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    A comparative overview of epigenomic profiling methods

    , Article Frontiers in Cell and Developmental Biology ; Volume 9 , 2021 ; 2296634X (ISSN) Mehrmohamadi, M ; Sepehri, M. H ; Nazer, N ; Norouzi, M. R ; Sharif University of Technology
    Frontiers Media S. A  2021
    Abstract
    In the past decade, assays that profile different aspects of the epigenome have grown exponentially in number and variation. However, standard guidelines for researchers to choose between available tools depending on their needs are lacking. Here, we introduce a comprehensive collection of the most commonly used bulk and single-cell epigenomic assays and compare and contrast their strengths and weaknesses. We summarize some of the most important technical and experimental parameters that should be considered for making an appropriate decision when designing epigenomic experiments. © Copyright © 2021 Mehrmohamadi, Sepehri, Nazer and Norouzi