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Two-phase acto-cytosolic fluid flow in a moving keratocyte: a 2d continuum model

Nikmaneshi, M. R ; Sharif University of Technology | 2015

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  1. Type of Document: Article
  2. DOI: 10.1007/s11538-015-0105-5
  3. Publisher: Springer New York LLC , 2015
  4. Abstract:
  5. The F-actin network and cytosol in the lamellipodia of crawling cells flow in a centripetal pattern and spout-like form, respectively. We have numerically studied this two-phase flow in the realistic geometry of a moving keratocyte. Cytosol has been treated as a low viscosity Newtonian fluid flowing through the high viscosity porous medium of F-actin network. Other involved phenomena including myosin activity, adhesion friction, and interphase interaction are also discussed to provide an overall view of this problem. Adopting a two-phase coupled model by myosin concentration, we have found new accurate perspectives of acto-cytosolic flow and pressure fields, myosin distribution, as well as the distribution of effective forces across the lamellipodia of a keratocyte with stationary shape. The order of magnitude method is also used to determine the contribution of forces in the internal dynamics of lamellipodia
  6. Keywords:
  7. Contractile stress ; Cytosolic flow ; F-actin flow ; Focal adhesion ; Myosin motor protein ; Volume fraction
  8. Source: Bulletin of Mathematical Biology ; Volume 77, Issue 9 , September , 2015 , Pages 1813-1832 ; 00928240 (ISSN)
  9. URL: http://link.springer.com/article/10.1007%2Fs11538-015-0105-5