Sharif Digital Repository

Presented in this paper are a method, named the Dynamic Rule Prediction (DRP), which predicts the behavior of a system and its application in designing a controller. The aim of the study is to overcome some of the limitations and shortcoming of the other modeling methods. The effectiveness of this method is verified. The controller based on DRP possesses two main features. It can control the system without any prior knowledge of the controlled plant. It is, also, superior as its high-speed prediction. This paper focuses on the robot manipulator controllers and applications of this approach in it  

In this paper, an extended approach to the nonlinear DMC algorithm is proposed, which can handle constrained and MIMO systems under some defined conditions. This extension also admits higher control horizon, M and prediction horizon, P that are required to increase the performance of the controller in the most practical applications. Simulation results of the proposed method in the control of a stirred tank reactor with 2 inputs, 2 outputs nonlinear model and also a power unit nonlinear model with 3 inputs, 3 outputs are presented to illustrate effectiveness of the method and its justification. © 2005 Elsevier Ltd. All rights reserved  

Adaptive Model Predictive Transmission Control Protocol (AMP-TCP) as a new TCP delay-based congestion control algorithm is introduced. Both aspects of design and implementation of the algorithm are described using simulations on the ns-2 network simulator. The design stage is composed of two steps. First, a recursive system identification approach is proposed to capture the network delay dynamics from TCP source view. Second, the proposed modeling is employed to develop an adaptive model predictive TCP congestion control strategy in the absence of any explicit congestion notification. The characteristics and performance of AMP-TCP are investigated using several network simulations. Finally a... 

Higher reactive oxygen species (ROS) levels in cancer cells than normal cells have long been recognized, which makes cancer cells more susceptible to excess ROS. Thus oxidation (also called pro-oxidant) therapy has been explored as new cancer therapy regimens. To produce additional ROS, e.g. H2O2 in situ within tumor, we encapsulated glucose oxidase in chitosan-coated alginate-calcium microspheres (GOX-MS) for locoregional treatment and demonstrated its efficacy against cancer cells in vitro and in vivo. Owing to the complex biological functions of ROS, the production rate and amount of H2O2 are critical to achieve therapeutic benefits without causing normal tissue toxicity. This work was... 

This paper presents for the first time a mathematical model for a mechanism of controlled drug release involving both ion exchange and transient counter diffusion of a drug and counterions. Numerical analysis was conducted to study the effect of different factors on drug release kinetics including environmental condition, material properties, and design parameters. The concentration profiles of counterions and drug species, the moving front of ion exchange, and three distinct regions inside a microsphere, namely unextracted region, ion-exchange region and drug diffusion region, were revealed by model prediction. The numerical results indicated that the rate of drug release increased with an... 

Through the activation process of T cells, actin filaments move from the cell periphery toward the cell center. The moving filaments engage with T cell receptors and thus contribute to transportation of the signaling molecules. To study the connection between the moving actin filaments and T cell receptors, an experiment available in the literature has measured filaments flow velocity passing over a region of confined clusters of receptors. It shows that flow velocity decreases in the proximity of the receptors, and then regains its normal value after traversing the region, suggesting a dissipative friction-like connection. In this work, we develop a minimal theoretical model to re-examine... 

This study presents a novel statistical volume element (SVE) for micromechanical modeling of the white matter structures, with histology-informed randomized distribution of axonal tracts within the extracellular matrix. The model was constructed based on the probability distribution functions obtained from the results of diffusion tensor imaging as well as the histological observations of scanning electron micrograph, at two structures of white matter susceptible to traumatic brain injury, i.e. corpus callosum and corona radiata. A simplistic representative volume element (RVE) with symmetrical arrangement of fully alligned axonal fibers was also created as a reference for comparison. A...