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Solvent-free synthesis of 2-amino-3-aryl-5-substituted thiophenes as anti-inflammatory agents using KF-Al2O3 under microwave irradiation

Saeidian, H ; Sharif University of Technology | 2008

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Type of Document: Article
DOI: 10.1080/00397910801997843
Publisher: 2008
Abstract:
The synthesis of 2-amino-3-aryl-5-substituted thiophenes as anti-inflammatory agents catalyzed by KF-Al2O3 under microwave irradiation is reported. Copyright © Taylor & Francis Group, LLC
Keywords:
(4 bromo phenyl) (5 morpholin 4 yl 4 phenyl thiopene 2 yl) methanone ; 4 (1 benzylsulfanyl 2 phenyl buta 1,3 dienyl) morpholine ; 4 biphenyl 4 yl 5 morpholin 4 yl thiopene 2 carboxylic acid ethyl ester ; 5 morpholin 4 yl 4 phenyl thiopene 2 carboxylic acid (4 chloro phenyl)amide ; 5 morpholin 4 yl 4 phenyl thiopene 2 carboxylic acid 3 tolylamide ; 5 morpholin 4 yl 4 phenyl thiopene 2 carboxylic acid naphthalene 1 ylamide ; Antiinflammatory agent ; Thiopene derivative ; Catalyst ; Chemical reaction ; Drug structure ; Drug synthesis ; Microwave cooking ; Microwave irradiation ; Proton nuclear magnetic resonance
Source: Synthetic Communications ; Volume 38, Issue 12 , 2008 , Pages 2043-2053 ; 00397911 (ISSN)
URL: https://www.tandfonline.com/doi/abs/10.1080/00397910801997843?journalCode=lsyc20