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Particles in coronary circulation: A review on modelling for drug carrier design
, Article Materials and Design ; Volume 216 , 2022 ; 02641275 (ISSN) ; Ghoytasi, I ; Shamloo, A ; Ghosi, S ; Sharif University of Technology
Elsevier Ltd
2022
Abstract
Atherosclerotic plaques and thrombosis are chronic inflammatory complications and the main manifestations of cardiovascular diseases (CVD), the leading cause of death globally. Achieving non/minimal-invasive therapeutic means for these implications in the coronary network is vital and has become an interdisciplinary concern. Accordingly, smart drug delivery systems, specifically based on micro- and nanoparticles, as a promising method to offer non/minimal-invasive therapeutic mechanisms are under active research. Notably, computational models enable us to study, design, and predict treatment strategies based on smart drug delivery systems with less time and cost compared with conventional...
Plaque structure affects mechanical stress distribution within blood vessels
, Article Proceedings of the IASTED International Conference on Biomedical Engineering, BioMed 2014 ; 2014 , pp. 239-243 ; Mehboudi, N ; Abdollahi, M ; Shamloo, A ; Naghdabadi, R ; Sharif University of Technology
Abstract
The main goal of this study is to investigate the effects of plaque structure on its stress distribution. Rupture of plaque causes cerebrovascular diseases which lead to high mortality rates all over the world. Computers are powerful tools to understand the mechanism of plaque rupture. In this study, 3D fluid structure interaction simulation is constructed in ABAQUS 6.13 to clarify the relation between stress distribution of plaque and its structure. A model of common carotid artery with distributed stenosis was chosen for the simulation. To investigate the effects of plaque structure on stress distribution, thickness of fibrous cap and lipid core size were varied in the stenosis....
Thickness as an important parameter in designing vascular grafts
, Article 2014 21st Iranian Conference on Biomedical Engineering, ICBME 2014 ; Nov , 2014 , p. 40-43 ; Shamloo, A ; Samani, S. A ; Dodel, M ; Sharif University of Technology
Abstract
The main goal of this study is to investigate the role of vascular graft thickness in wall stress gradient in anastomosis region. Atherosclerosis is a common heart disease causes high mortality rates every year. The gold standard treatment of atherosclerosis is replacing with autologous vein extracted from patient's body. Since proper autologous vein is limited, researchers have made efforts to achieve compliance engineered blood vessels. Mechanical stress has great effect on both smooth muscle cells and endothelial cells and it is considered as a stimulus in plaque formation. In this study, we evaluate the role of thickness in wall stress of anastomosis region. For this purpose, two...
Liquid-liquid equilibrium (LLE) data for ternary mixtures of {aliphatic+p-xylene+[EMpy][ESO 4]} at T=313.15K
, Article Fluid Phase Equilibria ; Volume 332 , 2012 , Pages 48-54 ; 03783812 (ISSN) ; Vossoughi, M ; Shamloo, A ; Mirkhani, S. A ; Akbari, J ; Sharif University of Technology
Elsevier
2012
Abstract
Liquid-liquid equilibrium (LLE) data for the ternary systems (heptane. +. p-xylene. +. 1-ethyl-3-methylpyridinium ethylsulfate) and (n-octane. +. p-xylene. +. 1-ethyl-3-methylpyridinium ethylsulfate) were measured at . T=. 313.15. K and atmospheric pressure. The selectivity and aromatic distribution coefficients, calculated from the equilibrium data, were used to determine if this ionic liquid can be used as a potential extracting solvent for the separation of p-xylene from heptane and n-octane. The consistency of tie-line data was ascertained by applying the Othmer-Tobias and Hand equations
Thickness as an important parameter in designing vascular grafts
, Article 2014 21st Iranian Conference on Biomedical Engineering, ICBME 2014, 26 November 2014 through 28 November 2014 ; November , 2014 , Pages 40-43 ; 9781479974177 (ISBN) ; Shamloo, A ; Samani, S. A ; Dodel, M ; Sharif University of Technology
Institute of Electrical and Electronics Engineers Inc
2014
Abstract
The main goal of this study is to investigate the role of vascular graft thickness in wall stress gradient in anastomosis region. Atherosclerosis is a common heart disease causes high mortality rates every year. The gold standard treatment of atherosclerosis is replacing with autologous vein extracted from patient's body. Since proper autologous vein is limited, researchers have made efforts to achieve compliance engineered blood vessels. Mechanical stress has great effect on both smooth muscle cells and endothelial cells and it is considered as a stimulus in plaque formation. In this study, we evaluate the role of thickness in wall stress of anastomosis region. For this purpose, two...
