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Extraction of fluoxetine from aquatic and urine samples using sodium dodecyl sulfate-coated iron oxide magnetic nanoparticles followed by spectrofluorimetric determination

Bagheri, H ; Sharif University of Technology

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  1. Type of Document: Article
  2. DOI: 10.1016/j.aca.2011.02.060
  3. Abstract:
  4. A new method based on the combination of magnetic solid phase extraction (MSPE) and spectrofluorimetric determination was developed for isolation and preconcentration of fluoxetine form aquatic and biological samples using sodium dodecyl sulfate (SDS) coated Fe3O4 nanoparticles (NPs) as a sorbent. The unique properties of Fe3O4 NPs including high surface area and strong magnetism were utilized effectively in the MSPE process. Effect of different parameters influencing the extraction efficiency of fluoxetine including the amount of Fe3O4 and SDS, pH value, sample volume, extraction time, desorption solvent and time were optimized. Under optimized condition, the method was successfully applied to the extraction of fluoxetine from water and urine samples and absolute recovery amount of 85%, detection limit of 20μgL-1 and a relative standard deviation (RSD) of 1.4% were obtained. The method linear response was over a range of 50-1000μgL-1 with R2=0.9968. The relative recovery in different aquatic and urine matrices were investigated and values of 80% to 104% were obtained. The whole procedure showed to be conveniently fast, efficient and economical for extraction of fluoxetine from environmental and biological samples
  5. Keywords:
  6. Fe3O4 ; Magnetic solid phase extraction ; Spectrofluorimetry ; Urine analysis ; Water analysis ; Fe3O4 ; Body fluids ; Desorption ; Iron oxides ; Nanomagnetics ; Nanoparticles ; Optimization ; Sodium ; Sodium sulfate ; Solvent extraction ; Dodecyl sulfate sodium ; Ultrasmall superparamagnetic iron oxide ; Drug isolation ; Drug structure ; Magnetism ; PH ; Priority journal ; Solid phase extraction ; Spectrofluorometry ; Urinalysis ; water sampling ; Chemical Fractionation ; Fluoxetine ; Humans ; Hydrogen-Ion Concentration ; Magnetite Nanoparticles ; Sodium Dodecyl Sulfate ; Spectrometry, Fluorescence ; Surface-Active Agents ; Time Factors
  7. Source: Analytica Chimica Acta ; Volume 692, Issue 1-2 , 2011 , Pages 80-84 ; 00032670 (ISSN)
  8. URL: http://www.sciencedirect.com/science/article/pii/S0003267011003126