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Magnetic and light-responsive nanogels based on chitosan functionalized with Au nanoparticles and poly(: N-isopropylacrylamide) as a remotely triggered drug carrier

Pourjavadi, A ; Sharif University of Technology | 2020

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  1. Type of Document: Article
  2. DOI: 10.1039/d0nj02345k
  3. Publisher: Royal Society of Chemistry , 2020
  4. Abstract:
  5. In the past few years, laser-assisted methods have greatly influenced biomedical studies due to less invasive ways of treatment and higher precision. New stimuli-responsive drug carriers are still explored by scientists to achieve a better spatiotemporal control of drug carriers by using visible to NIR light instead of phototoxic ultra-violet irradiation. Due to their biocompatibility and high loading capacity of hydrophilic drugs, hydrogels have been used extensively in this area. However, poor cellular uptake and restricted loading of hydrophobic drugs are challenges that should be addressed. In this study, a previously known nanogel system based on chitosan and poly(N-isopropylacrylamide) was synthesized and optimized to reach a light-responsive drug carrier. Gold nanoparticles (GNPs) were formed in situ on the surface of chitosan to act as photothermal transducers. The chemical structure optimization led to spherical and uniform nanogels with high photothermal conversion ability. The effects of the loading of Fe3O4 nanoparticles on the drug release profiles were also examined. This comprehensive study revealed the considerable potential of the achieved intelligent nanogel as a visible light-sensitive drug carrier. This journal is © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique
  6. Keywords:
  7. Acrylic monomers ; Amides ; Biocompatibility ; Chitosan ; Gold nanoparticles ; Iron oxides ; Light ; Magnetite ; Nanomagnetics ; Nanoparticles ; Nanostructured materials ; Structural optimization ; Fe3O4 nanoparticles ; Gold nanoparticles (GNPs) ; N- isopropylacrylamide ; Photo-thermal conversions ; Poly (n isopropylacrylamide) ; Spatiotemporal control ; Structure optimization ; Ultraviolet irradiations ; Controlled drug delivery
  8. Source: New Journal of Chemistry ; Volume 44, Issue 40 , 2020 , Pages 17302-17312
  9. URL: https://pubs.rsc.org/en/content/articlelanding/2020/nj/d0nj02345k#!divAbstract