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- Type of Document: Book
- Publisher: Singapore : Springer , [2018]
- Keywords:
- Enzymes -- chemistry ; Catalysis ; Kinetics
Digital Object List
محتواي کتاب
Bookmark- Preface
- Useful Constants and Conversion Factors
- Acknowledgments
- Contents
- About the Author
- Part I: Enzyme Catalysis - A Perspective
- 1: Enzymes: Their Place in Biology
- 2: Enzymes: Historical Aspects
- 3: Exploiting Enzymes: Technology and Applications
- 4: On Enzyme Nomenclature and Classification
- 5: Hallmarks of an Enzyme Catalyst
- 6: Origins of Enzyme Catalytic Power
- 7: Which Enzyme Uses What Tricks?
- 8: Structure and Catalysis: Conformational Flexibility and Protein Motion
- Part II: Enzyme Kinetic Practice and Measurements
- 9: Chemical Kinetics: Fundamentals
- 10: Concepts of Equilibrium and Steady State
- 11: ES Complex and Pre-steady-state Kinetics
- 12: Principles of Enzyme Assays
- 13: Good Kinetic Practices
- 14: Quantification of Catalysis and Measures of Enzyme Purity
- 15: Henri-Michaelis-Menten Equation
- 16: More Complex Rate Expressions
- 17: Enzyme Kinetic Data: Collection and Analysis
- Part III: Elucidation of Kinetic Mechanisms
- 18: Approaches to Kinetic Mechanism: An Overview
- 19: Analysis of Initial Velocity Patterns
- 20: Enzyme Inhibition Analyses
- 21: Irreversible Inhibitions
- 22: Reversible Inhibitions
- 23: Alternate Substrate (Product) Interactions
- 24: pH Studies with Enzymes
- 25: Isotopes in Enzymology
- 26: Isotope Exchanges at Equilibrium
- 27: Isotope Effects in Enzymology
- 28: From Kinetic Data to Mechanism and Back
- Part IV: Chemical Mechanisms and Catalysis
- 29: Chemical Reactivity and Molecular Interactions
- 30: Acid-Base Chemistry and Catalysis
- 31: Nucleophilic Catalysis and Covalent Reaction Intermediates
- 32: Phosphoryl Group Chemistry and Importance of ATP
- 33: Enzymatic Oxidation-Reduction Reactions
- 34: Carboxylations and Decarboxylations
- 35: Electrophilic Catalysis and Amino Acid Transformations
- 36: Integrating Kinetic and Chemical Mechanisms: A Synthesis
- 36.1 Competence of the Proposed Reaction Intermediate
- 36.2 Glutamine Synthetase
- 36.3 Glutamate Dehydrogenase
- 36.4 Disaccharide Phosphorylases
- 36.5 Acyl Transferases
- 36.6 Chymotrypsin
- 36.7 Aldolases and Transaldolase
- 36.8 Ribonuclease A
- 36.9 Interdependence of Kinetic and Chemical Mechanisms: A Summary
- References
- Part V: Frontiers in Enzymology
- 37: Regulation of Enzyme Activity
- 37.1 Control of Enzyme Concentration
- 37.2 Control of Enzyme Activity: Inhibition
- 37.3 Control of Enzyme Activity: Cooperativity and Allostery
- 37.4 Isozymes and Regulation
- 37.5 Covalent Modifications and Control
- 37.6 Protein-Protein Interactions and Enzyme Control
- 37.7 Compartmental Regulation and Membrane Transport
- 37.8 Glutamine Synthetase: An Anthology of Control Mechanisms
- 37.9 Summing Up
- References
- 38: In Vitro Versus In Vivo: Concepts and Consequences
- 39: Future of Enzymology: An Appraisal
- 40: Closure - Whither Enzymology
- 37: Regulation of Enzyme Activity
- Bibliography