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Simulation of Cell and Particle Separation by Combination of Dielectrophoretic and Inertial Forces in a Microfluidic Device

Sorour Amini, Hossein | 2020

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 53091 (06)
  4. University: Sharif University of Technology
  5. Department: Chemical and Petroleum Engineering
  6. Advisor(s): Mohammadi, Ali Asghar
  7. Abstract:
  8. In this study, the dynamics of microparticles in a straight microchannel in the presence of an inhomogeneous oscillating electric field have been simulated by the immersed boundary method in combination with the lattice Boltzmann Navier-Stokes solver and the lattice Boltzmann method for solving the Poisson equation. The effect of the electric field on the location and number of particle equilibrium positions have been examined. In the absence of the electric field, circular particles will migrate to two stable equilibrium positions. The site of these equilibrium positions depends on the particle size and the fluid flow rate and is independent of the particle density. In the case of negative dielectrophoresis, for each particle, there exists a specific voltage so-called crossover voltage at which the equilibrium position near electrodes disappear, and particles migrate to the other equilibrium position far from the electrodes. The electric field does not influence this equilibrium position. Finally, a novel two-step DEP-assisted inertial microfluidics mechanism has been introduced for particle separation. The proposed hybrid method has been utilized to separate different sized polystyrene beads
  9. Keywords:
  10. Lattice Boltzmann Method ; Immersed Boundary Method (IBM) ; Dielectrophoresis Technique ; Inertial Microfluidic Device ; Microfluidic System ; Particles Separation

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