Sharif Digital Repository

In the present thesis, intracellular fluid flows have investigated for study cell motions. It is due to firmly relation between the cell motion and these flows. Generally, the cell firstly adheres to a surface, then, moves forward with the effects of the internal fluid flows. In this study, the cell structure is invided to two general parts; the front part of the cell and the cell body. The front part of the cell plays a essential roles in the cell motion, however, the cell body is considered as a extra cargo that is carried by the front of the cell. Therefor, in the present modellings, the front part is only considered. Here, using four different models for the front part of the cell, many... 

Transdermal drug delivery systems are products which are known to have ability to pass drugs through the skin and into the blood, so medicine effects appear as a result. During the past two decades, many scientists interested in drug delivery through the skin. Constant blood plasma level and avoiding first-pass metabolism are advantages of this system compared to oral and intravenous systems. The biggest problem in the development of these systems, is impermeability of Stratum corneum, the outermost layer of the epidermis. In this study, design and evaluation of in vitro transdermal drug delivery system for granisetron serve as treatment of nausea and vomiting was performed. For this... 

Viability and proliferation of cells in cell culture mainly depends on i) cell culture medium, ii) cell-cell interaction, and iii) the supporting scaffold. Among these factors, and within recent years, surface and mechanical properties of the supporting ECM has attracted many researchers. Experiment results show that the animal cell adhesion is accelerated on stiffer scaffolds. Electrical charge of the scaffold is also a determinant term in the kinetics of adhesion and on a relatively charged scaffold, one can expect an increment in kinetics of adhesion front movement. This is due to the natural negative charges of the cell wall membrane. In this thesis, an analytical model is proposed to... 

A series of poly(ethylene-co-vinyl acetate) (EVA)-based hot melt adhesives containing either a raw rosin or a hydrogenated rosin ester have been prepared to investigate variation of viscosity, softening point and peel adhesion with composition. Adhesion of the prepared hot melt adhesive to the substrate was characterized by T-peel strength test. Increasing rosin had a prominent effect on the adhesion. Viscosity decreased and softening point increased as the wax content increased. Addition of zinc borate as a flame retardant decreased T-peel energy and increased the viscosity and softening point of the samples. Higher peeling strength accompanied with a good softening point and viscosity... 

The purpose of this study was to create a three-cationic electro phosphate coating of zinc-nickel-manganese by cathodic method and to investigate the effect of operating variables on the properties of zinc-nickel-manganese tri-cationic electro phosphate coating. Hence, the effects of variables such as coating acidity, coating thickness, coating temperature, coating time and concentration of manganese were studied in the bath on the properties such as coating morphology, corrosion resistance, coating thickness. Coating morphology was characterized by scanning electron microscopy and corrosion resistance by polarization test. The pH values of 1.4, 1.8, 2 and 2.2 were selected, and the results... 

Today, computer simulations are employed prevalently by researchers to understand biological processes. The tendency to use computational methods has been increased recently due to the high costs and errors of experimental methods. Integrins are membrane proteins that mechanically attach cells to the extra cellular matrix (ECM) and derive some behaviors such as cell migration. Moreover, integrins have biochemical functions. They transduce environment signals and trigger chemical pathways. As a result, integrins regulate cell shape, motility, etc. The investigation of integrin behavior in a real environment is very difficult due to the presence of many other proteins that interfere with the... 

The network of actin filaments is one of the three elements of the Cytoskeleton and plays a role in cell shape and migration. The actin network is dynamic; it (de)polymerizes, and in migrating and spreading cells, it is in a retrograde motion from the cell periphery toward cell nucleus. Adhesion points, which link the cytoskeleton to the extracellular matrix, interact with the actin retrograde flow. Actin filaments can be identified in two distinct regions in which their structure, flow velocity, driving force and size of the adhesions are different; the outer region is called Lamellipodium and the inner one Lamellum. In macro scale and regarding spreading cells, considering adhesions... 

One of the most important factors affecting the performance of the vehicle's brake disc is its stiffening coefficient. To improve this feature, many researches have been carried out by leading automotive companies, whose scientific aspects have not yet been widely disseminated. Brake discs are often made of cast iron and are more likely to produce gray iron with type A graphite. However, according to available resources, factors such as graphite morphology, their length-to-thickness ratios, cast iron and heat treatment on the piece affect this important feature. One of the most important factors that make changes in the above mentioned cases is the chemical composition and freezing rate. In... 

We propose a model for friction between two rough surfaces based on extreme value statistics (EVS). Different models for single-asperity contact, including adhesive and elasto-plastic contacts, were combined with EVS. The Hertzian model for contacts and Gumbel distribution for summit heights show the closest conformity with Amonton’s law. The range over which Gumbel distribution mimics Amonton’s law is wider than that of the Greenwood–Williamson (GW) model. In comparison with other EVS distribution, Gumbel distribution seems the proper choice for summit‘ s height. Interestingly, here again, elasto-plastic contact and Gumbel distribution for summits achieve the best conformity with Amontons... 

Membrane Technology is rapidly growing all over the world because of many applications. In all of this applications , use of adhesive ( between membranes and wall ) is necessary. selection of appropriate adhesive for membrane is very important in order to membrane has best performance and lifetime .Adhesives used in membrane technology must have good adhesion and suitable hardness . One of the newest adhesives used in membrane technology is two-component polyurethane adhesive. PU adhesives make strong and durable bond and have good flexibility which is an advantage for membrane technology.MDI isocyanate is used in most of commercial PU adhesives’ formulation. But in this study , modified MDI... 

