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The LiClO4-mediated synthesis of β-(dialkylamino) sulfoxides and β- (dialkylamino) sulfones by addition of α-lithiated salts of sulfoxides and sulfones to aldehydes and (trimethylsilyl)dialkylamines

Naimi Jamal, M. R ; Sharif University of Technology | 2000

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  1. Type of Document: Article
  2. DOI: 10.1002/(SICI)1099-0690(200005)2000:9<1735::AID-EJOC1735>3.0.CO;2-A
  3. Publisher: Wiley-VCH Verlag , 2000
  4. Abstract:
  5. The LiClO4-mediated one-pot reaction of aldehydes with (trimethylsilyl)dialkyl amines and the lithium salt of sulfoxides or sulfones, affords the corresponding β-(dialkylamino) sulfoxides and β- (dialkylamino) sulfones in high yields. The aminosulfoxidation reaction of aliphatic or aromatic aldehydes lacks diastereoselectivity, but the diastereomeric sulfoxides can be separated by HPLC or column chromatography for further use
  6. Keywords:
  7. Lithium perchlorate ; Mannich type reaction ; β-Amino sulfones ; β-Amino sulfoxides
  8. Source: European Journal of Organic Chemistry ; Issue 9 , 2000 , Pages 1735-1739 ; 1434193X (ISSN)
  9. URL: https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291099-0690%28200005%292000%3A9%3C1735%3A%3AAID-EJOC1735%3E3.0.CO%3B2-A