Sharif Digital Repository

A hybrid model based on the flow function and dislocation cell structure model by considering the Taylor assumption is utilized to model the dislocation structure evolution, cell size and mechanical properties of OFHC in severe plastic deformation. Here, the ECAP is chosen as a process of severe plastic deformation. In this study, the model is modified by taking the value of cell size coefficient as a function of strain and considering two different values of dynamic recovery coefficients of cell walls and cell interiors. These modifications lead to achieve the more accurate modeling results. From the flow function the strain rate distribution are achieved and then using the model the... 

Electroporation is permeabilization of the cell membrane, caused by an external electric field. Because of minimal thermal effects and minimal disturbance caused to tissue vasculature electroporation is becoming one of the methods of choice in tumor therapy. There has been no report indicating that reversible electroporation can be detected by ultrasound. In this work a cellular model for monitoring the electroporation process b; ultrasound RF signals is proposed. The density of aqueous pores with different sizes was found by applying the asymptotic model of electroporation and Smoluchowski equation. The cellular model was send to an ultrasound simulation program where pores were modeled by... 

SRAM cell stability assessment is traditionally based on static criteria of data stability requiring three coincident points in DC butterfly curves. This definition is based on static (DC) characteristics of the cell transistors. We introduce the dynamic criteria of cell data stability knowing that the cell operates in a dynamic environment alternating between access and non-access conditions. The proposed definition of the dynamic data stability criteria introduces a new bound for the cell static noise margin (SNM). It reveals that the true noise margin of the cell can be made considerably higher than the conventional SNM once the cell access time is sufficiently shorter than the cell... 

Acute lymphoblastic leukemia is one of the most common hematologic malignancies among children, caused by uncontrolled growth of leukocytes. Since the main hallmarks of the disease is not specific, a considerable number of patients have been being misdiagnosed. Early diagnosis of the disease is usually made by morphological investigation of leukocytes under microscope. In light of the facts that decrease in cytoplasm-to-nucleus ratio is one of the main indicators of cancerous cells, and an accurate segmentation phase will lead to extraction of representative features, segmentation step is acknowledged as being crucial in design of a computer aided diagnosis (CAD). Previous researches have... 

Skeletal muscle tissue engineering aims to fabricate tissue constructs to replace or restore diseased or injured skeletal muscle tissues in the body. Several biomaterials and microscale technologies have been used in muscle tissue engineering. However, it is still challenging to mimic the function and structure of the native muscle tissues. Three-dimensional (3D) bioprinting is a powerful tool to mimic the hierarchical structure of native tissues. Here, 3D bioprinting was used to fabricate tissue constructs using gelatin methacryloyl (GelMA)-alginate bioinks. Mechanical and rheological properties of GelMA-alginate hydrogels were characterized. C2C12 myoblasts at the density 8 × 106 cells/mL... 

We consider the problem of interference management in wireless cellular networks with caches at both base stations and receivers, and we characterize the degrees of freedom (DoFs) per cell to within an additive gap of (1/3) and a multiplicative gap of 2 for all system parameters, under one-shot linear schemes. Our result indicates that the one-shot linear DoF per cell scales linearly with the total amount of cache available in the cell, i.e., the sum of the caches at the central base station and all the receivers within the cell, resembling a similar phenomenon previously observed for the case of fully connected wireless networks. To establish the result, we propose a decentralized and... 

We are introducing a new type of membrane, called neuro-skin or neuro-membrane. It is comprised of neurons embedded in a plastic membrane. The skin is smart and adaptive and is capable of providing desirable response to inputs intelligently. This way, the neuro-skin can be considered as a new type of neural network with adaptivity and learning capabilities. However, in this paper, only the response of neuro-skins to a dynamic input is studied. The membrane is modelled by nonlinear dynamic finite elements. Each finite element is considered as a cell of the neuro-skin which has a neuron. The neuron is the intelligent nucleus of the element. So, the finite elements are called finite... 

This paper presents a single-ended low-power 7T SRAM cell in FinFET technology. This cell enhances read performance by isolating the storage node from the read path. Moreover, disconnecting the feedback path of the cross-coupled inverters during the write operation enhances WSNM by nearly 7.7X in comparison with the conventional 8T SRAM cell. By using only one bit-line, this cell reduces power consumption and PDP compared to the conventional 8T SRAM cell by 82% and 35%, respectively. © 2018 Elsevier GmbH  

Hydrostatic pressure is one of the most fundamental and common mechanical stimuli in the body, playing a critical role in the homeostasis of all organ systems. Kidney function is affected by high blood pressure, namely hypertension, by the increased pressure acting on the glomerular capillary walls. This general effect of hypertension is diagnosed as a chronic disease, but underlying mechanistic causes are still not well understood. This paper reports a portable and adaptive device for studying the effects of hydrostatic pressure on a monolayer of cells. The fabricated device fits within a conventional incubation system and microscope. The effects of various pressures and durations were... 

Cell lysis is an essential primary step in cell assays. In the process of cell lysis, the cell membrane is destroyed and the substances inside the cell are extracted. By utilizing a droplet-based microfluidic platform for cell lysis, the mixer unit that is required for mixing lysis reagents with the cells can be excluded, and thus, the complexity of the fabrication process is reduced. In addition, lysing the cells within the droplets will prevent the cells from exposure to the channel walls, and as a result, cleanliness of the samples and the device is maintained. In this study, cell lysis within the droplets and the parameters affecting the efficiency of this process are investigated using... 

