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    Feedback control of the neuro-musculoskeletal system in a forward dynamics simulation of stair locomotion [electronic resource]

    , Article Proc. of IMechE Part H: Journal of Engineering in Medicine ; 2009, Vol. 223, No. 6, pp. 663-675 Journal of NeuroEngineering and Rehabilitation ; Volume 11, Issue 1, 30 April 2014, Article number 78 Selk Ghafari, A. (Ali) ; Meghdari, Ali ; Vossough, Gholam Reza ; Sharif University of Technology
    Abstract
    The aim of this study is to employ feedback control loops to provide a stable forward dynamics simulation of human movement under repeated position constraint conditions in the environment, particularly during stair climbing. A ten-degrees-of-freedom skeletal model containing 18 Hill-type musculotendon actuators per leg was employed to simulate the model in the sagittal plane. The postural tracking and obstacle avoidance were provided by the proportional—integral—derivative controller according to the modulation of the time rate change of the joint kinematics. The stability of the model was maintained by controlling the velocity of the body's centre of mass according to the desired centre of... 

    Effects of motion segment simulation and joint positioning on spinal loads in trunk musculoskeletal models

    , Article Journal of Biomechanics ; 2017 ; 00219290 (ISSN) Ghezelbash, F ; Eskandari, A. H ; Shirazi Adl, A ; Arjmand, N ; El-Ouaaid, Z ; Plamondon, A ; Sharif University of Technology
    Elsevier Ltd  2017
    Abstract
    Musculoskeletal models represent spinal motion segments by spherical joints/beams with linear/nonlinear properties placed at various locations. We investigated the fidelity of these simplified models (i.e., spherical joints with/without rotational springs and beams considering nonlinear/linear properties) in predicting kinematics of the ligamentous spine in comparison with a detailed finite element (FE) model while considering various anterior-posterior joint placements. Using the simplified models with different joint offsets in a subject-specific musculoskeletal model, we computed local spinal forces during forward flexion and compared results with intradiscal pressure measurements. In... 

    A rigid thorax assumption affects model loading predictions at the upper but not lower lumbar levels

    , Article Journal of Biomechanics ; Volume 49, Issue 13 , 2016 , Pages 3074-3078 ; 00219290 (ISSN) Ignasiak, D ; Ferguson, S. J ; Arjmand, N ; Sharif University of Technology
    Elsevier Ltd 
    Abstract
    A number of musculoskeletal models of the human spine have been used for predictions of lumbar and muscle forces. However, the predictive power of these models might be limited by a commonly made assumption; thoracic region is represented as a single lumped rigid body. This study hence aims to investigate the impact of such assumption on the predictions of spinal and muscle forces. A validated thoracolumbar spine model was used with a flexible thorax (T1–T12), a completely rigid one or rigid with thoracic posture updated at each analysis step. The simulations of isometric forward flexion up to 80°, with and without a 20 kg hand load, were performed, based on the previously measured... 

    Effect of considering stability requirements on antagonistic muscle activities using a musculoskeletal model of the human lumbar spine

    , Article 2013 20th Iranian Conference on Biomedical Engineering, ICBME 2013 ; 2013 , Pages 260-264 Hajihoseinali, M ; Nickpour, H ; Arjmand, N ; Farahmand, F ; Sharif University of Technology
    2013
    Abstract
    The recruitment pattern of trunk muscles is determined using a three-dimensional model of the spine with two joints and six symmetric pairs of muscles in which both equilibrium and stability requirements are satisfied. Model predictions are verified using Anybody Modeling System (AMS) and Abaqus. The model is used to test the hypothesis that antagonistic muscle activities are necessary for the spinal stability. The model with stability constraints predicts muscle activities greater than those predicted without stability consideration. In agreement with experimental data, the stability-based model predicts antagonistic muscle activities. It is shown that spinal stability increases with trunk... 

    A model for flexi-bar to evaluate intervertebral disc and muscle forces in exercises

    , Article Medical Engineering and Physics ; Volume 38, Issue 10 , 2016 , Pages 1076-1082 ; 13504533 (ISSN) Abdollahi, M ; Nikkhoo, M ; Ashouri, S ; Asghari, M ; Parnianpour, M ; Khalaf, K ; Sharif University of Technology
    Elsevier Ltd  2016
    Abstract
    This study developed and validated a lumped parameter model for the FLEXI-BAR, a popular training instrument that provides vibration stimulation. The model which can be used in conjunction with musculoskeletal-modeling software for quantitative biomechanical analyses, consists of 3 rigid segments, 2 torsional springs, and 2 torsional dashpots. Two different sets of experiments were conducted to determine the model's key parameters including the stiffness of the springs and the damping ratio of the dashpots. In the first set of experiments, the free vibration of the FLEXI-BAR with an initial displacement at its end was considered, while in the second set, forced oscillations of the bar were... 

