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    Effects of severe plastic deformation on pre-osteoblast cell behavior and proliferation on AISI 304 and Ti-6Al-4V metallic substrates

    , Article Surface and Coatings Technology ; Volume 366 , 2019 , Pages 204-213 ; 02578972 (ISSN) Tevlek, A ; Aydın, H. M ; Maleki, E ; Varol, R ; Unal, O ; Sharif University of Technology
    Elsevier B.V  2019
    Abstract
    In this study, titanium alloy (Ti-6Al-4V) and austenitic stainless steel (AISI 304) biomedical alloys were subjected to surface severe plastic deformation (SSPD) via severe shot peening (SSP) with the conditions of A28-30 Almen intensity. SSP is widely accepted as much more effective than the conventional surface modification techniques since it forms a nano-grain layer with large number of dislocations and grain boundaries. The SSP treatment in this study was led to a very thin rough layer in Ti-6Al-4V titanium alloy compared to that of AISI 304. The thicker layer of AISI 304 was created by twin-twin intersections and a martensite structure transformations. SSP treatment was resulted in a... 

    CaTiO3/α-TCP coatings on CP-Ti prepared via electrospinning and pulsed laser treatment for in-vitro bone tissue engineering

    , Article Surface and Coatings Technology ; Volume 401 , 2020 Yadi, M ; Esfahani, H ; Sheikhi, M ; Mohammadi, M ; Sharif University of Technology
    Elsevier B.V  2020
    Abstract
    In this study, the in-vitro bone regeneration ability of commercial pure titanium (CP-Ti) surface modified via electrospun polyvinylidene/hydroxyapatite (PVP/HA) masking and subsequent Nd-YAG pulsed laser treatment was investigated. The ratio of HA to PVP played a significant role in achieving a perfect homogenous mask on the CP-Ti. In the laser treatment process, the parameter of area scanning speed (ASS) had an important influence on the final surface morphology. A favorable range was defined for this parameter where these two conditions were satisfied: no PVP remaining and no severe substrate melting. Within a favorable range of ASS, as decreasing ASS exchanged the surface structure from... 

    Recent advances in the modification of carbon-based quantum dots for biomedical applications

    , Article Materials Science and Engineering C ; Volume 120 , 2021 ; 09284931 (ISSN) Alaghmandfard, A ; Sedighi, O ; Tabatabaei Rezaei, N ; Abedini, A. A ; Malek Khachatourian, A ; Toprak, M. S ; Seifalian, A ; Sharif University of Technology
    Elsevier Ltd  2021
    Abstract
    Carbon-based quantum dots (CDs) are mainly divided into two sub-groups; carbon quantum dots (CQDs) and graphene quantum dots (GQDs), which exhibit outstanding photoluminescence (PL) properties, low toxicity, superior biocompatibility and facile functionalization. Regarding these features, they have been promising candidates for biomedical science and engineering applications. In this work, we reviewed the efforts made to modify these zero-dimensional nano-materials to obtain the best properties for bio-imaging, drug and gene delivery, cancer therapy, and bio-sensor applications. Five main surface modification techniques with outstanding results are investigated, including doping, surface... 

    Recent advances in the modification of carbon-based quantum dots for biomedical applications

    , Article Materials Science and Engineering C ; Volume 120 , 2021 ; 09284931 (ISSN) Alaghmandfard, A ; Sedighi, O ; Tabatabaei Rezaei, N ; Abedini, A. A ; Malek Khachatourian, A ; Toprak, M. S ; Seifalian, A ; Sharif University of Technology
    Elsevier Ltd  2021
    Abstract
    Carbon-based quantum dots (CDs) are mainly divided into two sub-groups; carbon quantum dots (CQDs) and graphene quantum dots (GQDs), which exhibit outstanding photoluminescence (PL) properties, low toxicity, superior biocompatibility and facile functionalization. Regarding these features, they have been promising candidates for biomedical science and engineering applications. In this work, we reviewed the efforts made to modify these zero-dimensional nano-materials to obtain the best properties for bio-imaging, drug and gene delivery, cancer therapy, and bio-sensor applications. Five main surface modification techniques with outstanding results are investigated, including doping, surface...