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Mathematical modeling of drug release from biodegradable polymeric microneedles
, Article Bio-Design and Manufacturing ; Volume 2, Issue 2 , 2019 , Pages 96-107 ; 20965524 (ISSN) ; Rabiee, M ; Rafizadeh, M ; Rabiee, N ; Shamsabadi, A. S ; Bagherzadeh, M ; Salarian, R ; Tahriri, M ; Tayebi, L ; Sharif University of Technology
Springer
2019
Abstract
Transdermal drug delivery systems have overcome many limitations of other drug administration routes, such as injection pain and first-pass metabolism following oral route, although transdermal drug delivery systems are limited to drugs with low molecular weight. Hence, new emerging technology allowing high molecular weight drug delivery across the skin—known as ‘microneedles’—has been developed, which creates microchannels that facilitate drug delivery. In this report, drug-loaded degradable conic microneedles are modeled to characterize the degradation rate and drug release profile. Since a lot of data are available for polylactic acid-co-glycolic acid (PLGA) degradation in the literature,...
Biodegradable nanopolymers in cardiac tissue engineering: from concept towards nanomedicine
, Article International Journal of Nanomedicine ; Volume 15 , 2020 , Pages 4205-4224 ; Rabiee, N ; Hajebi, S ; Ahmadi, S ; Fatahi, Y ; Hosseini, M ; Bagherzadeh, M ; Ghadiri, A. M ; Rabiee, M ; Jajarmi, V ; Webster, T. J ; Sharif University of Technology
Dove Medical Press Ltd
2020
Abstract
Cardiovascular diseases are the number one cause of heart failure and death in the world, and the transplantation of the heart is an effective and viable choice for treatment despite presenting many disadvantages (most notably, transplant heart availability). To overcome this problem, cardiac tissue engineering is considered a promising approach by using implantable artificial blood vessels, injectable gels, and cardiac patches (to name a few) made from biodegradable polymers. Biodegradable polymers are classified into two main categories: natural and synthetic polymers. Natural biodegradable polymers have some distinct advantages such as biodegradability, abundant availability, and...
Synthesis of micelles based on chitosan functionalized with gold nanorods as a light sensitive drug delivery vehicle
, Article International Journal of Biological Macromolecules ; Volume 149 , 2020 , Pages 809-818 ; Bagherifard, M ; Doroudian, M ; Sharif University of Technology
Elsevier B.V
2020
Abstract
This study aims to design photo-triggered micelles by using a natural base polymer. Chitosan was functionalized with thiourea, and in the next step, it was modified by grafting poly(L-lactide), poly(N-isopropylacrylamide), and poly(acrylamide) in determined ratio to form thermo-sensitive micelles. The sulfur content of chitosan@thiourea was measured about 2%. Grafting of polymers on chitosan was characterized by FT-IR and NMR techniques. The critical micellar concentration was measured by using photo luminescence spectroscopy. The size and surface morphology experiments revealed that average size of micelles is about 14 nm, and the length and width of GNRs are about 65 and 19 nm,...
PLGA/TiO2 nanocomposite scaffolds for biomedical applications: Fabrication, photocatalytic, and antibacterial properties
, Article BioImpacts ; Volume 11, Issue 1 , 2021 , Pages 45-52 ; 22285652 (ISSN) ; Madaah Hosseini, H. R ; Nokhbedehghan, Z ; Samadikuchaksaraei, A ; Sharif University of Technology
Tabriz University of Medical Sciences
2021
Abstract
Introduction: Porous 3D scaffolds synthesized using biocompatible and biodegradable materials could provide suitable microenvironment and mechanical support for optimal cell growth and function. The effect of the scaffold porosity on the mechanical properties, as well as the TiO2 nanoparticles addition on the bioactivity, antimicrobial, photocatalytic, and cytotoxicity properties of scaffolds were investigated. Methods: In the present study, porous scaffolds consisting poly (lactide-co-glycolide) (PLGA) containing TiO2 nanoparticles were fabricated via air-liquid foaming technique, which is a novel method and has more advantages due to not using additives for nucleation compared to former...
Polymeric nanoparticles for nasal drug delivery to the brain: relevance to alzheimer's disease
, Article Advanced Therapeutics ; Volume 4, Issue 3 , 2021 ; 23663987 (ISSN) ; Ahmadi, S ; Afshari, R ; Khalaji, S ; Rabiee, M ; Bagherzadeh, M ; Fatahi, Y ; Dinarvand, R ; Tahriri, M ; Tayebi, L ; Hamblin, M. R ; Webster, T. J ; Sharif University of Technology
Blackwell Publishing Ltd
2021
Abstract
Currently, Alzheimer's disease (AD) accounts for more than half of all dementia cases. Although genetics, age, and environmental factors affect the disease, the cause of AD is not yet fully known. Various drugs have been proposed for the prevention and treatment of AD, but the delivery of these therapeutic agents to the brain is difficult. The blood–brain barrier prevents systemic drugs from accessing the central nervous system and designing a suitable system to overcome this barrier has attracted much attention. The intranasal pathway, given its proximity to the brain, provides a great opportunity for drug delivery. Understanding the physiological characteristics of the nose can be useful...