Toward epileptic brain region detection based on magnetic nanoparticle patterning
, Article Sensors (Switzerland) ; Volume 15, Issue 9 , September , 2015 , Pages 24409-24427 ; 14248220 (ISSN) ; Shamloo, A ; Alasty, A ; Ghafar Zadeh, E ; Sharif University of Technology
MDPI AG
2015
Abstract
Resection of the epilepsy foci is the best treatment for more than 15% of epileptic patients or 50% of patients who are refractory to all forms of medical treatment. Accurate mapping of the locations of epileptic neuronal networks can result in the complete resection of epileptic foci. Even though currently electroencephalography is the best technique for mapping the epileptic focus, it cannot define the boundary of epilepsy that accurately. Herein we put forward a new accurate brain mapping technique using superparamagnetic nanoparticles (SPMNs). The main hypothesis in this new approach is the creation of super-paramagnetic aggregates in the epileptic foci due to high electrical and...
Steered molecular dynamic simulation approaches for computing the blood brain barrier (BBB) diffusion coefficient
, Article IFMBE Proceedings ; Volume 51 , 2015 , Pages 1699-1703 ; 16800737 (ISSN) ; 9783319193878 (ISBN) ; Shamloo, A ; Alasti, A ; Zadeh, E. G ; Jaffray D. A ; Sharif University of Technology
Springer Verlag
2015
Abstract
In the recent years a great attention of research deals with different physical and biological aspects of the BBB structure, a robust shield that separates the blood and brain, a recent research held by the authors of this paper has focused on figuring out computing the diffusion coefficient of endothelial cell membrane. In this study, the major efforts have been concentrated on calculating a standardized measure for the amount of permeability and diffusion of this barrier. As a result, this work is dedicated to molecular dynamics (MD) simulation of calculating the interaction force between nano-particle and BBB membrane. data is recorded by using steered molecular dynamics simulation and...
Superparamagnetic nanoparticles for epilepsy detection
, Article World Congress on Medical Physics and Biomedical Engineering, 2015, 7 June 2015 through 12 June 2015 ; Volume 51 , June , 2015 , Pages 1237-1240 ; 16800737 (ISSN) ; 9783319193878 (ISBN) ; Shamloo, A ; Alasty, A ; Ghafar Zadeh, E ; Jaffray D. A ; Sharif University of Technology
Springer Verlag
2015
Abstract
Epilepsy is the most common neurological disorder that is known with uncontrolled seizure. Around 30% of patients with epilepsy resist to all forms of medical treatments and therefore, the removal of epileptic brain tissue is the only solution to get these patients free from chronical seizures. The precise detection of an epileptic zone is key to its treatment. In this paper, we propose a method of epilepsy detection using brain magnetic field. The possibility of superparamagnetic nanoparticle (SPMN) as sensors for the detection of the epileptic area inside the brain is investigated. The aggregation of nanoparticles in the weak magnetic field of epileptic brain is modeled using potential...
A computational model for estimation of mechanical parameters in chemotactic endothelial cells
, Article Scientia Iranica ; Volume 23, Issue 1 , 2016 , Pages 260-267 ; 10263098 (ISSN) ; Shamloo, A ; Azimi, S ; Abeddoust, M ; Saidi, M.S ; Sharif University of Technology
Sharif University of Technology
Abstract
A cell migration numerical simulation is presented to mimic the motility of endothelial cells subjected to the concentration gradients of a Forebrain embryoniccortical neuron Conditioned Medium (CM). This factor was previously shflown to induce the directional chemotaxis of endothelial cells with an over-expressed G protein coupled receptor 124 (GPR 124). A cell simulator program incorporates basic elements of the cell cytoskeleton, including membrane, nucleus and cytoskeleton. The developed 2D cell model is capable of responding to concentration gradients of biochemical factors by changing the cytoskeleton arrangement. Random walk force, cell drag force and cell inertial effects are also...
Dual improvement of DNA-directed antibody immobilization utilizing magnetic fishing and a polyamine coated surface
, Article RSC Advances ; Volume 6, Issue 112 , 2016 , Pages 111210-111216 ; 20462069 (ISSN) ; Soleimani, M ; Shamloo, A ; Mahmoudifard, M ; Vossoughi, M ; Sharif University of Technology
Royal Society of Chemistry
2016
Abstract
The present study is aimed at the development of a novel approach based on the magnetic improvement of DNA-directed antibody immobilization to prepare a highly efficient sensing platform. Magnetic nanoparticle substrates with high surface area capture the dual DNA-conjugated antibodies in a solution. This allows overcoming the typical mass transport limitation of the surface-based antibody immobilization. Antibody-magnetic nanoparticle conjugation is based on a robust hybridization between a DNA tether (attached to the antibody) and its complementary sequence (immobilized on the nanoparticle). Conventional antibody immobilization for the detection of proteins is often insignificant for the...
