Sharif Digital Repository

Fontan operation is a final palliative surgical treatment for patients with a single ventricle (SV) physiology. One of the common disadvantages of Fontan operation is to generate a non-pulsatile flow instead of the normal pulsatile flow produced by contraction of the ventricle. Theoretically, in SV patients, maintaining the antegrade flow through pulmonary valve can produce flow pulsatility in the right and left pulmonary arteries. However, it not only increases the energy loss in the Fontan of total cavopulmonary pathway (TCPC), but also imposes an extra load on pulmonary arteries as well as the ventricle. In this study, the potential capability of pulmonary valve of the patient that can be... 

The Fontan surgery is performed on patients with a single ventricle heart defect to prevent the combination of highlyoxygenated and poorly-oxygenated blood. Blood flow in total cavopulmonary connection (TCPC) which culminates an ordinary Fontan operation is practically steady-state but this flow is not appropriate for respiratory systems. This article investigates an approach in Fontan surgery that has been recently proposed in order to make the pulmonary blood flow pulsating. Moreover, for investigating the compliance of vessels and its effects on blood flow in TCPC, we have used the FSI (Fluid Structure Interaction) method as well as rigid wall assumption for comparison purposes. Our TCPC... 

Single-ventricle anomaly is a hereditary heart disease that is characterized by anatomical malformations. The main consequence of this malformation is desaturated blood flow, which without proper treatment increases the risk of death. The classical treatment is based on a three-stage palliative procedure which should begin from the first few days of patient’s life. The final stage is known as Fontan procedure, in which inferior vena cava is directly connected to pulmonary arteries without going through the ventricle. This connection is called total cavopulmonary connection (TCPC). After surgery, the single ventricle supplies adequate and saturated systemic blood flow to the body; however,... 

Purpose: Cardiac multimodal image fusion can offer an image with various types of information in a single image. Many coronary stenosis, which are anatomically clear, are not functionally significant. The treatment of such kind of stenosis can cause irreversible effects on the patient. Thus, choosing the best treatment planning depend on anatomical and functional information is very beneficial. Methods: An algorithm for the fusion of coronary computed tomography angiography (CCTA) as an anatomical and transthoracic echocardiography (TTE) as a functional modality is presented. CCTA and TTE are temporally registered using manifold learning. A pattern search optimization algorithm, using...