Sharif Digital Repository

A hybrid scaffold of gelatin-glycosaminoglycan matrix and fibrin (FGG) has been synthesized to improve the mechanical properties, degradation time and cell response of fibrin-like scaffolds. The FGG scaffold was fabricated by optimizing some properties of fibrin-only gel and gelatin-glycosaminoglycan (GG) scaffolds. Mechanical analysis of optimized fibrin-only gel showed the Young module and tensile strength of up to 72 and 121 KPa, respectively. Significantly, the nine-fold increase in the Young modulus and a seven-fold increase in tensile strength was observed when fibrin reinforced with GG scaffold. Additionally, the results demonstrated that the degradation time of fibrin was enhanced... 

Capillary continuity between adjacent matrix blocks through formation of liquid bridge controls the recovery factor of gravity drainage process in fractured reservoirs. However, stability of liquid bridges as well as related capillary pressure in horizontal rough fractures is not well discussed in the available literature. In this work, new models of rough-walled fracture are developed and the role of roughness size and frequency on formation of liquid bridge and fracture capillary pressure are investigated. The Young-Laplace equation is numerically solved to characterize the liquid bridge formed in the proposed models of rough fractures. Critical fracture aperture for a range of liquid...