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Graphene oxide strongly inhibits amyloid beta fibrillation

Mahmoudi, M ; Sharif University of Technology | 2012

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  1. Type of Document: Article
  2. DOI: 10.1039/c2nr31657a
  3. Publisher: 2012
  4. Abstract:
  5. Since amyloid beta fibrillation (AβF) plays an important role in the development of neurodegenerative diseases, we investigated the effect of graphene oxide (GO) and their protein-coated surfaces on the kinetics of Aβ fibrillation in the aqueous solution. We showed that GO and their protein-covered surfaces delay the AβF process via adsorption of amyloid monomers. Also, the large available surface of GO sheets can delay the AβF process by adsorption of amyloid monomers. The inhibitory effect of the GO sheet was increased when we increase the concentration from 10% (in vitro; stimulated media) to 100% (in vivo; stimulated media). Conclusion: our results revealed that GO and their surface proteins inhibit AβF by decreasing the kinetic reaction
  6. Keywords:
  7. Amyloid betas ; Graphene oxides ; In-vitro ; In-vivo ; Inhibitory effect ; Kinetic reactions ; Surface proteins ; Glycoproteins ; Monomers ; Proteins ; Amyloid beta protein ; Oxide ; Atomic force microscopy ; Chemistry ; Metabolism ; Adsorption ; Amyloid beta-Peptides ; Graphite ; Kinetics ; Microscopy, Atomic Force ; Oxides ; Water
  8. Source: Nanoscale ; Volume 4, Issue 23 , 2012 , Pages 7322-7325 ; 20403364 (ISSN)
  9. URL: http://pubs.rsc.org/en/Content/ArticleLanding/2012/NR/c2nr31657a#!divAbstract