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Seizures are defined as manifest of excessive and hypersynchronous activity of neurons in the cerebral cortex and represent a frequent malfunction of the human central nervous system. Therefore, the search for precursors and predictors of a seizure is of utmost clinical relevance and may even guide us to a deep understanding of the seizure generating mechanisms. In this study we analyzed invasive electroencephalogram (EEG) recordings in rats with experimentally induced generalized epilepsy with a nonlinear method called, dissimilarity index. In order to predict epileptic seizures automatically, Bhattacharyya distance between trajectory matrix of reference window, during an interval quite... 

Detection of seizure periods in an epileptic patient is an important part of health care. However, due to the variety in types of seizures and location of them, real-time seizure detection is not straight forward. In this paper, we propose a method for seizure detection from EEG signals in datasets which have both generalized and focal seizures. The proposed method is useful in the situations that we have no prior knowledge about the location of the patient's seizure and the pattern of evolution of seizure location. In the proposed method, first, the artifacts are automatically reduced by Blind Source Separation (BSS) methods. Then, the channels are clustered into two clusters. After that,... 

Epileptic seizures are generated by an abnormal synchronization of neurons. Since epileptic seizures are unforeseeable for the patients, epileptic seizures detection is an interesting issue in epileptology, that novel approaches to understand the mechanism of epileptic seizures. In this study we analyzed invasive electroencephalogram (EEG) recordings in patients suffering from medically intractable focal epilepsy with a nonlinear method called, dissimilarity index. In order to detect epileptic seizures Bhattacharyya distance between trajectory matrix of reference window during an interval quite distant in time from any seizure and trajectory matrix of present window is employed to measure... 

Clinical data from epileptic patients reveal important information about the characteristics of the particular type of epilepsy. Such data is often acquired in a bimodal fashion, e.g. video recordings are collected with the standard Electroencephalogram (EEG) data, in order to help the specialists validate their assessment based on one modality with the other. Manual annotation of the onset of seizures across several days' worth of data is time consuming. This paper proposes an automated epilepsy seizure detection method based on a combination of features from EEG and video data, and compares it against detectors using either modality alone. © 2017 IEEE  

The electroencephalogram (EEG) is a representative signal containing information about the condition of the brain. The shape of the wave may contain useful information about its state. However, the human observer cannot directly monitor these subtle details. Besides, since bio-signals are highly subjective, the symptoms may appear at random in the time scale. Therefore, the EEG signal parameters, extracted and analyzed using computers, are highly useful in diagnosis. The aim of this work is to compare the different classifiers when applied to EEG data from normal and epileptic subjects. For this purpose an adaptive neural fuzzy network (ANFN) to classify normal and epileptic EEG signals is... 

Introduction: Temporal lobe epilepsy (TLE) is the most common and drug resistant epilepsy in adults. Due to behavioral, morphologic and electrographic similarities, pilocarpine model of epilepsy best resembles TLE. This study was aimed at determination of the changes in electroencephalogram (EEG) sub-bands amplitude during focal seizures in the pilocarpine model of epilepsy. Analysis of these changes might help detection of a pre-seizure state before an oncoming seizure. Methods: Rats were treated by scopolamine (1mg/kg, s.c) to prevent cholinergic effects. After 30 min, pilocarpine (380 mg/kg, i.p) was administered to induce status epilepticus (SE) and 2 hours after SE, diazepam (20 mg/kg,... 

Objective: Epileptic seizure detection is a key step for epilepsy assessment. In this work, using the pentylenetetrazole (PTZ) model, seizures were induced in rats, and ECoG signals in interictal, preictal, ictal, and postictal periods were recorded. The recorded ECoG signals were then analyzed to detect epileptic seizures in the epileptic rats. Methods: Two different approaches were considered in this work: thresholding and classification. In the thresholding approach, a feature is calculated in consecutive windows, and the resulted index is tracked over time and compared with a threshold. The moment the index crosses the threshold is considered as the moment of seizure onset. In the... 

