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magnetophoresis
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High throughput solution exchange of microparticles using magnetophoresis in curved microchannels
, Article 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017, 22 October 2017 through 26 October 2017 ; 2020 , Pages 1324-1325 ; Zareian, S ; Rezai, P ; The Chemical and Biological Microsystems Society (CBMS) ; Sharif University of Technology
Chemical and Biological Microsystems Society
2020
Abstract
A novel method involving focusing of magnetic particles at the inner wall of a curved microchannel and secondary Dean flow-based exchange of their fluid was investigated. Solution exchange occurred in a hybrid microchip at very high throughput and with unprecedented solution exchange and particle isolation efficiencies of 99.2% and 90%, respectively. © 17CBMS-0001
Three-dimensional Simulation of Circulating Tumor Cells Magnetic Isolation Using a Viscoelastic-based Ferrofluid Solution
, M.Sc. Thesis Sharif University of Technology ; Saeedi, Mohammad Saeed (Supervisor)
Abstract
Nowadays cancer is the second major cause of death in the world after cardiovascular diseases and scientists and researchers are making considerable efforts to fight it. Detection and isolation of circulating tumor cells in the blood is of paramount importance as it can be further used to measure the disease severity as well as efficacy of chemical drugs. Magnetophoresis has attracted researchers because of its simplicity, high effectiveness and non-invasiveness. Microfluidic systems have a high potential for implementing conventional biological methods in a microscale for detection, separation and incubation of CTCs, and they also lead to reduction in costs and required samples. Prior to...
Investigation of a two-step device implementing magnetophoresis and dielectrophoresis for separation of circulating tumor cells from blood cells
, Article Engineering in Life Sciences ; Volume 20, Issue 7 , 2020 , Pages 296-304 ; Yazdani, A ; Saghafifar, F ; Sharif University of Technology
Wiley-VCH Verlag
2020
Abstract
Identifying tumor cells from a pool of other cells has always been an appealing topic for different purposes. The objective of this study is to discriminate circulating tumor cells (CTCs) from blood cells for diagnostic purposes in a novel microfluidic device using two active methods: magnetophoresis and dielectrophoresis. The most specific feature of this device is the differentiation of CTCs without labeling them in order to achieve a more reliable and less complicated method. This device was analyzed and evaluated using finite element method. Four cell lines are separated in this device containing red blood cells, platelets, white blood cells, and CTCs. Primarily, red blood cells and...
Investigation of a Novel Microfluidic Device for Label-Free Ferrohydrodynamic Cell Separation on a Rotating Disk
, Article IEEE Transactions on Biomedical Engineering ; Volume 67, Issue 2 , 2020 , Pages 372-378 ; Besanjideh, M ; Sharif University of Technology
IEEE Computer Society
2020
Abstract
Negative magnetophoresis is a novel and attractive method for continuous microparticle sorting inside a magnetic medium. In this method, diamagnetic particles are sorted based on their sizes using magnetic buoyancy force and without any labeling process. Although this method provides some attractive features, such as low-cost fabrication and ease of operation, there are some obstacles that adversely affect its performance, especially for biological applications. Most types of magnetic media, such as ferrofluids, are not biocompatible, and the time-consuming process of sample preparation can be threatening to the viability of the cells within the sample. Furthermore, in this method, both the...