Sharif Digital Repository

Respiratory drug delivery has been under the research spotlight for the past few decades, mainly due to the high incidence of pulmonary diseases and the fact that this type of delivery offers the highest efficiency for treatment. Despite its invaluable benefits, there are some major drawbacks to respiratory drug delivery, the most important of which being poor delivery efficiency and relatively high drug deposition in undesirable regions, such as the mouth cavity. One way to improve the efficiency of respiratory drug delivery with metered-dose inhalers is placing a respiratory spacer between the inhaler exit and the mouth. It is argued that high drug deposition in the immediate airways of... 

The inflow pattern of liquid into a droplet is studied experimentally using a surface active dye and compared with results of CFD simulations. The results show visual agreement between experiments and simulations. The CFD simulations show also good agreement with the surface tension measured by drop profile analysis tensiometry (PAT). The inflow of the surfactant induces a Marangoni instability caused by the local arrival of the surfactant at the drop surface. The onset of this Marangoni instability observed experimentally has a delay of about 10. s when compared with the simulation results. Different scenarios are discussed, including a boundary layer barrier, a kinetic-controlled... 

Dilational and shear viscoelasticities are important properties of interfacial layers. These quantities are particularly relevant in all systems which contain a huge internal interfacial area such as foams and emulsions. Therefore, also the 3D rheological behavior of foams or emulsions studied by respective methods is superimposed by the 2D interfacial rheology.We report on recent developments in dilational and shear rheology from an experimental point of view as well as discuss the state of the art of the underlying theories. Examples of most relevant experiments are also presented and discussed. Although not yet extensively investigated, the links between bulk rheology of foams and... 

The effects of particle size on the solid flow pattern in gas-solid bubbling fluidized beds were investigated numerically using two-fluid model based on the kinetic theory of granular flow. In this regard, the set of governing equations was solved using finite volume method in two-dimensional Cartesian coordinate system. Glass bead particles with mean sizes of 880. μm, 500. μm, and 351. μm were fluidized by air flow at excess gas velocities of 0.2. m/s and 0.4. m/s. For particle diameters of 880 and 351. μm, the predicted characteristic times for solid dispersion were 0.14. s and 0.15. s, respectively, while characteristic times for solid diffusivity were 1.68. ms and 0.75. ms in the same... 

Within elasticity theory, the reduced form of a displacement field is obtained for general cross-ply composite laminates subjected to a bending moment. The firstorder shear deformation theory of plates and Reddy's layerwise theory are then utilized to determine the global deformation parameters and the local deformation parameters appearing in the displacement fields, respectively. For a special set of boundary conditions an elasticity solution is developed to verify the validity and accuracy of the layerwise theory. Finally, various numerical results are presented within the layerwise theory for edge-effect problems of several cross-ply laminates under the bending moment. The results... 

In this paper, using an analytical optimization method, optimum design of multi-layer compound cylinders with different materials in layers is investigated. For this purpose, considering Tresca criterion, maximum shear stress in each layer is minimized. At the optimum condition, the maximum shear stress at all layers occurs simultaneously. The general analytical relations for optimum dimension of layers, residual pressures and radial interferences are derived. The existence condition of the optimum solution is also investigated and the constraints for materials selection are derived too. It is shown that the allowable shear stress ratio of materials must be close to their geometric mean... 

An anatomically detailed eighteen-rotational-degrees-of-freedom model of the human spine using optimization constrained to equilibrium and stability requirements is developed and used to simulate several symmetric tasks in upright and flexed standing postures. Predictions of this stability and kinematics-driven (S. +. KD) model for trunk muscle forces and spine compressive/shear loads are compared to those of our existing kinematics-driven (KD) model where both translational and rotational degrees-of-freedom are included but redundancy is resolved using equilibrium conditions alone. Unlike the KD model, the S. +. KD model predicted abdominal co-contractions that, in agreement with... 

This research numerically and experimentally investigates a small turbocharger radial flow compressor with a vane-less diffuser and volute. The geometry of the compressor is obtained via component scanning, through which a 3D model is prepared. The flow inside this model is numerically analyzed by using a Navier-Stokes solver with a shear-stress transport turbulence model. The characteristic curves of the compressor and the contributions of its components to total pressure drop are acquired by measuring the static and total pressures at different cross sections of the compressor. Numerical results are verified with the experimental test results. The model results exhibit good agreement with... 

In the present study, an analytical solution is proposed to determine the interlaminar stresses in long symmetric laminated composite plates subjected to shearing loads. An improved first-order shear deformation theory (IFSDT) and a simplified IFSDT (SIFSDT) are utilized to calculate the unknown constants appearing in the reduced elasticity displacement field which actually demonstrate the global deformations of the plate. Then the numerical values of the interlaminar normal and shear stresses are established through the laminates by using Reddy's layerwise theory. Finally, several numerical examples are presented to study the interlaminar stresses in the interfaces of the layers and through... 

Muscle fatigue affects the underlying EMG-force relationship on which EMG-assisted biomechanical models rely. The aim of this study was to evaluate the impact of short duration muscle fatigue on the muscle gain value. Participants performed controlled, isometric trunk extension exertions at 10, 20, and 30 degrees of trunk flexion and controlled isokinetic trunk extension exertions at 5 and 15°/sec on five separate days. Fatigue of the lumbar extensors was generated by moderate-intensity, trunk extension exertions. Participants performed controlled test contractions at defined intervals throughout the fatiguing bout and the EMG activities of trunk muscles were collected. These EMG data were... 