Antimicrobial wound dressing containing silver sulfadiazine with high biocompatibility: In vitro study
, Article Artificial Organs ; Volume 40, Issue 8 , 2016 , Pages 765-773 ; 0160564X (ISSN) ; Shamloo, A ; Aghababaei, Z ; Vossoughi, M ; Moravvej, H ; Sharif University of Technology
Blackwell Publishing Inc
Abstract
Many patients all over the world suffer from acute wounds caused by traumas or burns. In most crucial cases, skin regeneration cannot be promoted spontaneously, and skin grafts are applied as the main treatment. However, this therapy has some drawbacks which motivate researchers to develop wound dressings. In this study, electrospun mats consisting of polycaprolactone (PCL) and polyvinyl alcohol (PVA) incorporated with silver sulfadiazine (SSD) are proposed to be used as antimicrobial wound dressings with the capability of cell seeding. Various amounts of SSD were loaded into PVA nanofibers, and the effects of SSD particles on the morphological characteristics of nanofibers, mechanical...
Optimal magnetic field for crossing super-para-magnetic nanoparticles through the Brain Blood Barrier: A computational approach
, Article Biosensors ; Volume 6, Issue 2 , 2016 ; 20796374 (ISSN) ; Shamloo, A ; Alasty, A ; Ghafar Zadeh, E ; Sharif University of Technology
MDPI AG
2016
Abstract
This paper scrutinizes the magnetic field effect to deliver the superparamagnetic nanoparticles (SPMNs) through the Blood Brain Barrier (BBB). Herein we study the interaction between the nanoparticle (NP) and BBB membrane using Molecular Dynamic (MD) techniques. The MD model is used to enhance our understanding of the dynamic behavior of SPMNs crossing the endothelial cells in the presence of a gradient magnetic field. Actuation of NPs under weak magnetic field offers the great advantage of a non-invasive drug delivery without the risk of causing injury to the brain. Furthermore, a weak magnetic portable stimulator can be developed using low complexity prototyping techniques. Based on MD...
Molecular dynamics simulation of the dissociation mechanism of P-selectin from PSGL-1
, Article Journal of Theoretical and Computational Chemistry ; Volume 16, Issue 4 , 2017 ; 02196336 (ISSN) ; Niroomand Oscuii, H ; Nikbin, E ; Shamloo, A ; Sharif University of Technology
World Scientific Publishing Co. Pte Ltd
2017
Abstract
Interactions between P-selectin, expressed on activated endothelium, and its counterpart P-selectin glycoprotein ligand-1 (PSGL-1), expressed on leukocytes, play a pivotal role in adhesive events that recruit circulating leukocytes toward inflamed or injured tissues. Atomistic understanding of the association and dissociation of these bonds under blood flow is necessary to define the underlying mechanism. In this study, steered molecular dynamics (SMD) simulations were applied to investigate the conformational changes of P-LE/SGP-3 construct (an effective binding unit of the P-selectin/PSGL-1 complex) under stretching with constant velocity. In the present simulations, a self-built force...
Dynamic analysis of magnetic nanoparticles crossing cell membrane
, Article Journal of Magnetism and Magnetic Materials ; Volume 429 , 2017 , Pages 372-378 ; 03048853 (ISSN) ; Shamloo, A ; Ghafar Zadeh, E ; Alasty, A ; Sharif University of Technology
Elsevier B.V
2017
Abstract
Nowadays, nanoparticles (NPs) are used in a variety of biomedical applications including brain disease diagnostics and subsequent treatments. Among the various types of NPs, magnetic nanoparticles (MNPs) have been implemented by many research groups for an array of life science applications. In this paper, we studied MNPs controlled delivery into the endothelial cells using a magnetic field. Dynamics equations of MNPs were defined in the continuous domain using control theory methods and were applied to crossing the cell membrane. This study, dedicated to clinical and biomedical research applications, offers a guideline for the generation of a magnetic field required for the delivery of...
Dynamic analysis of magnetic nanoparticles crossing cell membrane
, Article Journal of Magnetism and Magnetic Materials ; Volume 422 , 2017 , Pages 464- ; 03048853 (ISSN) ; Shamloo, A ; Ghafar Zadeh, E ; Alasty, E. Y. C. A ; Sharif University of Technology
Elsevier B.V
2017
Abstract
Nowadays, nanoparticles (NPs) are used in a variety of biomedical applications including brain disease diagnostics and subsequent treatments. Among the various types of NPs, magnetic nanoparticles (MNPs) have been implemented by many research groups for an array of life science applications. In this paper, we studied MNPs controlled delivery into the endothelial cells using a magnetic field. Dynamics equations of MNPs were defined in the continuous domain using control theory methods and were applied to crossing the cell membrane. This study, dedicated to clinical and biomedical research applications, offers a guideline for the generation of a magnetic field required for the delivery of...
