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    The Impedimetric Human Papiloma Virous DNA Biosensor Fabrication Based on Gold Nanotubes

    , Ph.D. Dissertation Sharif University of Technology Shariati, Mohsen (Author) ; Ghorbani, Mohammad (Supervisor) ; Sasanpour, Pezhman (Supervisor)
    Abstract
    An impedimetric human papilloma virus (HPV) DNA biosensor based on gold nanotubes (AuNTs) in label free detection was materialized. The AuNTs decorated nanoporous polycarbonate (AuNTs-PC) template as biosensor electrode was fabricated by electrodeposition method. The single strand DNA (ss-DNA) probe was covalently immobilized onto the AuNTs-PC electrode. The hybridization of target sequences with the ss-DNA probe was observed by the electrochemical impedance spectroscopy (EIS). The biosensor showed high selectivity and could differentiate between the complementary, mismatch and non-complementary DNA sequences. The EIS measurements were matched to Randle's equivalent circuit. The... 

    Fabrication of a Tactile Sensor Based on Triboelectric Nanogenerators

    , Ph.D. Dissertation Sharif University of Technology Zamanpour, Fahimeh (Author) ; Mohammadpour, Raheleh (Supervisor) ; Sasanpour, Pezhman (Supervisor)
    Abstract
    Humans need the five senses to understand and interact constructively with their surrounding environment; in the world of robots and intelligent systems, this is achieved using sensors. In the modern world, tactile sensors based on triboelectric effect play a prominent role in important application areas such as health monitoring, human-computer interaction, robotics, pressure mapping, and electronic signature. Triboelectric nanogenerators (TENGs) are one type of energy harvesting systems that convert mechanical energy into electrical energy. In these sensors, due to the contact and touch with the triboelectric material, an electric charge is generated and induced into the electrode, then... 

    Designing Electrophysiological Characterization System of Biological Cells Based on the Use of Nanostructured Electrodes

    , Ph.D. Dissertation Sharif University of Technology Vafaiee, Mohadeseh (Author) ; Vossoughi, Manouchehr (Supervisor) ; Sasanpour, Pezhman (Supervisor) ; Mohammadpour, Raheleh (Supervisor)
    Abstract
    In the last half century, the recording of the electrophysiological activities of the neurons has been one of the most effective methods for neuroscience development. One of the techniques used to record the activity of the nerve cells is the use of multi-electrode arrays (MEAs). Current MEAs still face limitations such as low signal-to-noise ratio (SNR) and low spatial resolution. There is a need to develop arrays that are smaller in size and have less impedance to achieve better spatial resolution and lower noise levels. The main focus of this research is on the designing and fabrication of multi-electrode arrays and improvement of their properties using nanostructures and conductive... 

    Fabrication of Gas Nanosensor based on 2D Nanostructure Titanium trisulfide/Graphene Heterojunction

    , Ph.D. Dissertation Sharif University of Technology Rafiefard, Nasim (Author) ; Iraji Zad, Azam (Supervisor) ; Sasanpour, Pezhman (Supervisor) ; Esfandiar, Ali (Co-Supervisor)
    Abstract
    Titanium trisulfide (TiS3), a transition metal chalcogenide, bears the potential to replace silicon, when taking the form of nanoflakes, due to its favorable band gap and optical response. In this work, first we investigate the response of TiS3 nanoflakes to gas detection through a careful quantum computational approach and a few succinct measurements. The computations are benchmarked and compared with a relevant experiment at each step, where their results/conclusions are discussed. The most stable surface of TiS3 particles is determined to (001), in agreement with the literature. The adsorption of 5 gas molecules is characterized through formulating and estimating their adsorption... 

    Fabrication of Triboelectric Nanogenerators based on Two-Dimensional Materials

    , M.Sc. Thesis Sharif University of Technology Ejehi, Faezeh (Author) ; Mohammadpour, Raheleh (Supervisor) ; Akhavan, Omid (Supervisor) ; Sasanpour, Pezhman (Supervisor) ; Shokrgozar, Mohammad Ali (Co-Supervisor)
    Abstract
    Triboelectric nanogenerator (TENG) works based on the accumulation of electrostatic charges produced on the surface of two dissimilar materials while they are brought into physical contact. When the surfaces are separated by a mechanical force, the induced triboelectric charges generate a potential drop, which can lead to generate an electrical current. Since their invention in 2012, TENGs have shown a rapid development in diversity of structure, amount of output power and range of applications, such as self-powered sensors, touch pads, and smart skin. Various kinds of mechanical force can be used for producing electrical energy: human motion, walking, vibration, rotating tire, wind, flowing... 

