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Constitutive Modeling and Numerical Simulation of Coronary Arteries Mechanical Behavior in Stenting and Succeeding Growth
, Ph.D. Dissertation Sharif University of Technology ; Naghdabadi, Reza (Supervisor) ; Sohrabpour, Saeed (Supervisor)
Abstract
Cardiovascular diseases are the major cause of death worldwide. Atherosclerosis is one of the major types of cardiovascular diseases in which fibrous and fatty materials, called plaque, build up inside the artery and cause partial or total occlusion of the artery. Intravascular balloon angioplasty with or without stenting is the most common treatment of this disease. In 2010, approximately 954000 stent implantations were performed in the United States. The major issue associated with stenting is reclosure or renarrowing of the transverse section of the artery termed in-stent restenosis (ISR). Unfortunately, nearly one–third of the patients
who receive stent implantation require further...
who receive stent implantation require further...
Influence of Geometrical Parameters on Hemodynamics of Blood Flow in Coronary Artery Bypass Graft by FSI Numerical Method
, M.Sc. Thesis Sharif University of Technology ; Halali, Mohammad (Supervisor) ; Hossein Ahmadi, Zargham (Supervisor)
Abstract
In this study, the simulation of blood flow through a stenosed coronary artery and a bypass graft are discussed using fluid-structure interaction numerical method. Effects of the geometrical parameters of CABG surgery on hemodynamics have been studied. Investigated hemodynamic variables include shear stress on the vessel wall, the velocity profile in high-risk areas and the pathlines. Lower than 0.5 Pa shear stress on intimal layer of arteries causes the formation of plaque on the wall. Angle of 30 degrees and diameter ratio of bypass to host artery of 1:1 are proposed as the optimum geometry. The distance of the anastomosis from the site of occlusion has no effect on surgery. Also,...
A Mechanobiological model for damage-induced growth in arterial tissue with application to in-stent restenosis
, Article Journal of the Mechanics and Physics of Solids ; Volume 101 , 2017 , Pages 311-327 ; 00225096 (ISSN) ; Naghdabadi, R ; Sohrabpour, S ; Holzapfel, G. A ; Sharif University of Technology
Elsevier Ltd
2017
Abstract
In-stent restenosis (ISR) is one of the main drawbacks of stent implementation which limits the long-term success of the procedure. Morphological changes occurring within the arterial wall due to stent-induced mechanical injury are a major cause for activation of vascular smooth muscle cells (VSMCs), and the subsequent development of ISR. Considering the theory of volumetric mass growth and adopting a multiplicative decomposition of the deformation gradient into an elastic part and a growth part, we present a mechanobiological model for ISR. An evolution equation is developed for mass growth of the neointima, in which the activation of VSMCs due to stent-induced damage (injury) and the...
Nanotechnology in diagnosis and treatment of coronary artery disease
, Article Nanomedicine ; Volume 11, Issue 5 , 2016 , Pages 513-530 ; 17435889 (ISSN) ; Zare, H ; Bakhshian Nik, A ; Yazdani, N ; Hamrang, M ; Mohamed, E ; Sahandi Zangabad, P ; Moosavi Basri, S. M ; Bakhtiari, L ; Hamblin, M. R ; Sharif University of Technology
Future Medicine Ltd
Abstract
Nanotechnology could provide a new complementary approach to treat coronary artery disease (CAD) which is now one of the biggest killers in the Western world. The course of events, which leads to atherosclerosis and CAD, involves many biological factors and cellular disease processes which may be mitigated by therapeutic methods enhanced by nanotechnology. Nanoparticles can provide a variety of delivery systems for cargoes such as drugs and genes that can address many problems within the arteries. In order to improve the performance of current stents, nanotechnology provides different nanomaterial coatings, in addition to controlled-release nanocarriers, to prevent in-stent restenosis....
Recent progress in inorganic and composite coatings with bactericidal capability for orthopaedic applications
, Article Nanomedicine: Nanotechnology, Biology, and Medicine ; Volume 7, Issue 1 , Feb , 2011 , Pages 22-39 ; 15499634 (ISSN) ; Tamjid, E ; Pishbin, F ; Boccaccini, A. R ; Sharif University of Technology
Abstract
This review covers the most recent developments of inorganic and organic-inorganic composite coatings for orthopedic implants, providing the interface with living tissue and with potential for drug delivery to combat infections. Conventional systemic delivery of drugs is an inefficient procedure that may cause toxicity and may require a patient's hospitalization for monitoring. Local delivery of antibiotics and other bioactive molecules maximizes their effect where they are required, reduces potential systemic toxicity and increases timeliness and cost efficiency. In addition, local delivery has broad applications in combating infection-related diseases. Polymeric coatings may present some...