Sharif Digital Repository

The parasite entering into the blood of a malaria infected individual eventually causes the formation of gametocytes inside the blood cells. With the insect bite, the male and female gametes will enter the insect's stomach and form the zygote. After developing in the stomach, the zygote first turns into an ookinete and then into an oocyst, and by passing through the stomach wall and tearing the sporozoites, it enters the salivary glands of the insect, and if another person is bitten by that insect, the parasite enters the body of that person. and this cycle continues between the insect and the human body. Stopping this cycle requires blocking one part of this cycle. Studies show that... 

The image-based profile is a technology by which image morphology information is transformed into a multidimensional profile from a set of image-derived features. These profiles can be used to extract biologically meaningful biological information. For example, in the drug discovery process, the mechanism of action of a drug or disease can be identified by examining the morphological properties of the drug in the patient’s cell or tissue and used to design new drugs or use existing drugs for various diseases. High-throughput imaging technology allows the imaging of a large number of different experiments. Extracting valuable features and a good representation of features is the main... 

Metal-organic frameworks (MOFs) are a new class of biocompatible nanomaterials with high specific surface area, which provide the possibility of loading various therapeutic agents. Considering the few studies on the use of MOFs in melanoma cancer treatment, the main goal of this research is to investigate the loading and controlling the release of dacarbazine (DTIC) and also the interaction of DTIC and MOF structure in aqueous environments. Based on this, this study was done in three main parts. In the first part, several types of well-known and often used structures in the drug delivery field, including ZIF-8 (based on zinc), MIL-101-NH2(Fe), and MIL-100(Fe) (both based on iron), were... 

Cyclin-dependent kinases 2 (CDK2) are one of the important proteins in cell cycle regulation and progression. In many human cancer cells, the activity of CDK2 kinases and their related subunits are deregulated, leading to tumor formation. Therefore, inhibition of this enzyme as an attractive therapeutic target can cause cancer cell death in glioblastoma and diffuse large B-cell lymphoma. Using new pharmaceutical structures based on sugar and amino acids is a new approach due to its greater efficacy and fewer side effects than old drugs. In this research, according to the structure of Flavopiridol as one of the CDK2 inhibitors, the active site of CDK2, and the structure of ATP molecule, 50... 

Enzymes are proteins that carry out chemical reactions in the form of chemo, stereo, and regioselective under mild conditions. One of the characteristics of enzymes is that they perform a specific chemical reaction on a selective substrate and under specific environmental conditions. However, in recent years, a number of enzymes have been identified to display promiscous behavior. This promiscousity includes catalytic activity, variety of substrates, and environmental conditions. Promiscous activities of enzymes can be a good starting point for creating new and more favorable engineered pathways for the production of chemical and medicinal drugs. One of the aims of this project is to exploit...