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myoglobin
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Direct electron transfer of myoglobin on CdO nanoparticles modified glassy carbon electrode
, Article International Journal of Electrochemical Science ; Volume 8, Issue 5 , 2013 , Pages 7345-7356 ; 14523981 (ISSN) ; kakavandi, Y. G ; Movassagh, A. A ; Nasereslami, S ; Mohseni, G ; Hajiosseinlo, A ; Sofimaryo, L ; Soleimani, R ; Akbari-dastjerdi, H ; Negahdary, M ; Sharif University of Technology
2013
Abstract
In this study, direct electron transfer of myoglobin (Mb) on cadmium oxide (CdO) nanoparticles modified glassy carbon electrode (GCE) was investigated. Prepared CdO nanoparticles were studied by X-Ray diffraction (XRD) and UV-visible absorption methods. All electrochemical studies were performed by cyclic voltammetry (CV) and a potentiostat device. The cyclic voltammogram of Mb/ CdO Nps/ GCE showed a couple of stable redox and oxidative peaks at -470 and -370 mV at scan rate of 50 mVs-1, respectively. The formal potential (Eo) of myoglobin was calculated as -(420 ± 3) mV. Direct electrode transfer led to design a biosensor for determination of hydrogen peroxide (H2O2). The sensor sensitivity...
Challenges and future prospects for the delivery of biologics: oral mucosal, pulmonary, and transdermal routes
, Article AAPS Journal ; Volume 19, Issue 3 , 2017 , Pages 652-668 ; 15507416 (ISSN) ; Fathe, K. R ; Brunaugh, A ; Ferrati, S ; Li, S ; Montenegro Nicolini, M ; Mousavikhamene, Z ; McConville, J. T ; Prausnitz, M. R ; Smyth, H. D. C ; Sharif University of Technology
Springer New York LLC
2017
Abstract
Biologic products are large molecules such as proteins, peptides, nucleic acids, etc., which have already produced many new drugs for clinical use in the last decades. Due to the inherent challenges faced by biologics after oral administration (e.g., acidic stomach pH, digestive enzymes, and limited permeation through the gastrointestinal tract), several alternative routes of administration have been investigated to enable sufficient drug absorption into systemic circulation. This review describes the buccal, sublingual, pulmonary, and transdermal routes of administration for biologics with relevant details of the respective barriers. While all these routes avoid transit through the...