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tumor-embolism
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Design and parameter study of integrated microfluidic platform for CTC isolation and enquiry; a numerical approach
, Article Biosensors ; Volume 8, Issue 2 , 18 June , 2018 ; 20796374 (ISSN) ; Ahmad, S ; Momeni, M ; Sharif University of Technology
2018
Abstract
Being the second cause of mortality across the globe, there is now a persistent effort to establish new cancer medication and therapies. Any accomplishment in treating cancers entails the existence of accurate identification systems empowering the early diagnosis. Recent studies indicate CTCs’ potential in cancer prognosis as well as therapy monitoring. The chief shortcoming with CTCs is that they are exceedingly rare cells in their clinically relevant concentration. Here, we simulated a microfluidic construct devised for immunomagnetic separation of the particles of interest from the background cells. This separation unit is integrated with a mixer subunit. The mixer is envisioned for...
A new insight to deformability correlation of circulating tumor cells with metastatic behavior by application of a new deformability-based microfluidic chip
, Article Analytica Chimica Acta ; Volume 1186 , 2021 ; 00032670 (ISSN) ; Khorasheh, F ; Alemzadeh, I ; Vossoughi, M ; Sharif University of Technology
Elsevier B.V
2021
Abstract
Isolation and characterization of circulating tumor cells (CTCs) found in blood samples of cancer patients have been considered as a reliable source for cancer prognosis and diagnosis. A new continuous microfluidic platform has been designed in this investigation for simultaneous capture and characterization of CTCs based on their deformability. The deformability-based chip (D-Chip) consists of two sections of separation and characterization where slanted weirs with a gap of 7 μm were considered. Although sometimes CTCs and leukocytes have the same size, the deformability differs in such a way that can be exploited for enrichment purposes. MCF7 and MDA-MB-231 cell lines were used for the...