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bilayer-scaffold
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Fabrication and Optimizing a Bilayer Scaffold with the Ability to Release Growth Factors in Aim to Treating Injuries in Tissue Engineering
, M.Sc. Thesis Sharif University of Technology ; Shamloo, Amir (Supervisor) ; Hosseini, Vahid (Supervisor)
Abstract
Skin, as the largest organ of the body and the first protector against external injuries, plays an important role in maintaining human health. Therefore, providing a method for complete treatment of skin lesions is very important. In the last century, tissue engineering approaches, with the introduction of skin scaffolds, have been instrumental in the process of skin tissue regeneration and treatment. The aim of the present study is to construct an optimal bilayer scaffold to mimic the two outer layer of the skin (epidermis and dermis). Besides, the effects of placenta extract on acceleration of wound healing was investigated by an in-vivo test. both layer of scaffold are porous hydrogels,...
Bilayered heparinized vascular graft fabricated by combining electrospinning and freeze drying methods
, Article Materials Science and Engineering C ; Volume 94 , 2019 , Pages 1067-1076 ; 09284931 (ISSN) ; Shamloo, A ; Sharif University of Technology
Elsevier Ltd
2019
Abstract
Small diameter vascular grafts (<6 mm) are highly demanded for patients suffering from severe occluded arteries to be used as a bypass or substituted conduit. Fabricating a graft with appropriate structural, mechanical and cell growth properties which has simultaneously anti-thrombogenic trait is a challenge nowadays. Here, we proposed a bilayer heparinized vascular graft that can mimic the structural and mechanical characteristics close to those of the native coronary artery by combining electrospinning and freeze drying methods. In this study, the inner layer was made by co-electrospinning of synthetic polymer, poly-caprolactone (PCL) and the natural polymer, gelatin (Gel). Also, heparin...
Bilayered heparinized vascular graft fabricated by combining electrospinning and freeze drying methods
, Article Materials Science and Engineering C ; Volume 94 , 2019 , Pages 1067-1076 ; 09284931 (ISSN) ; Shamloo, A ; Sharif University of Technology
Elsevier Ltd
2019
Abstract
Small diameter vascular grafts (<6 mm) are highly demanded for patients suffering from severe occluded arteries to be used as a bypass or substituted conduit. Fabricating a graft with appropriate structural, mechanical and cell growth properties which has simultaneously anti-thrombogenic trait is a challenge nowadays. Here, we proposed a bilayer heparinized vascular graft that can mimic the structural and mechanical characteristics close to those of the native coronary artery by combining electrospinning and freeze drying methods. In this study, the inner layer was made by co-electrospinning of synthetic polymer, poly-caprolactone (PCL) and the natural polymer, gelatin (Gel). Also, heparin...
Fabrication and evaluation of a bilayer hydrogel-electrospinning scaffold prepared by the freeze-gelation method
, Article Journal of Biomechanics ; Volume 98 , 2020 ; Shamloo, A ; Sharif University of Technology
Elsevier Ltd
2020
Abstract
This study presents a bilayer structure as a skin scaffold comprised of an electrospun sheet layer made of polycaprolactone and polyvinil alcohol and a porous hydrogel layer made of chitosan and gelatin. The hydrogel layer was fabricated by employing the freeze-gelation technique. The bilayer structure was achieved by pouring the hydrogel solution on the electrospun sheet at the bottom of a mold followed by the freeze-gelation technique to obtain a porous structure in the hydrogel. The hydrogel and hydrogel-electrospun samples were characterized by scanning electron microscopy, swelling, tensile strength, in vitro and in vivo analyses. From a mechanical strength standpoint, the combination...