    Obesity and spinal loads; a combined MR imaging and subject-specific modeling investigation

    , Article Journal of Biomechanics ; 2017 ; 00219290 (ISSN) Akhavanfar, M. H ; Kazemi, H ; Eskandari, A. H ; Arjmand, N ; Sharif University of Technology
    Abstract
    Epidemiological studies have identified obesity asa possible risk factor for low back disorders. Biomechanical models can help test such hypothesis and shed light on the mechanism involved. A novel subject-specific musculoskeletal-modelling approach is introduced to estimate spinal loads during static activities in five healthy obese (BMI>30kg/m2) and five normal-weight (20

    Obesity and spinal loads; a combined MR imaging and subject-specific modeling investigation

    , Article Journal of Biomechanics ; Volume 70 , March , 2018 , Pages 102-112 ; 00219290 (ISSN) Akhavanfar, M. H ; Kazemi, H ; Eskandari, A. H ; Arjmand, N ; Sharif University of Technology
    Elsevier Ltd  2018
    Abstract
    Epidemiological studies have identified obesity as a possible risk factor for low back disorders. Biomechanical models can help test such hypothesis and shed light on the mechanism involved. A novel subject-specific musculoskeletal-modelling approach is introduced to estimate spinal loads during static activities in five healthy obese (BMI > 30 kg/m2) and five normal-weight (20 < BMI < 25 kg/m2) individuals. Subjects underwent T1 through S1 MR imaging thereby measuring cross-sectional-area (CSA) and moment arms of trunk muscles together with mass and center of mass (CoM) of T1-L5 segments. MR-based subject-specific models estimated spinal loads using a kinematics/optimization-driven... 

    Control of different FEM based musculoskeletal models of human lumbar spine under different loading conditions using optimization method

    , Article 8th Biennial ASME Conference on Engineering Systems Design and Analysis, ESDA2006, Torino, 4 July 2006 through 7 July 2006 ; Volume 2006 , 2006 ; 0791837793 (ISBN); 9780791837795 (ISBN) Kiapour, A ; Parnianpour, M ; Shirazi Adl, A ; Sharif University of Technology
    American Society of Mechanical Engineers  2006
    Abstract
    In this study the effects of using different musculoskeletal models on load-displacement behavior of FE models of the human lumbar spine under external loads and moments have been analyzed in terms of equilibrium and clinical stability. A simplified and a complex architecture of muscles have been integrated to FE based models of lumbar spine and were loaded to simulate the load carrying behavior of human lumbar spine in flexion, extension and lateral bending. The displacement values as well as muscle forces have been computed and compared in both cases using optimization methods with different cost functions. The models showed similar kinematics in pure flexion but the simplified model... 

    Effects of motion segment simulation and joint positioning on spinal loads in trunk musculoskeletal models

    , Article Journal of Biomechanics ; Volume 70 , March , 2018 , Pages 149-156 ; 00219290 (ISSN) Ghezelbash, F ; Eskandari, A. H ; Shirazi Adl, A ; Arjmand, N ; El-Ouaaid, Z ; Plamondon, A ; Sharif University of Technology
    Elsevier Ltd  2018
    Abstract
    Musculoskeletal models represent spinal motion segments by spherical joints/beams with linear/nonlinear properties placed at various locations. We investigated the fidelity of these simplified models (i.e., spherical joints with/without rotational springs and beams considering nonlinear/linear properties) in predicting kinematics of the ligamentous spine in comparison with a detailed finite element (FE) model while considering various anterior-posterior joint placements. Using the simplified models with different joint offsets in a subject-specific musculoskeletal model, we computed local spinal forces during forward flexion and compared results with intradiscal pressure measurements. In... 

    Adaptive optimal multi-critic based neuro-fuzzy control of MIMO human musculoskeletal arm model

    , Article Neurocomputing ; Volume 173 , 2016 , Pages 1529-1537 ; 09252312 (ISSN) Balaghi, M. H. E ; Vatankhah, R ; Broushaki, M ; Alasty, A ; Sharif University of Technology
    Elsevier 
    Abstract
    Human bodies use the electrical currents to make the muscles move. Disconnection of the electrical signals between the brain and the muscles as a result of spinal cord injuries, causes paralysis below the level of injury. Functional electrical stimulation (FES) is used to stimulate the peripheral nerves of the disabled limbs. The level of these electrical signals should be selected so that the desired tasks are done successfully. Applying the appropriate controller which can result a human like behaviour and the accomplishment of the desired tasks has become a significant research area. In this paper, the multi-input multi-output (MIMO) musculoskeletal model of human arm with six muscles is... 

