cooling. These materials consists of a polymeric base that filled with highly thermally conductive solid particles. By emergence... 

A total of twenty-four reinforced concrete arches with dimensions of 110 × 30 × 10 cm were casted, fabricated and tested. There are three variables, including: height to span ratio, longitudinal reinforcement ratio and arrangement and number of FRP layers.Based on results, with increasing height to span ratio, the efficiency of FRP strengthening method decreases. It is due to the fact that FRP materials inherently behave better in tension. From another point of view, in lower arches (L group) extrados bonding technic has better effect on increasing peak load of the arches, while in higher ones (H group) intrados bonding is discerned as the best method of strengthening. This paradoxical... 

Tumor markers are substances that are naturally found in blood and other fluids in body, but in abnormal conditions such as cancer and metastasis, their level increase. The aim of researching about tumor markers is to find a way for discovering cancer only with a blood test and replace with the current methods such as ELISA, and any type of cancer can be detected by these tests. In this study, molecular imprinted polymers were synthesized with biomolecules. To do that, silica microparticles were used as solid base and after functionalizing their surface, a thin film of polymer was synthesized on them. To optimize the components concentrations and the polymer thickness on the silica surface,... 

Buried pipes are among the most important urban infra-structures which are developed to distribute water, gas, oil, etc.. Researchers have already demonstrated that extreme failures which lead to total disruption of the pipelines, both mains and the distribution network, due to permanent ground displacement in fault zones. In order to avoid any disturbance in the regular performance of pipelines and prevention of environmental contamination, there is a need to investigate the vulnerability of pipelines and their seismic retrofitting, if necessary. In the presented study, the method of pipeline retrofitting by high strength CFRP composite is investigated. In that regard, using a 3D model of... 

Nowadays, the development of different polymer blend nanocomposites is of great importance for achieving electrical and antistatic properties for various applications such as auto parts and the packaging industry. Immiscible polymer blends with conductive nanoparticles such as carbon nanotube, graphene, etc. can reach the conductivity threshold with low amounts of nanoparticles and produce desired electrical properties. In the present study, we have attempted to develop a polystyrene(PS)/ethylene-octene copolymer(EOC)/carbon nanotube(CNT) blend nanocomposite with suitable electrical conductivity. The compounding was performed by melt mixing at two weight percent of 80/20 and 50/50 (PS/EOC)...