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Investigation of Modeling Arterial Tissue Growth and Remodeling Under Biaxial Loading Conditions

Badiee, Mohammad Mehdi | 2021

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 54540 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Asghari, Mohsen
  7. Abstract:
  8. Cardiovascular diseases are one of the leading causes of death in the world. Identifying the mechanical behavior of arteries and their growth and remodeling under applied loadings can help to better understand the progression of the disease and provide more effective clinical interventions. Therefore, many researchers in recent decades have turned their attention to modeling the process of stress-mediated growth and remodeling in soft tissues. Among the most important models proposed to study this process are the constrained mixture model proposed by Humphrey et al. and the volumetric growth model proposed by Hoger et al.. The constrained mixture model is based on the continuous turnover of constituents and the evolution of their natural configurations according to the mechanisms that guide growth and remodeling, which makes the model very computationally heavy and costly. In contrast, the volumetric growth model focuses on the consequences of growth and is mathematically simpler. Despite its simplicity, the volumetric growth model has great potential in predicting and investigating the geometry and residual stresses caused by growth in soft tissues, and this needs to be further researched and studied. The purpose of this study is to investigate the constrained mixture model and the volumetric growth model and to measure the potential of the volumetric growth model by examining it under uniaxial and biaxial loadings
  9. Keywords:
  10. Growth ; Remodeling ; Soft Tissues ; Stress Mediated Growth ; Volumetric Growth ; Constrained Mixture ; Heart Diseases

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