    Prediction of the lower extremity muscle forces during stair ascent and descent

    , Article 2008 Proceedings of the ASME International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, DETC 2008, 3 August 2008 through 6 August 2008, New York City, NY ; Volume 3, Issue PART B , 2009 , Pages 1589-1593 ; 9780791843253 (ISBN) Selk Ghafari, A ; Meghdari, A ; Vossoughi, G. R ; Design Engineering Division, ASME ; Sharif University of Technology
    2009
    Abstract
    An inverse dynamics musculoskeletal model of the lower extremity was combined with an optimization technique to estimate individual muscular forces and powers during stair ascent and descent. Eighteen Hill-type musculotendon actuators per leg were combined into the eleven functional muscle groups based on anatomical classification to drive the model in the sagittal plane. Simulation results illustrate the major functional differences in plantar flexors of the ankle and extensors of the knee and hip joints during ascent and descent. The results of this study not only could be employed to evaluate the rehabilitation results in the elderly but also could be used to design more anthropometric... 

    Prediction of the lower extremity muscle forces during stair ascent and descent

    , Article ASME 2008 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE2008, Brooklyn, NY, 3 August 2008 through 6 August 2008 ; Volume 3, Issue PARTS A AND B , July , 2008 , Pages 1589-1593 ; 9780791843277 (ISBN) Selk Ghafari, A ; Meghdari, A ; Vossoughi, G. R ; Sharif University of Technology
    2008
    Abstract
    An inverse dynamics musculoskeletal model of the lower extremity was combined with an optimization technique to estimate individual muscular forces and powers during stair ascent and descent. Eighteen Hill-type musculotendon actuators per leg were combined into the eleven functional muscle groups based on anatomical classification to drive the model in the sagittal plane. Simulation results illustrate the major functional differences in plantar flexors of the ankle and extensors of the knee and hip joints during ascent and descent. The results of this study not only could be employed to evaluate the rehabilitation results in the elderly but also could be used to design more anthropometric... 

    Obesity and obesity shape markedly influence spine biomechanics: a subject-specific risk assessment model

    , Article Annals of Biomedical Engineering ; Volume 45, Issue 10 , 2017 , Pages 2373-2382 ; 00906964 (ISSN) Ghezelbash, F ; Shirazi Adl, A ; Plamondon, A ; Arjmand, N ; Parnianpour, M ; Sharif University of Technology
    Abstract
    Underlying mechanisms of obesity-related back pain remain unexplored. Thus, we aim to determine the effect of obesity and its shapes on the spinal loads and the associated risks of injury. Obesity shapes were initially constructed by principal component analysis based on datasets on 5852 obese individuals. Spinal loads, cycles to vertebral failure and trunk stability margin were estimated in a subject-specific trunk model taking account of personalized musculature, passive ligamentous spine, obesity shapes, segmental weights, spine kinematics and bone mineral density. Three obesity shapes (mean and extreme abdominal circumferences) at three body weights (BWs) of 86, 98 and 109 kg were... 

    A novel approach towards control of exoskeletal systems as an assistive device for human's upper extremity

    , Article JICTEE 2014 - 4th Joint International Conference on Information and Communication Technology, Electronic and Electrical Engineering ; 2014 Ghassemi, M ; Jahed, M ; Sharif University of Technology
    Abstract
    With increasing importance of exoskeletons as rehabilitation apparatuses, suitable and delicate control strategies has received much attention. In order to control the exoskeleton, there should be a complete understanding of torques produced by the limb itself which makes the musculoskeletal modeling of the limb essential but also complex. In addition, the musculoskeletal model can be used to discover the user's desired movement to control the exoskeleton. In this paper a complete musculoskeletal model for the elbow with two degrees of freedom is developed and simulated. Next the model is used to determine user's desired movement. Finally based on this evaluation, an exoskeleton model is... 

    Design of an optimum torque actuator for augmenting lower extremity exoskeletons in biomechanical framework

    , Article 2011 IEEE International Conference on Robotics and Biomimetics, ROBIO 2011 ; 2011 , Pages 1979-1983 ; 9781457721373 (ISBN) Safavi, S ; Ghafari, A. S ; Meghdari, A ; Sharif University of Technology
    Abstract
    This research presents virtual prototyping and performance evaluation of a series elastic torque actuator developed for augmenting lower extremity exoskeletal systems employing biomechanical framework. For this purpose, experimental kinematical data of the lower extremity were collected for walking and backpack load carrying. Forward dynamics simulation of the movements under investigation is performed in a biomechanical framework consisting of a musculoskeletal model with ten degrees-of-freedom actuated by eighteen Hill-type musculotendon actuators per leg to perform the muscle functional analysis. Muscle torque analysis results employed for optimal design and selection of components in the... 

