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- Type of Document: M.Sc. Thesis
- Language: English
- Document No: 45334 (56)
- University: Sharif University of Technology, International Campus, Kish Island
- Department: Science and Engineering
- Advisor(s): Akhavan, Omid
- Abstract:
- Graphene nanogrids fabricated by graphene nanoribbons obtained through oxidative unzipping of multi-walled carbon nanotubes, used as two-dimensional selective templates for accelerated differentiation of human mesenchymal stem cells (hMSCs), isolated from umbilical cord blood, into osteogenic lineage. The biocompatible and hydrophilic graphene nanogrids showed high actin cytoskeleton proliferations that coinciding with patterns of the nanogrids. The amounts of proliferations found are slightly better than proliferation on hydrophilic graphene oxide (GO) sheets, and significantly higher than non-uniform proliferations on hydrophobic reduced graphene oxide (rGO) sheets and polydimethylsiloxane substrate. In the presence of chemical inducers, the reduced graphene oxide nanoribbon (rGONR) grid showed a highly accelerated osteogenic differentiation of the hMSCs (a patterned differentiation) in short time of 7 days in which the amount of the osteogenesis was ~2.2 folds greater than the differentiation (a uniform differentiation) on the rGO sheets. We found that although in the absence of any chemical inducers the graphene nanogrids displayed slight patterned osteogenic differentiations, the graphene sheets could not present any differentiation. Therefore, the highly accelerated differentiation on the rGONR grid was allocated to both its excellent capability in adsorption of the chemical inducers and physical stresses induced by the surface topographic features of the nanogrids
- Keywords:
- Synthesis ; Graphine ; Stem Cell
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