Sharif Digital Repository

Simulating the in-vivo environment of cancer tumors outside the body, can provide an appropriate condition for studying different key processes of the tumor micro-environment, such as aggregation, formation, growth, angiogenesis and metastasis of the cancer tumor cells, which can be useful in finding methods to cure, or at least control cancer. Every year, a variety of drugs are being developed to overcome cancer, all of which need to be experimented. Although, these drugs are now experimented on animals, and some human volunteers, the reaction of different patients’ cancer cells to different drugs may differ with the experimented animals, or even with other people. So, there needs to be a... 

In this project the effect of rolling temperature on mechanical properties and microstructure evolution of a low carbon steel was studied. The steel was rolled up to a nominal strain of 67% at three different temperatures consisted of room, blue brittleness, and subzero temperature. Micreohardnessand tensile tests were used to characterize the recrystallization kinetics. Optical and scanning electron microscopic examinations were carried out to evaluate the mechanical, grain size, and the kinetics of static recrystallization by the Avrami equation. The results indicated that the volume fraction of static recrystallization increases with the increase in annealing period. The Avrami exponent... 

Despite the extensive research conducted so far to treat cancer, this disease is still one of the main causes of death worldwide. The results of recent studies reveal the importance of the tumor microenvironment in the growth, proliferation, and invasion of the primary tumor. Most common models in cancer research, such as 2-dimensional in vitro models and xenografts, do not have sufficient ability to mimic the interaction of tumors with human stromal tissue. Therefore, the implementation of 3-dimensional in vitro models with the ability to replicate tumor microenvironments is essential. In this study, a microfluidic platform has been introduced to create parallel models of the tumor... 

In this research, using the crystal plasticity finite element method, the effects of various microstructural features on behavior of spherical steel sheets have been investigated. The cementite phase ratio, the grain sizes of ferrite and cementite, and the percentage of residual pearlite in the steel structure due to incomplete annealing are the major microstructural parameters studied in this work. A grain generator software has been developed to generate ferrite grains as well as cementite particles distributed in the ferrite matrix. A hard coating with special properties as an intermediate layer around the cementite grains has been considered to simulate the contact between ferrite grains... 

Nowadays, we are witnesses of deaths caused by cancer in large statistical amounts. Vast number of investigations are conducted for anticancer drug evaluation on human and animal cells using traditional two-dimensional and three-dimensional culturing platforms. However, most of them are not successful due to the lack of in-vivo relevant microenvironment in these platforms. One of the best cancer in-vitro cultures is the tumor spheroid which is a spherical cellular aggregation. By culturing these tumor spheroids in a microfluidic chip, it is possible to mimic the in-vivo microenvironment elements such as nutrient and metabolite gradients. Here we present a microfluidic device fabricated using... 

Nowadays, advanced and inexpensive pre-clinical methods for investigating the effects of anti-cancer drugs are expanding. One of the latest three-dimensional laboratory modeling for evaluating the effects of drugs is the use of tumor-on-chip technology, which actually models the physiological system of the body through three-dimensional scaffolds, multicellular cultures, and shaped vascular systems. In this study, three-dimensional culture of cancer cells was performed in the form of spheroids. A chip of U-shaped microstructures with and without gaps was used to trap cells and form cancer spheroids. We simulated the simultaneous effect of drug and oxygen concentration distribution inside the...