Endothelium is the interior layer of an artery made up of tremendous number of endothelial cells which are located side by side. Finding the effective parameters that cause the cells to obtain mechanical strength in different morphologies is a major effort in cell engineering studies. In this work a numerical model for endothelial cells is developed. This model has included cell's plasma membrane (the outer membrane of the cell), nucleus and cytoskeleton main components including intermediate and actin filaments as well as microtubules. The model has been validated by simulating the adhesion of the cells to a flat substrate and also atomic force microscopy (AFM) experiments. The two most... 

Obstruction of Left Anterior Descending artery (LAD) due to thrombosis or atherosclerotic plaques is the leading cause of death world–wide. Targeted delivery of drugs through micro- Nano-particles holds noteworthy promise which can make clot busting or the restenosis treatment with minimal toxicity possible. In this work, Fluid-Structure Interaction (FSI) simulations of blood flow through a patient-specific reconstructed geometry of LAD artery have been conducted using a non-Newtonian hematocrit (HCT) dependent model for blood. Based on physiological facts, 25, 45 and 65 percentages of HCT were assumed as acceptable representations of anemic, healthy and diabetic blood conditions,... 

A finite element model for seismic analysis of concrete arch dams is proposed. Material inelasticity as well as joints nonlinearity is considered. In order to provide a precise description of concrete response, a novel plastic-damage constitutive model for plain concrete is developed. For this purpose, the microplane theory is proposed for overcoming the deficiency of available anisotropic continuum plastic-damage models in reproducing the true anisotropic nature of damage in multidimensional loadings.Based on the microplane theory, the degeneration process in concrete is considered along with plastic deformations. Using the principle of strain energy equivalence, a transformation between... 

Nowadays, metal-polymer dissimilar joints have attracted the attention of many industries, and the aplication of these joints in various industries such as automotive and aerospace is increasing. However, due to considerable differences in physical properties of metals and polymers, proper bonding between these materials is not easily possible, and metal-polymer joining remains one of the major challenges in the development of advanced composite structures. The adhesive/friction stir joining hybrid process is a relatively new idea that has been proposed to achieve longer lasting bonds and more safe structures. Using this process for metal-polymer joining can take advantage of both methods;... 

316L stainless steel is used in implants under load in orthopedics and dentistry due to its high strength and corrosion resistance. Therefore, to improve their biocompatibility properties, bioceramic coatings with more suitable biocompatibility properties are used. Therefore, in the present study, to improve the biocompatibility and corrosion properties on 316 L metal implants, HAp / TiO2 / Al2O3 nanocomposite coating was created using the cost-effective sol-gel method. Titanium + alumina by weight percentage in these coatings were 20, 30, and 40% by weight. In this study, FTIR, XRD, DSC / TG, FE-SEM EDS, DLS tests were performed to investigate the chemical bases in nanocomposites,... 

Today, the cleaning and moss removal of the hulls of ships is very important due to the strict and international laws of reducing pollutants and the exorbitant cost of fuel of the country's navy. The advantages of cleaning the hull of vessels are reduced fuel consumption, increased ship speed and longer hull life. Traditionally, the hulls are cleaned by divers, and in recent years the use of crawling robots has been welcomed by the industry because of its benefits. This important thing in Iran is still done by divers and therefore the need for indigenous development of such robots in the country is felt.In the present study, the aim is to design and build a reliance system for the ship's... 

Nowadays adhesives with the development of technology and the numerous benefits they have, are becoming a replacement for traditional joining methods in industries like electronics, automotive, aerospace, and naval. That’s why the need for studying the fracture behavior of adhesive joints becomes vital. So far, many engineers and designers are trying to investigate the behavior of adhesive joints in different conditions that these joints actually deal with. Also, finding solutions to predict the behavior of adhesive joints is the researchers’ other concern. The purpose of this research is to find the effect of factors that are less focused in the literature, on the fracture of adhesive... 

Creating sustainable development in today's human societies is essential, one of the pillars of achieving this important goal is environmental protection. Thus, waste management as a new challenge is leading engineers. Lead-acid battery waste is one of the sources of environmental pollution. Lead-acid battery separators contain 50% recyclable nanosilica. The main challenge of recycling nanosilica from separators is the presence of significant amounts of 6 to 9% wt.% of lead and 5% by weight of other impurities. Therefore, in the present study, lead trapped in the separating pores is removed using mechanical washing or abrasive washing. Then, the quality of recycled nanosilica is evaluated... 

Today because of increasing use of fuel, environmental problems and problems due to heavy structures in different industries it is important to use structures with high specific strength. Using different materials in structures like polymers accompanying aluminum could be useful. Polymers are light, heat insulating and have a high corrosion resistance. Polypropylene is one of the useful polymers which can have high impact energy and strength via adding Elastomer and Talc powder, relatively. One of the common ways in joining metal to polymer uses adhesive. It has variety of benefits such as low distortion in joining, different materials joints and having joints with complex geometry. Welding... 

Ice formation upon various surfaces could lead to many industry problems and result in unpleasant accidents. For instance, the formation of ice on wind turbine blades or airplanes/helicopter wings could cause catastrophic disasters. The methods used to address this problem usually require exogenous energy consumption or anti-ice ingredients. The energy or anti-ice ingredients usage has adverse environmental effects and should be replaced with better approaches. One of these approaches is utilizing modified anti-ice surfaces. In this method, by modifying surface features, such as physical asperities and surface energy, the icing time of the surface could be prolonged. These surfaces are...