Sharif Digital Repository

In recent years, application of nanotechnology in medicine is growing rapidly, specially, in the area of drug delivery. One of most import applications of nanotechnology is the using of nanoparticles as a carrier in targeted drug delivery systems. Simulation of drug delivery and prediction of drug release are developing in experimental and industrial areas. Mathematical modeling is used in drug delivery systems because they are time and cost saving and also can be used to predict drug behavior. The aim of this research, is to provide a framework for designing nano drug carriers. To this end, uptake of nanoparticles into different types of cells with different characteristics, in different... 

In this thesis, firstly we have developed a coupled dynamic for the orbit and attitude of a solar sail. Secondly, we found an optimal trajectory from the Earth to Mars and tried to control the system on the optimal trajectory by a control mechanis which moves the center of mass of the sail. The solar sail is considered to be rigid and Ideally reflective which means the sail reflects the full extent of the photons it receives. Adjusting the center of mass of the sail is done by changing the position of two sliding masses rode on two rails perpendicular to each other. Moving the center of mass of the sail brings about a change in the attitude of the sail which then causes a deflection in the... 

Five-Level Active-Neutral-Point -Clamped (5L-ANPC) converter is used for medium-voltage and high-power applications. In many of these applications, availability and robustness against fault are the most important issues. On the other hand, this converter is made of a large number of power semiconductor switches, diodes and capacitors which could increase the failure probability. Thus, fault detection of power circuit elements is necessary for fault tolerant operation of the converter. In this thesis, following an introduction to the topology and operation principles of Five-Level Active Neutral point clamped converter, a novel open-circuit fault detection and localization method is... 

In this project, two multiscale modeling procedures have been implemented to study the mechanical behavior of SWCNT/polymer composites. First, a new three-phase molecular structural mechanics/ finite element (MSM/FE) multiscale model has been introduced which consists of three components, i.e. a carbon nanotube, an interphase layer and outer polymer matrix. The nanotube is modeled at the atomistic scale using MSM, whereas the interphase layer and polymer matrix are analyzed by the FE method. Using this model, we have investigated the macroscopic material properties of nanocomposite with and without considering the interphase and compared the results with molecular dynamics (MD) simulations.... 

Pulse forming networks (PFN) simulating an open ended transmission line, are very favorable in high energy long pulses generation, because of some benefits such as limited energy storage. However, PFN drawbacks, which are low output pulse quality and constant pulse width, limit their applications. Another limitation of generating rectangle pulses using PFN is that, half of the charged voltage appears in the output when delivering the entire energy to a matched load. In this project a new structure of PFN is presented that overcomes these limitations. For continuous pulse width adjusting, three simple schemes are proposed. By increasing load magnitude, amplitude of output pulse voltage... 

The series structure of semiconductor devices has a wide application in the industry and research field. The most critical issue in the series structure of series switches is the safe operating condition provision. Hence many kinds of research have been intensively focused on this topic to overcome this necessity. However, many existing aspects relevant to the series stacking of the semiconductor switches have not been pointed out. These include, the power loss must be accepted for the series devices and recovery of this power, providing balanced voltage for the series devices through a simple and easy implementing structure and providing a safe voltage condition for the series devices under... 

One of the most promising strategies for fighting cancer is the drug delivery process using synthetic nanoparticles. Once in biological milieu, the nanoparticle surfaces get covered with a layer of biomolecules called the “Protein Corona”. The protein corona formation changes the nanoparticles interaction with the human body dictating a new fate for them. The protein corona composition is not only dependent on the nanoparticle itself, but also it is affected by the health condition of patients as recently discovered through the experimental studies. Here, the effect of disease on the protein corona formation is discussed through the molecular dynamics simulations. A multiscale simulation... 

The purpose of this thesis is design of an adaptive tracking control for input-quantized strict-feedback fractional order nonlinear systems with unknown dynamics and asymmetric time-varying output constraints. The controller design is achieved by using a hysteretic quantizer to avoid chattering and not needing the quantization parameters. The fuzzy logic method has been used to solve the problem of unknown dynamics. Also, due to the asymmetric time-varying output constraints, the Barrier Lyapunov function has been used. In this thesis, less restrictive assumptions have been considered than the work performed in previous researches.By utilizing the adaptive backstepping approach and based on... 

Based on the new standards, less than 10 ppm sulfur is allowed for the automotive fuels. This has led researchers to try improving the present conventional methods as well as seeking alternative routes for refinement of the petroleum products so much to comply with the requirements. Since thiophenic fragments such as dibenzothiophene (DBT) are the most durable sulfur compounds in the current hydrodisulfurization method, many studies have been conducted over recent years on how to remove these compounds. In this thesis, the desulfurization of dibenzothiophene from gasoline via adsorption method was studied. In order to carry out the adsorption process, a nanocomposite of graphitic-carbon... 

Selective Laser Sintering (SLS) is one of the powder-based Additive Manufacturing (AM) technology in which parts built by CO2 laser. In this research work, Titanium-PMMA-Stearic Acid powders are mixed together to produce parts by Indirect Metal Laser Sintering (IMLS) method. The optimum process parameters such as energy density, Percentage composition of Titanium-PMMA and Scan Sintering are obtained by adopting the Taguchi method for getting the maximum density and minimum porosity. Experiments are planned by Taguchi’s Mix-L8 orthogonal array. According to the results obtained from this study, the percentage of combination Ti-PMMA and Energy density, respectively, are a major parameters that... 

The magnetic MOF-based catalytic system has been reported here to be an efficient catalyst for synthesis of carbamates under optimal conditions. The robust MOF catalyst was built based on magnetic nanoparticles and HKUST-1 which further modified with thioacetamide and carbonization. The catalyst structure was confirmed by various techniques. Furthermore, the products’ yields were obtained in good to excellent for all reactions under mild conditions which result from superior activity of the synthesized heterogeneous catalyst containing Cupper. Also, the magnetic property of the MOF-based catalyst makes it easy to separate from reaction mediums and reuse in the next runs. In summary, the...