Massive multiple-input multiple-output (M-MIMO) is recognized as a promising technology for the next generation of wireless networks because of its potential to increase the spectral efficiency. In initial studies of M-MIMO, the system has been considered to be perfectly synchronized throughout the entire cells. However, perfect synchronization may be hard to attain in practice. Therefore, we study a M-MIMO system whose cells are not synchronous to each other, while transmissions in a cell are still synchronous. We analyze an asynchronous downlink M-MIMO system in terms of the coverage probability and the ergodic rate by means of the stochastic geometry tool. For comparison, we also obtain... 

Lactobacillus acidophilus is one of the major microorganisms which are famous for their effects on cholesterol. In this study, we have investigated the effect of L. acidophilus ATCC 1643 on removing the milk cholesterol and additionally, we have immobilized L. acidophilus ATCC1643 cells in sodium-alginate and observed its effect on milk cholesterol removing. Also, we have researched about the effect of some factors including: bacteria cells number (both free and immobilized cells) and immobilized cells bead size on cholesterol removing rate and ultimately the extracted results were compared together. The results indicated that free cells could reduce cholesterol to lower than 0.5mg/100ml... 

The desire to regenerate and repair native tissues can be immediately performed by multiple tissue engineering procedures. Gelatin and alginate are biocompatible and biodegradable polymers. The addition of ZrO2 nanoparticles (NPs) into the alginate-gelatin hydrogel is considered to improve mechanical and chemical properties. Therefore, nanocomposite hydrogels have been manufactured by the freeze-drying procedure utilizing oxidized alginate-gelatin with ZrO2 NPs as a reinforcement. The fabricated nanocomposite hydrogels were character-ized by FTIR, FESEM, and rheometer. The hydrogels containing a higher ZrO2 NPs content (1.5%) have better mechanical properties than the hydrogels without NPs.... 

Gelatin methacrylate (GelMA) was proved to be a promising bioink for corneal stromal cell delivery. However, GelMA has low mechanical properties which makes it difficult to be suturable and handled for clinical applicattion. In this study, three different ratios of 12.5 % GelMA and 10 % PEGDA were investigated for corneal stromal cells delivery. The mixture containing 75 % GelMA and 25 % PEGDA (75G25P) was found to have reasonable cell viability and suturing strength. Moreover, collagen nanofibers were incorporated into 75G25P hydrogel to improve the mechanical and biomimetic properties of the construct (75G25P-E). A hybrid structure was obtained by injecting the optimized bioink on the... 

In this study, a general 3D distributed modeling of Trolling-Mode AFM (TR-AFM) as a nanorobot is presented to analyze the 2D manipulation process of a spherical cell. To this aim, the analysis is categorized into 3 sections. In the first section, 6 deformations of TR-AFM are taken into account, and the standard model of the system is obtained. Moreover, the system is simulated in ANSYS Workbench. The results of modal and transient analyses of the system from both analytical and software methods reveal high agreement, which confirms the accuracy of the presented analytical model. In the second section, by utilizing the 3D derived model, displacement of a spherical yeast single cell (W303)... 

Cascaded split-source inverter (CSSI) is a new single-stage modular multilevel topology. Each cell of this converter converts DC to AC power in the buck or boost operation mode without any additional power switch. This paper develops a design method based on a detailed model for CSSI. This model shows that energy storage elements experience double-fundamental frequency ripples besides high-frequency ones. It accurately calculates voltage gains and capacitor voltage and inductor current ripples. On the other hand, common carrier-based multilevel modulations have been modified in terms of both reference and carrier signals to control the inverter under symmetric and asymmetric conditions. With... 

Cells docking inside microfluidic devices is effective in studying cell biology, cell-based biosensing, as well as drug screening. Furthermore, single cell and regularly cells docking inside the microstructure of microfluidic systems are advantageous in different analyses of single cells exposed to equal drug concentration and mechanical stimulus. In this study, we investigated bottom wall microgrooves with semicircular and rectangular geometries with different sizes which are suitable for single cell docking along the length of the microgroove in x-direction and numerous cells docking regularly in one line inside the microgroove in a 3D microchannel. We used computational fluid dynamics to... 

With an ageing population, hearing disorders are predicted to rise considerably in the following decades. Thus, developing a new class of artificial auditory system has been highlighted as one of the most exciting research topics for biomedical applications. Herein, a design of a biocompatible piezoresistive-based artificial hair cell sensor is presented consisting of a highly flexible and conductive polyvinyl alcohol (PVA) nanocomposite with vertical graphene nanosheets (VGNs). The bilayer hydrogel sensor demonstrates excellent performance to mimic biological hair cells, responding to acoustic stimuli in the audible range between 60 Hz to 20 kHz. The sensor output demonstrates stable... 

Cells docking inside microfluidic devices is effective in studying cell biology, cell-based biosensing, as well as drug screening. Furthermore, single cell and regularly cells docking inside the microstructure of microfluidic systems are advantageous in different analyses of single cells exposed to equal drug concentration and mechanical stimulus. In this study, we investigated bottom wall microgrooves with semicircular and rectangular geometries with different sizes which are suitable for single cell docking along the length of the microgroove in x-direction and numerous cells docking regularly in one line inside the microgroove in a 3D microchannel. We used computational fluid dynamics to... 

With an ageing population, hearing disorders are predicted to rise considerably in the following decades. Thus, developing a new class of artificial auditory system has been highlighted as one of the most exciting research topics for biomedical applications. Herein, a design of a biocompatible piezoresistive-based artificial hair cell sensor is presented consisting of a highly flexible and conductive polyvinyl alcohol (PVA) nanocomposite with vertical graphene nanosheets (VGNs). The bilayer hydrogel sensor demonstrates excellent performance to mimic biological hair cells, responding to acoustic stimuli in the audible range between 60 Hz to 20 kHz. The sensor output demonstrates stable...