Advances in skin regeneration: application of electrospun scaffolds
, Article Advanced Healthcare Materials ; Volume 4, Issue 8 , 2015 , Pages 1114-1133 ; 21922640 (ISSN) ; Boroujeni, S. M ; Omidvarkordshouli, N ; Soleimani, M ; Sharif University of Technology
Wiley-VCH Verlag
2015
Abstract
The paucity of cellular and molecular signals essential for normal wound healing makes severe dermatological ulcers stubborn to heal. The novel strategies of skin regenerative treatments are focused on the development of biologically responsive scaffolds accompanied by cells and multiple biomolecules resembling structural and biochemical cues of the natural extracellular matrix (ECM). Electrospun nanofibrous scaffolds provide similar architecture to the ECM leading to enhancement of cell adhesion, proliferation, migration and neo tissue formation. This Review surveys the application of biocompatible natural, synthetic and composite polymers to fabricate electrospun scaffolds as skin...
Inorganic nanomaterials for chemo/photothermal therapy: a promising horizon on effective cancer treatment
, Article Biophysical Reviews ; Volume 11, Issue 3 , 2019 , Pages 335-352 ; 18672450 (ISSN) ; Zamani, M ; Golizadeh, M ; Bavi, O ; Sharif University of Technology
Springer Verlag
2019
Abstract
During the last few decades, nanotechnology has established many essential applications in the biomedical field and in particular for cancer therapy. Not only can nanodelivery systems address the shortcomings of conventional chemotherapy such as limited stability, non-specific biodistribution and targeting, poor water solubility, low therapeutic indices, and severe toxic side effects, but some of them can also provide simultaneous combination of therapies and diagnostics. Among the various therapies, the combination of chemo- and photothermal therapy (CT-PTT) has demonstrated synergistic therapeutic efficacies with minimal side effects in several preclinical studies. In this regard,...
Burgeoning polymer nano blends for improved controlled drug release: A review
, Article International Journal of Nanomedicine ; Volume 15 , March , 2020 , Pages 4363-4392 ; Shahraki, B. T ; Rabiee, N ; Fatahi, Y ; Dinarvand, R ; Tavakolizadeh, M ; Ahmadi, S ; Rabiee, M ; Bagherzadeh, M ; Pourjavadi, A ; Farhadnejad, H ; Tahriri, M ; Webster, T. J ; Tayebi, L ; Sharif University of Technology
Dove Medical Press Ltd
2020
Abstract
With continual rapid developments in the biomedical field and understanding of the important mechanisms and pharmacokinetics of biological molecules, controlled drug delivery systems (CDDSs) have been at the forefront over conventional drug delivery systems. Over the past several years, scientists have placed boundless energy and time into exploiting a wide variety of excipients, particularly diverse polymers, both natural and synthetic. More recently, the development of nano polymer blends has achieved noteworthy attention due to their amazing properties, such as biocompatibility, biodegradability and more importantly, their pivotal role in controlled and sustained drug release in vitro and...
A novel pathway to produce biodegradable and bioactive PLGA/TiO2 nanocomposite scaffolds for tissue engineering: Air–liquid foaming
, Article Journal of Biomedical Materials Research - Part A ; Volume 108, Issue 6 , 2020 , Pages 1390-1407 ; Madaah Hosseini, H. R ; Samadikuchaksaraei, A ; Sharif University of Technology
John Wiley and Sons Inc
2020
Abstract
Poly (lactate-co-glycolate) (PLGA) is a typical biocompatible and biodegradable synthetic polymer. The addition of TiO2 nanoparticles has shown to improve compressive modulus of PLGA scaffolds and reduced fast degradation. A novel method has been applied to fabricate PLGA/TiO2 scaffolds without using any inorganic solvent, with aim of improving the biocompatibility, macroscale morphology, and well inter-connected pores efficacy: Air–Liquid Foaming. Field Emission Scanning Electron Microscopy (FESEM) revealed an increase in interconnected porosity of up to 98%. As well the compressive testing showed enhancement in modulus. Bioactivity and in vitro degradation were studied with immersion of...
Recent progress in inorganic and composite coatings with bactericidal capability for orthopaedic applications
, Article Nanomedicine: Nanotechnology, Biology, and Medicine ; Volume 7, Issue 1 , Feb , 2011 , Pages 22-39 ; 15499634 (ISSN) ; Tamjid, E ; Pishbin, F ; Boccaccini, A. R ; Sharif University of Technology
Abstract
This review covers the most recent developments of inorganic and organic-inorganic composite coatings for orthopedic implants, providing the interface with living tissue and with potential for drug delivery to combat infections. Conventional systemic delivery of drugs is an inefficient procedure that may cause toxicity and may require a patient's hospitalization for monitoring. Local delivery of antibiotics and other bioactive molecules maximizes their effect where they are required, reduces potential systemic toxicity and increases timeliness and cost efficiency. In addition, local delivery has broad applications in combating infection-related diseases. Polymeric coatings may present some...
Chemotherapeutic effects of Apigenin in breast cancer: Preclinical evidence and molecular mechanisms; enhanced bioavailability by nanoparticles
, Article Biotechnology Reports ; Volume 34 , 2022 ; 2215017X (ISSN) ; Zahmatkeshan, M ; Akbarzadeh, A ; Rabiee, N ; Ahmadi, S ; Keyhanvar, P ; Rezayat, S. M ; Seifalian, A. M ; Sharif University of Technology
Elsevier B.V
2022
Abstract
This review highlights using nanotechnology in increasing the bioavailability of AP (Apigenin) to enhance its therapeutic efficacy in breast cancer treatment. Breast cancer is one of the most leading causes of cancer death in women both in developed and developing countries. According to several epidemiological and clinical trial studies that indicate progestin-stimulated breast cancer in post-menopausal women; it is necessary to determine compounds to suppress or attenuate the tumor-promoting effects of progestins in breast cells. For this purpose, using the natural anti-progestins, including AP compared with the chemical ones could be significantly effective due to the lack of toxicities...