    Theoretical calculation of scattering efficiency of isotropic and anisotropic scattering particles employed in nanostructured solar cells

    , Article Journal of Optics (United Kingdom) ; Vol. 16, issue. 5 , 2014 ; ISSN: 20408978 Sasanpour, P ; Mohammadpour, R ; Sharif University of Technology
    2014
    Abstract
    Light scattering design in dye and quantum dot sensitized solar cells is one of the main concerns in enhancing their light harvesting efficiency, and also in improving their power conversion efficiency. Herein, we present a theoretical analysis to calculate the dependence of the light scattering efficiency in dye solar cells that have employed scattering agents with various sizes and morphologies incorporated in nanostructured photoanodes with different designs. Various isotropic and anisotropic nanostructures, including filled and hollow spheres, spherical voids, nanowires and hollow fibres in a size range of 100 nm to 900 nm, have been considered as scattering centres. The scattering... 

    Trap density measurement in three-dimensional nanostructured photoelectrode of titanium dioxide with various morphologies

    , Article Applied Physics A: Materials Science and Processing ; Volume 122, Issue 4 , 2016 ; 09478396 (ISSN) Sasanpour, P ; Mohammadpour, R ; Sharif University of Technology
    Springer Verlag  2016
    Abstract
    Three-dimensional TiO2 nanostructures take advantages of large surface area and superior light-harvesting efficiency, as well as appropriate charge carrier transport and separation features. Here in this research, we report for the first time on measurement of density of localized trap states in three-dimensional TiO2 nanostructures with various morphologies. Bare 1-dimensional TiO2 nanofibers have been synthesized via two different methods: electrospinning and hydrothermal processes. The surface of TiO2 nanofibrous has been modified with nanoparticles and nanobranches thorough second hydrothermal process. Various morphologies of nanostructured TiO2 have been fabricated including... 

    Fluorescent microscopy using localized excitation source with gold nanotriangles: A computational study

    , Article Photonics and Nanostructures - Fundamentals and Applications ; Volume 9, Issue 3 , 2011 , Pages 219-224 ; 15694410 (ISSN) Sasanpour, P ; Rashidian, B ; Vossoughi, M ; Sharif University of Technology
    2011
    Abstract
    A new method for fluorescent microscopy has been proposed. Proposed method uses indirect excitation of fluorophores with nanometer localized illuminating source. Localized source is created at corners of gold nanotriangles which are deposited on glass substrate. Actually the combination of gold nanotriangle (deposited on glass) acts as active substrate (where species will be placed) for our proposed method. The structure will be scanned with a focused beam of laser (or combination of beams). Due to electric field enhancement in corners and edges of nanotringle (because of surface plasmons), third order nonlinear effect will be enhanced accordingly. Enhancement in third order nonlinearity... 

    Analysis of third harmonic generation and four wave mixing in gold nanostructures by nonlinear finite difference time domain

    , Article Journal of Nanoscience and Nanotechnology ; Volume 10, Issue 11 , 2010 , Pages 7179-7182 ; 15334880 (ISSN) Sasanpour, P ; Shahmansouri, A ; Rashidian, B ; Sharif University of Technology
    2010
    Abstract
    Third order nonlinear effects and its enhancement in gold nanostructures has been numerically studied. Analysis method is based on computationally solving nonlinear Maxwell's equations, considering dispersion behavior of permittivity described by Drude model and third order nonlinear susceptibility. Simulation is done by method of nonlinear finite difference time domain method, in which nonlinear equations of electric field are solved by Newton-Raphshon method. As the main outcomes of third order nonlinear susceptibility, four wave mixing and third harmonic generation terms are produced around gold nanostructures. Results of analysis on different geometries and structures show that third... 

    Novel method for cancer cell apoptosis by localized UV light with gold nanostructures: A theoretical investigation

    , Article Nano ; Volume 5, Issue 6 , 2010 , Pages 325-332 ; 17932920 (ISSN) Sasanpour, P ; Rashidian, B ; Rashidian, B ; Vossoughi, M ; Sharif University of Technology
    2010
    Abstract
    A novel approach for phototherapy is proposed. The proposed method is based on cell apoptosis according to halting activation of cancer cell membrane receptor by exposure to UV light pulses without any side effect. In the proposed method, gold nanoparticles are directed to cancerous cells by conjugating their surface with specific ligands. UV light is created locally adjacent to cells around the gold nanoparticles. UV light is generated due to nonlinear interaction of visible light with gold nanoparticles because of enhancement in third order nonlinear effects. For example, by using 780 nm laser, 260 nm UV will be generated around the nanoparticle because of third harmonic generation... 

