Sharif Digital Repository

Nowadays, all of the devices that measure blood pressure commercially at home are using wrist or arm cuffs preventing the systolic or diastolic blood pressure from being measured continuously. Various parameters such as blood flow with some degree of correlation with blood pressure that can be measured noninvasively have been suggested. However, these parameters do not produce accurate estimates for blood pressure. Pulse Transit Time (PTT) which is defined as the interval between the R peak of ECG signal and the next PPG signal valley has shown to have over 90% correlation with systolic blood pressure in past studies. In this thesis, the relationship between the value of the systolic blood... 

Detection of blood diseases is one of the hardest branches of medical science. The human circulatory system mainly consists of three main components namely white blood cells, red blood cells and platelets. Many diseases are diagnosed based on qualitative and quantitative evaluation of these cells, such as cell’s quantity, size, shape and the color of the cells. For example, AIDS and blood cancer cause major changes in components of immune system i.e. white blood cells. Also, some features of red blood cells change in various diseases such as iron deficiency, anemia, thalassemia and other diseases like malaria. Rapid diagnosis and treatment of these diseases has a considerable impact on the... 

Carotid bifurcation is one of the most important bifurcations in human body which has a lot of curvature in some people. The common carotid artery bifurcates into an internal carotid artery (ICA) and an external carotid artery (ECA). The incidence of stenosis in carotid bifurcation and in particular in the internal carotid artery is of special importance. In the United States of America by 2006, nearly 700000 strokes occur each year, with about 160000 deaths and 20 to 30% of strokes are caused by stenotic carotid that cost estimated at $160 billion. The purpose of this thesis is to investigate in hemodynamic factors of blood flow such as velocity variation, vortex patterns, shear stress and... 

Red Blood Cells (RBCs) are the main cells in human blood with a main role in mechanical properties of blood as a fluid. Several methods are developed to simulate the behavior of RBCs motion and deformation in micro-capillaries. Since in microscopic scales, using discrete models are more preferred than continuum methods, moving particle semi-implicit method (MPS) which is one of the recent innovative particle based methods, can simulate micro-fluidic flows based on Navier-Stocks equations. Although by the recent developments MPS method has turned into a considerable tool for modeling blood flow in micro-scales, but still some problems, such as commitment to use small time steps, restrict the... 

All living entities requires energy to continue their lives. In human beings this energy is provide through consumption of food, at first the consumed food gets converted to glucose and the produced glucose enters the blood and then goes to the body cells in which it is used to produce the required energy. The essential hormone which makes it possible to use Glucose for energy production is INSULIN. In the patients suffering from Type 1 Diabetes, lack of Insulin production makes it impossible for the cells to use Glucose for the production of their required energy. In these patients due to the fact that the blood Glucose is not used by the cells, the Blood Glucose Level (BGL) increases,... 

In this dissertation, mass transport in cardiovascular system has been simulated using one-dimensional approach. As one-dimensional simulation has computation cost less than that of the three-dimensional simulations, and as it is more precise than lumped models, they are extensively used in the study of the phenomena in cardiovascular system. In addition, such an approach is more useful in the extraction of medical indices. In this study, a one-dimensional geometry of the systemic arteries has been used to solve momentum and continuity equations using characteristics method.
At first, the physiological data of the systemic arteries have been used to simulate a one-dimensional geometry... 

The mathematical analysis of the kidney has always been considered due to its complex performance. It’s about two decades that mathematicians work on the mathematical modeling of this tissue. Since Glomerular filtration of blood in the kidney has been regarded by physiologists for many years, they can access only to the qualitative data. Mathematicians can solve this problem by numerical modeling. In this research, an engineering model is presented for the analysis of this capillary network by investigating in the different scientific fields such as, physiology, medicine, computer science and mathematics.First of all, the homogeneous model introduced by Deen, are studied. The rate of the... 

Trombosis formation in blood flow is a complex biochemical and very important process for body health which impedes blood loss by creating obstacles in the path of injured wall vessels. Although this phenomenon plays a very significant role in healthy body function, unfortunately it has been observed that it could cause diseases or even stroke. The reason is that thrombosis formation in blood and its detachment from the vessel wall can result in block body capillaries and lead a catastrophic event for the body. One of the factors which motivates blood for forming unnatural thrombosis is the vessel stenosis. It would ange in normal blood flow path and cause thrombosis formation as time is... 

Magnetic resonance imaging is one of non-invasive methods to measure the hemodynamic and morphologic parameters of tissues, especially brain tissues. Hemodynamic parameters monitoring in brain tissue is of significant importance in many majors such as detection of tumor occurrence, brain abnormalities, and track of treatment procedures. Blood is a suspension, comprised of plasma, red blood cells, white blood cells, platelet, etc. Plasma is a Newtonian fluid which is composed of proteins and has a constant viscosity in body temperature. Rheological properties of blood are highly dependent on mechanical and rheological properties of its cells and this dependence is multiplied in narrow vessels... 

Continuous and non-invasive blood pressure (BP) measurement systems generally utilize applanation tonometry and vascular unloading. Some of them satisfies the AAMI standards (|mean|<5, |SD|<8). Unfortunately they are hardly to be widely affordable due to the complicated mechanical structure and high production cost. Till now those devices are seldom being used in operation room and generally used in clinical researches. In 2000, a linear model using pulse transit time (PTT) to continuous and non-invasive blood pressure (BP) measurement was proposed. Due to the nonlinear performance parameters of the arteries, researchers have used nonlinear models to promote this method. Although the... 

