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metronidazole
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Heterogeneous catalytic ozonation by Nano-MgO is better than sole ozonation for metronidazole degradation, toxicity reduction, and biodegradability improvement
, Article Desalination and Water Treatment ; Volume 57, Issue 35 , 2016 , Pages 16435-16444 ; 19443994 (ISSN) ; Bahrami Asl, F ; Farzadkia, M ; Esrafili, A ; Salahshour Arian, S ; Khazaei, M ; Dadban Shahamat, Y ; Zeynalzadeh, D ; Sharif University of Technology
Taylor and Francis Inc
2016
Abstract
Abstract: In the current paper, the removal efficiency of metronidazole (MNZ) using a catalytic ozonation process (COP) in the presence of magnesium oxide nanocrystals, as a catalyst, was investigated in deionized water and compared with a sole ozonation process (SOP). The influence of several operational factors on both removal processes was evaluated: solution pH, MgO dosage, initial MNZ concentration, and reaction time. Biodegradability improvement, mineralization rate, oxidation intermediates, and toxicity were also studied for the COP. The results showed that MgO nanocrystals accelerated MNZ removal compared to the SOP. The optimum pH for both SOP and COP was obtained at 10 and optimum...
Highly sensitive 3D gold nanotube ensembles: Application to electrochemical determination of metronidazole
, Article Electrochimica Acta ; Volume 106 , 2013 , Pages 288-292 ; 00134686 (ISSN) ; Ghorbani, M ; Ghalkhani, M ; Vossoughi, M ; Dolati, A ; Sharif University of Technology
2013
Abstract
Three-dimensional gold nanoelectrode ensembles (3D GNE) have proven to be promising nanoelectrodes by representing much higher sensitivity compared to both their 2D nanostructures and bulk counterparts. The sensitivity of 3D gold nanotubes (GNTs) fabricated through electrodeposition inside the pores of polycarbonate templates, was examined toward metronidazole (MTZ) as one of their pharmaceutical applications. The electrochemical behavior of MTZ at the 3D GNT-modified electrode was discussed in detail through cyclic voltammetry (CV) which suggested an irreversible reduction of nitro group to the corresponding hydroxylamine and a subsequently reversible redox peak for the corresponding...
QSRR study of psychiatric drugs using classification and regression trees combined with adaptive neuro-fuzzy inference system
, Article QSAR and Combinatorial Science ; Volume 27, Issue 6 , 2008 , Pages 729-739 ; 1611020X (ISSN) ; Shahbazikhah, P ; Ghadiri Bidhendi, A ; Sharif University of Technology
2008
Abstract
A new Quantitative Structure-Retention Relationship (QSRR) approach was carried out for prediction of gas-liquid retention times of 124 psychiatric drugs in whole blood on fused-silica capillary column coated with crosslinked methylsilicone with nitrogen-phosphorus detection. After screening the descriptors, a total of 699 topological, geometric, and electronic descriptors (zero-to three-dimensional) representing various structural characteristics were calculated for each molecule in the dataset. Combined method of Classification and Regression Tree (CART) as a feature selection method for the extraction of four relevant descriptors and Adaptive Neuro-Fuzzy Inference System (ANFIS) as a...