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Glypican-1 overexpression in different types of breast cancers
, Article OncoTargets and Therapy ; Volume 14 , 2021 , Pages 4309-4318 ; 11786930 (ISSN) ; Al Saraireh, Y. M ; Youssef, A. M. M ; Al Sarayra, Y. M ; Alrawashdeh, H. M ; Sharif University of Technology
Dove Medical Press Ltd
2021
Abstract
Purpose: Treatment of metastatic breast cancer patients is challenging and remains a major underlying cause of female mortality. Understanding molecular alterations in tumor development is critical to identify novel biomarkers and targets for cancer diagnosis and therapy. One of the aberrant cancer expressions gaining recent research interest is glypican-1. Several studies reported strong glypican-1 expression in various types of human cancers. However, none of these investigated glypican-1 expression in a large cohort of breast cancer histopathological subtypes. Patients and Methods: Immunohistochemistry was used to assess glypican-1 expression in 220 breast cancer patients and its relation...
Opposite trends of GAS6 and GAS6-AS expressions in breast cancer tissues
, Article Experimental and Molecular Pathology ; Volume 118 , 2021 ; 00144800 (ISSN) ; Hussen, B. M ; Taheri, F ; Sattari, A ; Yousefi, H ; Omrani, M. D ; Nazer, N ; Ghafouri Fard, S ; Taheri, M ; Sharif University of Technology
Academic Press Inc
2021
Abstract
Growth arrest-specific gene 6 (GAS6) is a growth factor-like cytokine whose function is related with vitamin K. This protein interacts with receptor tyrosine kinase proteins such as Tyro3, Axl, and TAM Receptor family, therefore affecting the tumorigenic processes via different mechanisms. GAS6-antisense 1 (GAS6-AS1) is a long non-coding RNAs (lncRNAs) that is transcribed from a genomic regions nearby GAS6. This lncRNA is also implicated in the pathobiology of cancer. We intended to judge the role of GAS6 and GAS6-AS1 in the pathogenesis of breast cancer through appraisal of their expression levels in breast cancer tissues and their paired neighboring non-cancerous samples. Expression of...