Three dimensional pressure transient behavior study in stress sensitive reservoirs
, Article Journal of Petroleum Science and Engineering ; Volume 152 , 2017 , Pages 204-211 ; 09204105 (ISSN) ; Shamloo, A ; Asadbegi, M ; Dezfuli, A. D ; Sharif University of Technology
Elsevier B.V
2017
Abstract
Stress sensitivity is a phenomenon that affects reservoir rock properties, such as permeability and therefore changes the well pressure transient behavior. This paper aims to study these behaviors in stress sensitive reservoirs and evaluate the pressure loss in such reservoirs during the process of hydrocarbon production. A power model is used to correlate the changes in permeability with pore pressure. A novel semi-implicit three-dimensional finite element method has been employed to numerically solve the flow problem. The numerical results have been validated by analytical results obtained in a non-sensitive reservoir. Pressure drawdown test for different scenarios has been studied. The...
Targeted pulmonary drug delivery in coronavirus disease (COVID-19) therapy: A patient-specific in silico study based on magnetic nanoparticles-coated microcarriers adhesion
, Article International Journal of Pharmaceutics ; Volume 609 , 2021 ; 03785173 (ISSN) ; Shamloo, A ; Alishiri, M ; Mozhdehbakhsh Mofrad, Y ; Akherati, F ; Sharif University of Technology
Elsevier B.V
2021
Abstract
Since the beginning of the COVID-19 pandemic, nearly most confirmed cases develop respiratory syndromes. Using targeted drug delivery by microcarriers is one of the most important noteworthy methods for delivering drugs to the involved bronchi. This study aims to investigate the performance of a drug delivery that applies microcarriers to each branch of the lung under the influence of a magnetic field. The results show that by changing the inlet velocity from constant to pulsatile, the drug delivery performance to the lungs increases by ∼31%. For transferring the microcarriers to the right side branches (LUL and LLL), placing the magnet at zero height and ∼30° angle yields the best outcome....
Green synthesis of silica nanoparticles from olive residue and investigation of their anticancer potential
, Article Nanomedicine ; Volume 16, Issue 18 , 2021 , Pages 1581-1593 ; 17435889 (ISSN) ; Afjoul, H ; Shamloo, A ; Maleki, A ; Afjoul, N ; Sharif University of Technology
Future Medicine Ltd
2021
Abstract
Graphical abstract
Drug delivery and adhesion of magnetic nanoparticles coated nanoliposomes and microbubbles to atherosclerotic plaques under magnetic and ultrasound fields
, Article Engineering Applications of Computational Fluid Mechanics ; Volume 15, Issue 1 , 2021 , Pages 1703-1725 ; 19942060 (ISSN) ; Ebrahimi, S ; Shamloo, A ; Boroumand, A ; Mofrad, M. R. K ; Sharif University of Technology
Taylor and Francis Ltd
2021
Abstract
The use of external fields such as magnet and ultrasound to enhance the targeted drug delivery (TDD) by nano-microcarriers could be a potential method. In this research, the drug delivery of magnetic nanoparticles (NPs) coated nanoliposomes and microbubbles (MBs) to the atherosclerosis plaque was investigated under magnetic and ultrasound fields in terms of their adhesion to the plaque through ligand–receptor binding. The Halbach arrangement enhanced the surface density of nanoliposomes and MBs adhered to the plaque by ∼ (Formula presented.) and ∼ (Formula presented.), respectively. A focused transducer at the power of (Formula presented.) led to better drug delivery performance and caused ∼...
Drug delivery and adhesion of magnetic nanoparticles coated nanoliposomes and microbubbles to atherosclerotic plaques under magnetic and ultrasound fields
, Article Engineering Applications of Computational Fluid Mechanics ; Volume 15, Issue 1 , 2021 , Pages 1703-1725 ; 19942060 (ISSN) ; Ebrahimi, S ; Shamloo, A ; Boroumand, A ; Mofrad, M. R. K ; Sharif University of Technology
Taylor and Francis Ltd
2021
Abstract
The use of external fields such as magnet and ultrasound to enhance the targeted drug delivery (TDD) by nano-microcarriers could be a potential method. In this research, the drug delivery of magnetic nanoparticles (NPs) coated nanoliposomes and microbubbles (MBs) to the atherosclerosis plaque was investigated under magnetic and ultrasound fields in terms of their adhesion to the plaque through ligand–receptor binding. The Halbach arrangement enhanced the surface density of nanoliposomes and MBs adhered to the plaque by ∼ (Formula presented.) and ∼ (Formula presented.), respectively. A focused transducer at the power of (Formula presented.) led to better drug delivery performance and caused ∼...