    Efficient geometry of surface plasmon resonance based fiber optic sensor

    , Article 2018 IEEE 38th International Conference on Electronics and Nanotechnology, ELNANO 2018 - Proceedings, 24 April 2018 through 26 April 2018 ; 2018 , Pages 351-354 ; 9781538663837 (ISBN) Abedini, M ; Ahmadi, M ; Mohammadpour, R ; Sasanpour, P ; Sharif University of Technology
    2018
    Abstract
    The efficient structure for optical fiber based surface Plasmon resonance sensor has been investigated. The sensor structure is based on removing the cladding of a multimode optical fiber and replacing it with thin film of gold. The incident light inside the fiber will excite surface plasmons which will be resulted in the absorption in specific wavelengths. The absorption behavior is dependent on the dielectric constants at the vicinity of the metallic thin film. Based on the amount of removed cladding and deposition regions on the core structure of the fiber, different configurations can be considered. Based on the computational analysis, we have studied performance of sensor for three... 

    An ultrasensitive label free human papilloma virus DNA biosensor using gold nanotubes based on nanoporous polycarbonate in electrical alignment

    , Article Analytica Chimica Acta ; 2018 ; 00032670 (ISSN) Shariati, M ; Ghorbani, M ; Sasanpour, P ; Karimizefreh, A ; Sharif University of Technology
    Elsevier B.V  2018
    Abstract
    An impedimetric human papilloma virus (HPV) DNA biosensor based on gold nanotubes (AuNTs) in label free detection was materialized. The AuNTs decorated nanoporous polycarbonate (AuNTs-PC) template as biosensor electrode was fabricated by electrodeposition method. The single strand DNA (ss-DNA) probe was covalently immobilized onto the AuNTs-PC electrode. The hybridization of target sequences with the ss-DNA probe was observed by the electrochemical impedance spectroscopy (EIS). The biosensor showed high selectivity and could differentiate between the complementary, mismatch and non-complementary DNA sequences. The EIS measurements were matched to Randle's equivalent circuit. The... 

    Gold-Plated electrode with high scratch strength for electrophysiological recordings

    , Article Scientific Reports ; Volume 9, Issue 1 , 2019 ; 20452322 (ISSN) Vafaiee, M ; Vossoughi, M ; Mohammadpour, R ; Sasanpour, P ; Sharif University of Technology
    Nature Publishing Group  2019
    Abstract
    Multi electrode arrays (MEA) have been exploited in different electrophysiological applications. In neurological applications, MEAs are the vital interfaces between neurons and the electronic circuits with dual role; transmitting electric signal to the neurons and converting neural activity to the electric signal. Since the performance of the electrodes has a direct effect on the quality of the recorded neuronal signal, as well as the stimulation, the true choice of electrode material for MEA is crucial. Gold is one of the best candidates for fabrication of MEAs due to its high electrical conductivity, biocompatibility and good chemical stability. However, noble metals such as gold do not... 

    Size and geometry of multielectrode arrays determine the efficiency of electrical interaction with neurons through double-layer capacitance

    , Article IEEE Sensors Journal ; Volume 19, Issue 8 , 2019 , Pages 2829-2836 ; 1530437X (ISSN) Vafaiee, M ; Mohammadpour, R ; Vossoughi, M ; Sasanpour, P ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2019
    Abstract
    Multielectrode array (MEA) structures are the vital parts in the interface between neural structures and external electronic circuits, both in excitation and detection. As a transducer, the performance of electrodes has direct effect on the quality of the recorded neural signal, as well as induced charge density during the stimulation in neural prosthesis. The size and geometry of the electrode structure have distinct effect on the performance of electrodes accordingly. In this paper, the effect of size and geometry of the electrodes has been investigated in their performance and the impedimetric features of the fabricated electrodes with different structures have been studied. Based on the... 

    An ultrasensitive label free human papilloma virus DNA biosensor using gold nanotubes based on nanoporous polycarbonate in electrical alignment

    , Article Analytica Chimica Acta ; Volume 1048 , 2019 , Pages 31-41 ; 00032670 (ISSN) Shariati, M ; Ghorbani, M ; Sasanpour, P ; Karimizefreh, A ; Sharif University of Technology
    Elsevier B.V  2019
    Abstract
    An impedimetric human papilloma virus (HPV) DNA biosensor based on gold nanotubes (AuNTs) in label free detection was materialized. The AuNTs decorated nanoporous polycarbonate (AuNTs-PC) template as biosensor electrode was fabricated by electrodeposition method. The single strand DNA (ss-DNA) probe was covalently immobilized onto the AuNTs-PC electrode. The hybridization of target sequences with the ss-DNA probe was observed by the electrochemical impedance spectroscopy (EIS). The biosensor showed high selectivity and could differentiate between the complementary, mismatch and non-complementary DNA sequences. The EIS measurements were matched to Randle's equivalent circuit. The... 

