Design and Fabrication af a Bioceramic-Polymer Composite Scaffold Using Bioprinter for Regeneration of Osteochondral Tissue, M.Sc. Thesis Sharif University of Technology ; Mashayekhan, Shohreh (Supervisor)
Abstract
In this work, we have used a 3D printer and unidirectional ice-templating technique in conjunction, to fabricate a novel composite scaffold to facilitate local osteochondral defects tissue regeneration with a cell-free approach. Using ice-templating to induce radially-aligned porosity formation in type I bovine collagen is known to expedite host cells' migration into the scaffold which their ECM secretion shifts cellular milieu toward that of its neighboring tissue layer. We used numerical analysis to design and optimize appropriate freeze-casting mold, finding the optimum value for pin height and metal slab depth to be 4mm and 14mm, respectively. Collagen content equivalent to 2%w/v was...
Cataloging briefDesign and Fabrication af a Bioceramic-Polymer Composite Scaffold Using Bioprinter for Regeneration of Osteochondral Tissue, M.Sc. Thesis Sharif University of Technology ; Mashayekhan, Shohreh (Supervisor)
Abstract
In this work, we have used a 3D printer and unidirectional ice-templating technique in conjunction, to fabricate a novel composite scaffold to facilitate local osteochondral defects tissue regeneration with a cell-free approach. Using ice-templating to induce radially-aligned porosity formation in type I bovine collagen is known to expedite host cells' migration into the scaffold which their ECM secretion shifts cellular milieu toward that of its neighboring tissue layer. We used numerical analysis to design and optimize appropriate freeze-casting mold, finding the optimum value for pin height and metal slab depth to be 4mm and 14mm, respectively. Collagen content equivalent to 2%w/v was...
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