Sharif Digital Repository

Application of the advanced control techniques and information technology in the biomedical engineering have been the focal point of the research communities in biomedical engineering due to the rapid growth of the nonlinear control theories along with the computer hardware. In this work the application of differential geometry and globally linearizing control has been applied to efficiently control the first phase of HIV disease based on the HIV infection model proposed in the literature. All the efforts have been in the way to obtain a suitable scenario of drug administration to suppress and control the infection. In the proposed scenario, drug administration is time dependant and... 

As diseases of eye’s posterior segment has got widespread outbreak in the world, the selection of treatment is very important. Until now, intravitreal injecton has been the most common way of drug delivery to the posterior segment. Although this method is effective, halflife of some drugs in the vitreous cavity, especially those with low molecular weight, is just about some hours. Therefore, it is necessary to repeat injection in order to maintain drug concentration level of the posterior segment in the desired level. Intravitreal injection is invasive and may cause severe adverse effects such as vitreous hemorrhage, retinal detachment, endophthalmitis and cataract. In order to decrease the... 

The tumor is a collection of cells (cell mass) caused by the lack or ineffectiveness of cellular proliferation inhibitors. Many types of cancers are associated with the emergence of a tumor, a tissue with specific physiological characteristics. The tumors grow very fast so researchers try to prevent their growth and eventually destroy them. Thermal ablation by MWA(microwave ablation) is a common and minimally-invasive treatment for primary and secondary liver tumors that can not be cured by surgery. During treatment, the tissue is heated by microwaves and at a temperature higher than 50 degree Celsius, destroyed by thermal ablation. In this study, two thermal models have been used to... 

The purpose of this study is to propose a stable treatment strategy for hepatitis C infection by considering several practical limitations of the treatment and using control theories. First, hepatitis C disease and its transmission, diagnosis, and treatment methods have been introduced. Then, the mathematical models of hepatitis C dynamics in the body have been presented, and their ability in predicting the observed clinical behaviors of the patients has been studied. Thereafter, the extended versions of these models by considering pharmacokinetics/dynamics equations of the drugs have been proposed to have a more realistic mathematical model. After that, the practical features of the disease...