    DEP Force Measurement on Polystyrene Beads and Red Blood Cells Using Optical Tweezers

    , Ph.D. Dissertation Sharif University of Technology Sasanpour Yazdi, Mehrzad (Author) ; Seyed Reihani, Nader (Supervisor)
    Abstract
    In the presence of spatially non-uniform electric field, a dielectric object can experience a translational force which is known as Dielectrophoresis (DEP) force. DEP is one of the most applicable methods in sorting mechanism of different biological cells. Moreover accurately measuring the DEP force in single cell level can lead to a valuable knwoledge about the electrical properties of various cells.In this thesis, first, the other electrokinetic forces in which the Electro-Osmosis (EO) force is the important one, have to be eliminated. Regarding that this effect is strongly dependent on the frequency of external E field, we have applied the external electric field at appropriate frequency... 

    Optimization of sputtering parameters for the deposition of low resistivity indium tin oxide thin films

    , Article Acta Metallurgica Sinica (English Letters) ; Vol. 27, issue. 2 , Apr , 2014 , p. 324-330 Yasrebi, N ; Bagheri, B ; Yazdanfar, P ; Rashidian, B ; Sasanpour, P ; Sharif University of Technology
    2014
    Abstract
    Indium tin oxide (ITO) thin films have been deposited using RF sputtering technique at different pressures, RF powers, and substrate temperatures. Variations in surface morphology, optical properties, and film resistances were measured and analyzed. It is shown that a very low value of sheet resistance (1.96 ω/sq.) can be achieved with suitable arrangement of the deposition experiments. First, at constant RF power, deposition at different pressure values is done, and the condition for achieving minimum sheet resistance (26.43 ω/sq.) is found. In the next step, different values of RF powers are tried, while keeping the pressure fixed on the previously found minimum point (1-2 Pa). Finally,... 

    A possible anticancer drug delivery system based on carbon nanotube-dendrimer hybrid nanomaterials

    , Article Journal of Materials Chemistry ; Volume 21, Issue 39 , 2011 , Pages 15456-15463 ; 09599428 (ISSN) Mehdipoor, E ; Adeli, M ; Bavadi, M ; Sasanpour, P ; Rashidian, B ; Sharif University of Technology
    2011
    Abstract
    Iron oxide nanoparticles, γ-Fe2O3NP, were deposited onto the surface of multi-walled carbon nanotubes and CNT/γ-Fe2O3NP hybrid nanomaterials were obtained. Then linear-dendritic ABA type block copolymers consisting of polyethylene glycol as B block and poly(citric acid) as A block, PCA-PEG-PCA, were synthesized and cisplatin (cis-diamminedichloroplatinum (CDDP) - a platinum-based chemotherapy drug) was conjugated with their carboxyl functional groups and CDDP/PCA-PEG-PCA anticancer prodrugs were prepared. Noncovalent interactions between CDDP/PCA-PEG-PCA anticancer prodrugs and CNT/γ-Fe2O3NP hybrid nanomaterials led to CDDP/PCA-PEG-PCA/CNT/γ-Fe2O3NP drug delivery systems. There are several... 

    Neural implant stimulation based on TiO2 nanostructured arrays; A multiphysics modeling verification

    , Article IECBES 2014, Conference Proceedings - 2014 IEEE Conference on Biomedical Engineering and Sciences: "Miri, Where Engineering in Medicine and Biology and Humanity Meet", 8 December 2014 through 10 December 2014 ; December , 2015 , Pages 677-680 ; 9781479940844 (ISBN) Sasanpour, P ; Mohammadpour, R ; Amiri, K ; Silterra; University of Malaya ; Sharif University of Technology
    Institute of Electrical and Electronics Engineers Inc  2015
    Abstract
    Exploiting of the nanostructure arrays as a promising candidate for excitation of neural cells has been analyzed. Based on the importance of the coupling effect between electrode and neuron, a multiphyscis modeling approach has been proposed. The model incorporates theoretically both structural effects (size, geometry) and electrophysiological effects. The system of equations for proposed model has been solved numerically using Finite Element Method for Poisson equation and Finite Difference Method for Cable equation. In this regards we have combined the system of equations in COMSOL platform with Matlab interface accordingly. We have analyzed the effect of excitation of neuron with an extra... 

    Proper measurement of pure dielectrophoresis force acting on a RBC using optical tweezers

    , Article Biomedical Optics Express ; Volume 10, Issue 11 , 2019 , Pages 5639-5649 ; 21567085 (ISSN) Sasanpour, M ; Azadbakht, A ; Mollaei, P ; S. Reihani, N. S ; Sharif University of Technology
    OSA - The Optical Society  2019
    Abstract
    The force experienced by a neutral dielectric object in the presence of a spatially non-uniform electric field is referred to as dielectrophoresis (DEP). The proper quantification of DEP force in the single-cell level could be of great importance for the design of high-efficiency micro-fluidic systems for the separation of biological cells. In this report we show how optical tweezers can be properly utilized for proper quantification of DEP force experienced by a human RBC. By tuning the temporal frequency of the applied electric field and also performing control experiments and comparing our experimental results with that of theoretically calculated, we show that the measured force is a...