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Atorvastatin treatment softens human red blood cells: an optical tweezers study

Sheikh Hasani, V ; Sharif University of Technology | 2018

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  1. Type of Document: Article
  2. DOI: 10.1364/BOE.9.001256
  3. Publisher: OSA - The Optical Society , 2018
  4. Abstract:
  5. Optical tweezers are proven indispensable single-cell micro-manipulation and mechanical phenotyping tools. In this study, we have used optical tweezers for measuring the viscoelastic properties of human red blood cells (RBCs). Comparison of the viscoelastic features of the healthy fresh and atorvastatin treated cells revealed that the drug softens the cells. Using a simple modeling approach, we proposed a molecular model that explains the drug-induced softening of the RBC membrane. Our results suggest that direct interactions between the drug and cytoskeletal components underlie the drug-induced softening of the cells. © 2018 Optical Society of America
  6. Keywords:
  7. Blood ; Cells ; Cytology ; Micromanipulators ; Molecular biology ; Viscoelasticity ; Atorvastatin ; Cytoskeletal components ; Direct interactions ; Human red blood cell ; Micro manipulation ; Simple modeling ; Single cells ; Viscoelastic properties ; Optical tweezers ; Ankyrin ; Factin ; Spectrin ; Antiinflammatory activity ; Erythrocyte ; Erythrocyte membrane ; Human ; Human cell ; Mathematical phenomena ; Molecular docking ; Molecular dynamics ; Phenotype ; Protein conformation ; Protein interaction ; Relaxation time
  8. Source: Biomedical Optics Express ; Volume 9, Issue 3 , 2018 ; 21567085 (ISSN)
  9. URL: https://www.osapublishing.org/boe/abstract.cfm?uri=boe-9-3-1256