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partial-volume-effect
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Magnetite/dextran-functionalized graphene oxide nanosheets for in vivo positive contrast magnetic resonance imaging
, Article RSC Advances ; Volume 5, Issue 59 , May , 2015 , Pages 47529-47537 ; 20462069 (ISSN) ; Akhavan, O ; Tayyebi, A ; Rahighi, R ; Mohammadzadeh, M ; Saligheh Rad, H. R ; Sharif University of Technology
Royal Society of Chemistry
2015
Abstract
Superparamagnetic iron oxide (SPIO) nanomaterials are widely used as magnetic resonance imaging (MRI) contrast agents (CAs). These CAs significantly shorten transverse relaxation time (T2 ) and so decrease the intensity of the T2 -weighted MRI (negative contrast imaging). However, the partial-volume effect is known to be one of the problems in negative contrast MRI. In this work, SPIO nanoparticles were modified by dextran and graphene oxide (GO) nanosheets to achieve a positive contrast MRI with high intensity. This modification resulted in shortening the longitudinal relaxation time (T1 ) of the SPIO nanoparticles (in addition to the T2 shortening)....