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The LiClO4-mediated synthesis of β-(dialkylamino) sulfoxides and β- (dialkylamino) sulfones by addition of α-lithiated salts of sulfoxides and sulfones to aldehydes and (trimethylsilyl)dialkylamines
Naimi Jamal, M. R ; Sharif University of Technology | 2000
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- Type of Document: Article
- DOI: 10.1002/(SICI)1099-0690(200005)2000:9<1735::AID-EJOC1735>3.0.CO;2-A
- Publisher: Wiley-VCH Verlag , 2000
- Abstract:
- The LiClO4-mediated one-pot reaction of aldehydes with (trimethylsilyl)dialkyl amines and the lithium salt of sulfoxides or sulfones, affords the corresponding β-(dialkylamino) sulfoxides and β- (dialkylamino) sulfones in high yields. The aminosulfoxidation reaction of aliphatic or aromatic aldehydes lacks diastereoselectivity, but the diastereomeric sulfoxides can be separated by HPLC or column chromatography for further use
- Keywords:
- Lithium perchlorate ; Mannich type reaction ; β-Amino sulfones ; β-Amino sulfoxides
- Source: European Journal of Organic Chemistry ; Issue 9 , 2000 , Pages 1735-1739 ; 1434193X (ISSN)
- URL: https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291099-0690%28200005%292000%3A9%3C1735%3A%3AAID-EJOC1735%3E3.0.CO%3B2-A