Sharif Digital Repository

Being the second cause of mortality across the globe, there is now a persistent effort to establish new cancer medication and therapies. Any accomplishment in treating cancers entails the existence of accurate identification systems empowering the early diagnosis. Recent studies indicate CTCs’ potential in cancer prognosis as well as therapy monitoring. The chief shortcoming with CTCs is that they are exceedingly rare cells in their clinically relevant concentration. Here, we simulated a microfluidic construct devised for immunomagnetic separation of the particles of interest from the background cells. This separation unit is integrated with a mixer subunit. The mixer is envisioned for... 

Magnetically actuated droplet manipulation offers a promising tool for biomedical and engineering applications, such as drug delivery, biochemistry, sample handling in lab-on-chip devices and tissue engineering. In this study, characteristics of an adjustable alternating magnetic field generated by a magnetic coil for droplet manipulation was investigated which enables more control on droplet transport, and it can be considered as a suitable alternative for moving magnets or an array of micro-coils. By adjusting the magnetic flux density, the duty cycle and applied magnetic frequency, the manipulation of water-based ferrofluid droplets with a bio-compatible surfactant for different volumes...