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Source Localization of EEG in Early Alzheimer’s Disease

Salami, Mohsen | 2012

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 43242 (19)
  4. University: Sharif University of Technology
  5. Department: Computer Engineering
  6. Advisor(s): Manzuri Shalmani, Mohammad Taghi
  7. Abstract:
  8. Localization of electrical activity in the brain is one of the major problems in cognitive science and neuroscience. Indeed, Source localization is the inverse processing procedure on brain signals to estimate the location and position of resources in the human brain. Current technics for neurological imaging is included fMRI، PET، MEG and ERP. These methods is not appropriated to answer the question that when does each of different components of the brain begin their activity. The EEG signals could be useful to eliminate some of limitations of above methods. The problem with EEG signals collected from the skull is that they don’t refer directly to the location of active neurons. The approach for solving this problem is called the inverse problem. This problem computes the parameters of a model by the use of its output results. Many approaches are used to solve the inverse problem which are dofferent in mathematics, biophysical conditions, static and anatomical conditions.
    In this Thesis, we have used the sLORETA method for the purpose of localization of electrical activities in the brain. A reason to do this is the small localization error of this method with respect to other methods. We have applied this method to EEG data of two group including controls and patients which are at early stages of Alzheimer’s disease. Then we have compared the results by the use of statistical methods. Furthermore we have shown that the slowing EEG phenomenon occurs in patient’s data
  9. Keywords:
  10. Inverse Problem ; Alzheimer ; Standardized Low Resolution Brain Electromagnetic Tomography (SLORETA) ; Brain Waves ; Electroencephalography ; Brain Source Localization

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