A novel analytical model is presented for analyzing the steady-state creep in short-fiber composites under axial load utilizing the previous shear-lag theory, the imaginary fiber technique and also new approaches of Hermite polynomials, hyperbolic trigonometric functions and power series. The steady-state creep behavior of the matrix is described by an exponential law, while the fibers behave elastically. In this model, in spite of the previous researches, some unknowns such as shear stress, displacement rates, and creep strain rates are correctly determined in all regions of the unit cell without using any further assumptions. In comparison with previous analytical approaches, the results... 

The present study provides a comparison between the flow pattern around two circular piers in tandem and a single pier set up on a moderately rough flat bed in a laboratory flume. Velocities are measured by an Acoustic Doppler Velocimeter (ADV). The contours of the time-averaged velocity components, Reynolds shear stresses, turbulence intensities and turbulence kinetic energy at different planes are presented. Streamlines and vectors are used to study the flow features. The analysis of power spectra around the piers is also presented. The results show that the presence of downstream pier changes the flow structure to a great extent, particularly in the near-wake region. Within the gap... 

In this study, at first the cardiovascular system is modeled based on the 1D method and then the simulation of the reactive hyperemia experiment has been applied on the model. In this simulation, by applying a cuff at the brachial artery, the flow downstream of the cuff is occluded. Then with releasing the cuff immediately, a large amount of shear stress, about 4 times the basal amount, is applied downstream of the cuff and consequently to the endothelial cells in a very short moment. Considering a reported experimental transfer function between shear stress and vasodilation, the increase of the artery diameter due to the sudden increase of the shear stress is obtained. Finally, the... 

In this paper, employing an analytical method, optimum design of multi-layer compound cylinders is investigated. To this end, considering Tresca criterion, maximum shear stress in each layer is minimized. Analytical relations for optimum values of a layer dimension, residual pressures and radial interferences are derived. A technique for shrink-fitting of layers is also proposed and relationships for radial interferences, residual pressures and required temperature differences during the shrink-fitting process are derived. Three different examples are presented to show the effectiveness of the proposed method. It is shown that increasing the number of layers makes shear stress distribution... 

The present study provides the experimental results of the flow pattern around two-circular piers positioned in side-by-side arrangement. The experiments were performed for two bed configurations (with and without a scour hole). Velocities were measured by an Acoustic Doppler Velocimeter (ADV). Flat bed and scour hole were frozen by synthetic glue to facilitate the performance of the experiments. The contours and distributions of the time-averaged velocity components, turbulence intensities, turbulence kinetic energy, and Reynolds stresses at different horizontal and vertical planes are presented. Streamlines and velocity vectors obtained from time-averaged velocity fields are used to show... 

The present study considers both the hydrodynamic and thermal characteristics of combined electroosmotic and pressure driven flow in a microannulus. Analytical solutions are presented using the Debye-Hückel linearization along with the uniform Joule heating and negligible viscous dissipation assumptions, whereas exact results are achieved numerically. Here, the range of validity for the Debye-Hückel linearization is found to be about two times of that for a parallel plate microchannel. Accordingly, this linearization may successfully be used to evaluate the potential and velocity distributions up to the zeta potentials of 100 mV, provided that the dimensionless Debye-Hückel parameter is... 

Injection molding is one of the most important manufacturing processes for mass production of complex plastic parts. In this study, mold filling is simulated by using the OpenFOAM software for Non- isothermal Newtonian fluid. The OpenFOAM is an open source software that is used in Computational Fluid Dynamics (CFD) tools. The studied mold shape has a rectangular structure with a gate for Newtonian fluid injection. The simulation carried out at non-isothermal conditions and two-dimensional flow is considered. The velocity, shear stress and temperature changes in different parts of the mold are critically studied. We show that vortex formation plays an important role on changes of shear stress... 

This work simulates the turbulent boundary layer of an incompressible viscous swirling flow through a conical chamber. To model the pressure gradient normal to the wall, the radial and tangential velocity components across the boundary layer have been calculated by both the integral and numerical methods. The numerical solution is accomplished by finite difference, based on the finite volume method. The results show that the radial and tangential boundary layer thicknesses depend on the velocity ratios, Reynolds number and nozzle angle. The peak of radial and tangential boundary layer thicknesses are located at zL≈0.2 and zL≈0.8 from the nozzle inlet, respectively. Due to the short length of... 

This study presents a comprehensive investigation on hydrodynamic and thermal transport properties of mixed electroosmotically and pressure driven flow in microtubes. Particular emphasis is given to investigating the combined consequences of viscous dissipation, non-uniform Joule heating, and variable thermophysical properties. Analytical solutions are obtained using the Debye-Hückel linearization and constant fluid properties assumption, while a numerical solution is presented for variable fluid properties and non-uniform distribution of Joule heating. The results indicate that, viscous heating effect is pronounced significantly when a favorable pressure gradient exists and cannot be... 

Arterial diseases, namely atherosclerosis, are believed to be a product of abnormal changes in both hemodynamic and non-hemodynamic factors. In order to explornmk,e the role of different factors in initiation and progression of this disease, a CFD technique was applied to study Interaction between the structure of the artery and blood flow for different suggested models that were used to describe mechanics of vessel wall. This study presents a three-dimensional, steady state simulation of blood flow through the single and double layered carotid artery bifurcation using fluid structure interaction (FSI) method. The wall shear stress and mechanical stress/strain are computed and analyzed under...