Objective Psychogenic non-epileptic seizures (PNES) are paroxysmal events that, in contrast to epileptic seizures, are related to psychological causes without the presence of epileptiform EEG changes. Recent models suggest a multifactorial basis for PNES. A potentially paramount, but currently poorly understood factor is the interplay between psychiatric features and a specific vulnerability of the brain leading to a clinical picture that resembles epilepsy. Hypothesising that functional cerebral network abnormalities may predispose to the clinical phenotype, the authors undertook a characterisation of the functional connectivity in PNES patients. Methods The authors analysed the whole-head... 

Objective(s): Seizure detection during online recording of electrophysiological parameters is very important in epileptic patients. In the present study, online analysis of field potential recordings was used for detecting spontaneous seizures in epileptic animals. Materials and Methods: Epilepsy was induced in rats by pilocarpine injection. During the chronic period of the pilocarpine model, local field potential (LFP) recording was run for at least 24 hr. At the same time, video monitoring of the animals was done to determine the real time of seizure occurrence. Both power and sample entropy of LFP were used for online analysis. Results: Obtained results showed that changes in LFP power... 

Epilepsy is the most common disorder of human brain. The goal of this paper is to present a new method for classification of epileptic phases based on the sub-bands of electroencephalogram (EEG) signals obtained from the Stockwell transform (ST). ST is a time-frequency analysis that not only covers the advantages of both short-time Fourier transform (FT) and wavelet transform (WT), but also overcomes their shortcomings. In the proposed method, at first, EEG signal is transformed into time-frequency domain using ST and all operations are performed in the new domain. Then, the amplitudes of ST in five sub-bands, namely delta (δ), theta (θ), alpha (α), beta (β), and gamma (γ), are computed. In... 

This paper presents a scalp electroencephalogram (EEG) rhythmic pattern detection scheme based on neural networks. Rhythmic discharges detection is applicable to the majority of seizures seen in newborns, and is listed as detecting 90% of all the seizures. In this approach some features based on various methods are extracted and compared by a modified multilayer neural network in order to find rhythmic discharges. Statistical performance comparison with seizure detection schemes of Gotman et al. and Liu et al. is performed. © 2006 IEEE  

In this paper, the performance of traditional variance-based method for detection of epileptic seizures in EEG signals are compared with various methods based on nonlinear time series analysis, entropies, logistic regression, discrete wavelet transform and time frequency distributions. We noted that variance-based method in compare to the mentioned methods had the best result (100%) applied on the same database. © 2006 IEEE  

The aim of this work is to introduce a new method based on time frequency distribution for classifying the EEG signals. Some parameters are extracted using time-frequency distribution as inputs to a feed-forward backpropagation neural networks (FBNN). The proposed method had better results with 98.25% accuracy compared to previously studied methods such as wavelet transform, entropy, logistic regression and Lyapunov exponent  

Blind source separation is an important field of study in signal processing, in which the goal is to estimate source signals by having mixed observations. There are some conventional methods in this field that aim to estimate source signals by considering certain assumptions on sources. One of the most popular assumptions is the non-Gaussianity of sources which is the basis of many popular blind source separation methods. These methods may fail to estimate sources when the distribution of two or more sources is Gaussian. Hence, this study aims to introduce a new approach in blind source separation for nonlinear and chaotic signals by using a dynamical similarity measure and relaxing... 

Removing muscle activity from ictal ElectroEncephaloGram (EEG) data is an essential preprocessing step in diagnosis and study of epileptic disorders. Indeed, at the very beginning of seizures, ictal EEG has a low amplitude and its morphology in the time domain is quite similar to muscular activity. Contrary to the time domain, ictal signals have specific characteristics in the time-frequency domain. In this paper, we use the time-frequency signature of ictal discharges as a priori information on the sources of interest. To extract the time-frequency signature of ictal sources, we use the Canonical Correlation Analysis (CCA) method. Then, we propose two time-frequency based semi-blind source...