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Surface Modification of Metallic Implants and Improvement of their Biological Properties in Presence of Bioactive Ceramic Nanoparticles

Riahi, Zohreh | 2015

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  1. Type of Document: M.Sc. Thesis
  2. Language: Farsi
  3. Document No: 48057 (07)
  4. University: Sharif University of Technology
  5. Department: Materials Science and Engineering
  6. Advisor(s): Sadrnezhad, Khatiboleslam
  7. Abstract:
  8. By consideration of increasing demands to use implants and efforts to get technical knowledge and localization of this implants, considerable research in this field is needed. Therefore, presentation of a coating which is able to provide parameters needed for an acceptable implant is the aim of this study. In this direction, modification of surface of metallic implants in order to achieve nanotubes of titanium oxide, with the purpose of providing biocompatibility was done. On the other hand, because chronic infection of the implant’s surrounding is one of the main important reasons in rejection of implants, 〖TiO〗_2 nanotubes as a drug carrier were used in order to solve this problem. So, 〖TiO〗_2 nanotubes with different lengths were prepared and electrophoretic deposition of antibacterial Vancomycin with optimum concentration of 2 g⁄L and 10 V was performed. At final step, bioactive glass ceramic was used to provide bioactivity properties of designed coating and to reduce period of treatment. Therefore, electrophoretic deposition of a suspension which contained bioactive glass and drug was conducted at 10 V voltage and for 10 minutes. Drug release from the above mentioned coatings was investigated and it was showed that with increasing the length of nanotubes, not only the amount of loaded drug was increased but also the duration of drug release continued for a longer time (28 days). Images of Scanning Electron Microscopy showed that anodizing time of 80 minutes will results in creation of a surface with regular and homogeneous morphology for 〖TiO〗_2 nanotubes and according to results of drug release, this time ensures controlled release. Results of antibacterial test showed that the nature of drug does not change during loading. Bioactivity test results showed acceleration of hydroxyapatite creation on the surface of bioactive glass coated specimen. Finally, atomic force microscopy and contact angle measurement were used in order to investigate roughness and wettability of the surface. These tests showed that roughness and wetting of surfaces have increased that this is in complete consistency with improving absorption, cell adhesion and proliferation
  9. Keywords:
  10. Anodizing ; Bioactive Glass ; Titanium Oxide Nanotube ; Titanium Dioxide ; Vancomycin Antibiotic ; Electrophoretic Deposition

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