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Investigating the Effect of Geometric Shape and Properties of Protein Corona on Drug Release Using Finite Element Method

Mohammadi Hosseinabadi, Hossein | 2019

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 51638 (08)
  4. University: Sharif University of Technology
  5. Department: Mechanical Engineering
  6. Advisor(s): Naghdabadi, Reza
  7. Abstract:
  8. In novel drug delivery systems, once nanocarriers confront the biological milieu, their surface is rapidly covered with a layer of biomolecules (i.e., “protein corona”) which play an important role in their drug release rate. Various experimental studies have been done to elucidate the effect of nanoparticles properties on the drug release rate in different biological applications. The physical and geometrical properties of protein corona totally influence on the release profile. In this study, we proposed a suitable finite element model which contains the nanoparticles and the protein layer with their properties in the biological milieu. To this end, diffusion parameters including diffusion and convection coefficients and the bonding between drug molecules and the nanocarrier matrix were incorporated in the model for both nanoparticle and protein corona separately. Afterward, using different diffusion coefficients for drug molecules and an unsteady convection coefficient, we provided two improved models. Then we verified the results using the experimental studies. Using the final model, the effect of protein corona for EGRS and EC4CP nanoparticles was investigated. The results show that drug release rate increases by the growth of diffusion and convection coefficients, decrease of nanoparticle size and protein corona thickness, and increase of surface roughness and aspect ratio of nanoparticle and protein corona. Moreover, we monitored the free energy change and discussed the effect of this parameter on the drug release process. In this regard, our outputs show that increasing the free energy change due to the growth of unbound molecules results in increasing the rate of drug release
  9. Keywords:
  10. Pharmacy ; Drug Release ; Nanocarrier ; Corona Protein ; Fick's Law ; Finite Element Method

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