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thymoquinone
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Theoretical and Experimental Simulation of Hepatic Cells and their Functionalities On-a-chip
, Ph.D. Dissertation Sharif University of Technology ; Firoozabadi, Bahar (Supervisor) ; Firoozbakhsh, Keikhosrow (Supervisor)
Abstract
Liver is the largest internal organ of the human body which serves many vital functionalities. Recently, liver-on-a-chip systems have been used to model some of the vital liver specific-functions and to investigate its related diseases. The purpose of the present study was simulation of some of these liver specific functionalities on-a-chip and using the obtained results in predicting hepatocellular functionalities i.e. production of some metabolites and modeling some of the liver-related diseases which have been done numerically and experimentally. Numerical simulations have been developed in two-dimensional and three-dimensional forms. In the 2D simulation, the governing equations i.e....
A hepatocellular carcinoma–bone metastasis-on-a-chip model for studying thymoquinone-loaded anticancer nanoparticles
, Article Bio-Design and Manufacturing ; Volume 3, Issue 3 , 2020 , Pages 189-202 ; Yesil Celiktas, O ; Kazan, A ; Maharjan, S ; Saghazadeh, S ; Firoozbakhsh, K ; Firoozabadi, B ; Zhang, Y. S ; Sharif University of Technology
Springer
2020
Abstract
We report the development of a metastasis-on-a-chip platform to model and track hepatocellular carcinoma (HCC)–bone metastasis and to analyze the inhibitory effect of an herb-based compound, thymoquinone (TQ), in hindering the migration of liver cancer cells into the bone compartment. The bioreactor consisted of two chambers, one accommodating encapsulated HepG2 cells and one bone-mimetic niche containing hydroxyapatite (HAp). Above these chambers, a microporous membrane was placed to resemble the vascular barrier, where medium was circulated over the membrane. It was observed that the liver cancer cells proliferated inside the tumor microtissue and disseminated from the HCC chamber to the...