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standardized-low-resolution-brain-electromagnetic-tomography--sloreta
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Alzheimer's Disease Diagnosis Using Brain Source Localiztion, Based on Realistic Head Model
, M.Sc. Thesis Sharif University of Technology ; Vosoughi Vahdat, Bijan (Supervisor) ; Jalili, Mahdi (Co-Advisor)
Abstract
Dementia is one of the most common disorders among the elderly population. Statistical analyses show that among several subtypes of dementia, Alzheimer’s disease (AD) is the most frequent cause of dementia and this number is projected to increase. AD not only results in impairment of learning and memory but also in the moderate stages of illness, motor functions are profoundly disturbed, and ultimately will affect the patient's lifetime. The proposed drug treatments for this disease only reduce its progress probability. Therefore, early diagnosis for effective treatment of Alzheimer's disease is one of the critical issues in the field of dementia. This project is an effort to extract...
Source Localization of EEG in Early Alzheimer’s Disease
, M.Sc. Thesis Sharif University of Technology ; Manzuri Shalmani, Mohammad Taghi (Supervisor)
Abstract
Localization of electrical activity in the brain is one of the major problems in cognitive science and neuroscience. Indeed, Source localization is the inverse processing procedure on brain signals to estimate the location and position of resources in the human brain. Current technics for neurological imaging is included fMRI، PET، MEG and ERP. These methods is not appropriated to answer the question that when does each of different components of the brain begin their activity. The EEG signals could be useful to eliminate some of limitations of above methods. The problem with EEG signals collected from the skull is that they don’t refer directly to the location of active neurons. The...
Diagnosis of early Alzheimer's disease based on EEG source localization and a standardized realistic head model
, Article IEEE Journal of Biomedical and Health Informatics ; Volume 17, Issue 6 , 2013 , Pages 1039-1045 ; 21682194 (ISSN) ; Zahedi, E ; Jalili, M ; Keikhosravi, A ; Vahdat, B. V ; Sharif University of Technology
2013
Abstract
In this paper, distributed electroencephalographic (EEG) sources in the brain have been mapped with the objective of early diagnosis of Alzheimer's disease (AD). To this end, records from a montage of a high-density EEG from 17 early AD patients and 17 matched healthy control subjects were considered. Subjects were in eyes-closed, resting-state condition. Cortical EEG sources were modeled by the standardized low-resolution brain electromagnetic tomography (sLORETA) method. Relative logarithmic power spectral density values were obtained in the four conventional frequency bands (alpha, beta, delta, and theta) and 12 cortical regions. Results show that in the left brain hemisphere, the theta...