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muscle-derived-cell
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Chitosan-gelatin sheets as scaffolds for muscle tissue engineering
, Article Artificial Cells, Nanomedicine and Biotechnology ; Volume 43, Issue 2 , Nov , 2015 , Pages 124-132 ; 21691401 (ISSN) ; Mashayekhan, S ; Nazaripouya, A ; Naji, M ; Hunkeler, D ; Rajabi Zeleti, S ; Sharifiaghdas, F ; Sharif University of Technology
Informa Healthcare
2015
Abstract
Hydrogels made of natural polymers [chitosan (CS) and gelatin (G)] have been prepared having mechanical properties similar to those of muscle tissues. In this study, the effect of polymer concentration and scaffold stiffness on the behavior of seeded muscle-derived cells (MDCs) on the CS-G hydrogel sheets has been evaluated. Both variables were found to be important in cell viability. Viability was assessed by observation of the cell morphology after 1 day as well as a 14-day MTT assay. The CS-G hydrogels were characterized using Fourier transform infrared (FTIR) analysis, which revealed evidences of strong intermolecular interactions between CS and G. Hydrogel samples with intermediate...