Blood is a perishable product and can only be stored for a limited time. Reducing the level of wastage and shortage in supply chain of blood products is the main challenge of supply chain management. Wastage occurs whenever hospitals and blood banks order excessive blood while ordering insufficient amount results in shortage. Wastage can increase the costs in supply chain while shortage can cause important operation to be cancelled.This thesis presents an integer programming model for improving blood related operations in hospitals and blood banks. The presented model determines optimal order levels for each period which minimize total cost, shortage and wastage levels. The model is... 

This research is focused on inventory management of a blood banking system by assuming deterministic demand and supply with the objective function of minimizing the summation of shortage and wastage. In this research, two integer programming models are developed to solve the problem. In the first model, it is assumed that the blood groups are independent, but in the second one, the transactions between different blood groups are allowed, as it is in reality. Then, to be more efficient and practical, a dynamic heuristic algorithm is developed. In addition, we compared the solution of heuristic algorithm with the exact solutions derived from integer programming models. The data used in this... 

This thesis addresses cuff-less blood pressure (BP) estimation, for systolic blood pressure (SBP) and diastolic blood pressure (DBP) estimation with the aid of the processing of vital signals. Both with and without calibration per person approaches for BP estimation are considered. A data acquisition hardware is designed for high-resolution sampling of phonocardiogram (PCG), Photoplethysmogram (PPG) and electrocardiogram (ECG). Using these signals, pulse transit time (PTT) and pulse arrival time (PAT) indexes, which would be used for BP estimation with calibration, are extracted. For the BP estimator model using the calibration, A nonlinear model based on PTT or PAT, via modeling the vessels... 

Impedance spectroscopy is known as one of the important integrated sensing methods in micro scale Biosensors and electrochemical sensors. Recently, Impedance spectroscopy has been noticed in many micro scale applications. These micro scale applications is being developed specially in bioelectronics and biomedical. The goal of this thesis is designing an on-chip impedance spectroscope system for high frequency with 10 bits resolution via fully electrical blood glucose concentration measurement. This system extracts the blood glucose concentration data through measuring the permittivity coefficient of blood at 1 GHz frequency. In this thesis, new method for high frequency high resolution... 

A Lab-On-a-Chip (LOC) is a device which can integrate one or many laboratory functions on a small chip with millimeters to few square centimeters in size. LOC is a subset of MEMS devices and known as “Micro Total Analysis Systems” (µTAS) as well. LOC technology is closely related to microfluidics which primarily describes the physics, manipulation and study of minute amount of fluids.In this research we tried to simulate the performance of a microfluidic device for counting blood cells to find main factors of it for design and manufacturing. This research has two main sections, hydrodynamics of fluid inside the microchannels and finding electrical performance of designed Coulter counter for... 

Continuous Blood Pressure monitoring can provide invaluable information about individuals’ health conditions. However, BP is conventionally measured using inconvenient cuff-based instruments, which prevents continuous BP monitoring. This work presents an efficient algorithm, based on the Pulse Arrival Time (PAT), for the continuous and cuff-less estimation of the Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), and Mean Arterial Pressure (MAP) values. The proposed framework estimates the BP values through processing vital signals and extracting two types of features, which are based on either physiological parameters or whole-based representation of vital signals. Finally, the... 

Hypertension precvalence is 24 and 20.5 percent in men and women, respectively. Continuous Blood Pressure monitoring can provide invaluable information about individuals’ health conditions. However, BP is conventionally measured using inconvenient cuff-based instruments, which prevents continuous BP monitoring. This work presents an efficient algorithm, based on the Pulse Arrival Time (PAT), extracted from Electrocardiogram (ECG) and Photopletysmograph (PPG), for the continuous and cuff-less estimation of the Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), and Mean Arterial Pressure (MAP) values. Methods: The proposed framework estimates the BP values through processing vital... 

Red blood cells (RBC, erythrocytes) are cells with an average diameter of 8 microns, the thickness of 2-3 microns and the volume of 90 fl. The biconcave shape of red blood cells,together with cell membrane flexibility, enables them to pass the capillaries whose diameter is considerably less than 8 micrometers. Mechanical properties of RBC are related to their membrane and cytoskeleton, which consists of spectrin network. Optical tweezers is able to exert very precise forces to erythrocytes using beed as a handle. In this report, we studied mechanical properties of RBC such as elasticity and viscoelasticity using single trap optical tweezers with beads with antibody coated in order to attach... 

Blood is one of the most important biological organs. Red blood cell (RBC), as the most abundant cell of blood, plays an important role at life of the living bodies. Unique mechanical properties of RBCs enable them to pass through very narrow vessels. Any abnormality in these mechanical properties will disorder the function of the cell and many diseases affect these properties too. Studying the mechanical properties of RBCs is very importantin that it could result in a disease diagnostic method in a single-cell level. In this thesis we have tried to measure the viscoelastic properties of a single RBC by an optical trap through a passive method. This measurement is made through studying the... 

The heart is a powerful muscle whose primary function is to pump blood into the body. many cardiac patients reach a stage that can no longer be kept function of their heart to a satisfactory level by using medication thus doctors undergo surgery. The common problem occurs to most patients undergoing cardiac surgery is that after the surgery, the patient's heart during a short period of time is unable to supply blood with the flow rate and pressure required for all organs, especially the end organs of the body. In this conditions, ventricular assist device help the patients. These devices are used parallel with patient’s heart and supply the large portion of blood that patient’s body needs....