    Efficient design of a torque actuator for lower extremity exoskeleton based on muscle function analysis

    , Article 2011 International Conference on Mechatronics and Materials Processing, ICMMP 2011, Guangzhou, 18 November 2011 through 20 November 2011 ; Volume 328-330 , 2011 , Pages 1041-1044 ; 10226680 (ISSN) ; 9783037852385 (ISBN) Safavi, S ; Selk Ghafari, A ; Meghdari, A ; Guangzhou University ; Sharif University of Technology
    2011
    Abstract
    Several lower extremity exoskeletal systems have been developed for augmentation purpose. Common actuators, have important drawbacks such as complexity, and poor torque capacities. The main scope of this research is to propose a series elastic actuator for lower extremity exoskeletal system which was designed based on muscle functional analysis. For this purpose, a biomechanical framework consisting of a musculoskeletal model with ten degrees-of-freedom actuated by eighteen Hill-type musculotendon actuators per leg is utilized to perform the muscle functional analysis for common daily human activities. The simulation study illustrated functional differences between flexor and extensor... 

    Variations in trunk muscle activities and spinal loads following posterior lumbar surgery: A combined in vivo and modeling investigation

    , Article Clinical Biomechanics ; Volume 30, Issue 10 , 2015 , Pages 1036-1042 ; 02680033 (ISSN) Jamshidnejad, S ; Arjmand, N ; Sharif University of Technology
    Abstract
    Background Iatrogenic injuries to paraspinal muscles during posterior lumbar surgery cause a reduction in their contractile cross-sectional area and thus presumably their postoperative activation. This study investigates the effect of such intraoperative injuries on postoperative patterns of muscle activations and spinal loads during various activities using a combined modeling and in vivo MR imaging approach. Methods A three-dimensional, multi-joint, musculoskeletal model was used to estimate pre- and postoperative muscle forces and spinal loads under various activities in upright and flexed postures. According to our in vivo pre- and postoperative (∼ 6 months) measurements in six patients... 

    Effects of sex, age, body height and body weight on spinal loads: Sensitivity analyses in a subject-specific trunk musculoskeletal model

    , Article Journal of Biomechanics ; Volume 49, Issue 14 , 2016 , Pages 3492-3501 ; 00219290 (ISSN) Ghezelbash, F ; Shirazi Adl, A ; Arjmand, N ; El Ouaaid, Z ; Plamondon, A ; Meakin, J. R ; Sharif University of Technology
    Elsevier Ltd 
    Abstract
    Subject-specific parameters influence spinal loads and the risk of back disorders but their relative effects are not well understood. The objective of this study is to investigate the effects of changes in age (35–60 years), sex (male, female), body height (BH: 150–190 cm) and body weight (BW: 50–120 kg) on spinal loads in a full-factorial simulation using a personalized (spine kinematics, geometry, musculature and passive properties) kinematics driven musculoskeletal trunk finite element model. Segmental weight distribution (magnitude and location along the trunk) was estimated by a novel technique to accurately represent obesity. Five symmetric sagittal loading conditions were considered,... 

    A combined passive and active musculoskeletal model study to estimate L4-L5 load sharing

    , Article Journal of Biomechanics ; 2017 ; 00219290 (ISSN) Azari, F ; Arjmand, N ; Shirazi Adl, A ; Rahimi Moghaddam, T ; Sharif University of Technology
    Elsevier Ltd  2017
    Abstract
    A number of geometrically-detailed passive finite element (FE) models of the lumbar spine have been developed and validated under in vitro loading conditions. These models are devoid of muscles and thus cannot be directly used to simulate in vivo loading conditions acting on the lumbar joint structures or spinal implants. Gravity loads and muscle forces estimated by a trunk musculoskeletal (MS) model under twelve static activities were applied to a passive FE model of the L4-L5 segment to estimate load sharing among the joint structures (disc, ligaments, and facets) under simulated in vivo loading conditions. An equivalent follower (FL), that generates IDP equal to that generated by muscle... 

    Trunk musculoskeletal response in maximum voluntary exertions: a combined measurement-modeling investigation

    , Article Journal of Biomechanics ; 2017 ; 00219290 (ISSN) Ghezelbash, F ; El Ouaaid, Z ; Shirazi Adl, A ; Plamondon, A ; Arjmand, N ; Sharif University of Technology
    Abstract
    Maximum voluntary exertion (MVE) tasks quantify trunk strength and maximal muscle electromyography (EMG) activities with both clinical and biomechanical implications. The aims here are to evaluate the performance of an existing trunk musculoskeletal model, estimate maximum muscle stresses and spinal forces, and explore likely differences between males and females in maximum voluntary exertions. We, therefore, measured trunk strength and EMG activities of 19 healthy right-handed subjects (9 females and 10 males) in flexion, extension, lateral and axial directions. MVEs for all subjects were then simulated in a subject-specific trunk musculoskeletal model, and estimated muscle activities were...