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left-coronary-artery
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High precision invasive FFR, low-cost invasive iFR, or non-invasive CFR?: optimum assessment of coronary artery stenosis based on the patient-specific computational models
, Article International Journal for Numerical Methods in Biomedical Engineering ; Volume 36, Issue 10 , 2020 ; Nikmaneshi, M. R ; Firoozabadi, B ; Pakravan, H. A ; Ahmadi Tafti, S. H ; Afshin, H ; Sharif University of Technology
Wiley-Blackwell
2020
Abstract
The objective of this paper is to apply computational fluid dynamic (CFD) as a complementary tool for clinical tests to not only predict the present and future status of left coronary artery stenosis but also to evaluate some clinical hypotheses. In order to assess the present status of the coronary artery stenosis severity, and thereby selecting the most appropriate type of treatment for each patient, fractional flow reserve (FFR), instantaneous wave free-ratio (iFR), and coronary flow reserve (CFR) are calculated. To examine FFR, iFR, and CFR results, the effect of geometric features of stenoses, including diameter reduction (%), lesion length (LL), and minimum lumen diameter (MLD), is...
Primary stenosis progression versus secondary stenosis formation in the left coronary bifurcation: a mechanical point of view
, Article Biocybernetics and Biomedical Engineering ; Volume 39, Issue 1 , 2019 , Pages 188-198 ; 02085216 (ISSN) ; Pakravan, H. A ; Saidi, M. S ; Firoozabadi, B ; Sharif University of Technology
Elsevier Sp. z o.o
2019
Abstract
Biomechanical forces and hemodynamic factors influence the blood flow and the endothelial cells (ECs) morphology. These factors behave differently beyond the coronary artery stenosis. In the present study, unsteady blood flow in the left coronary artery (LCA) and its atherosclerotic bifurcating vessels, left anterior descending (LAD) and left circumflex (LCX) arteries, were numerically simulated to investigate the risk of plaque length development and secondary plaque formation in the post-stenotic areas. Using fluid–structure interaction (FSI) model, compliance of arterial wall and vessel curvature variations due to cardiac motion were considered. The arteries included plaques at the...
Primary stenosis progression versus secondary stenosis formation in the left coronary bifurcation: a mechanical point of view
, Article Biocybernetics and Biomedical Engineering ; Volume 39, Issue 1 , 2019 , Pages 188-198 ; 02085216 (ISSN) ; Pakravan, H. A ; Saidi, M. S ; Firoozabadi, B ; Sharif University of Technology
Elsevier Sp. z o.o
2019
Abstract
Biomechanical forces and hemodynamic factors influence the blood flow and the endothelial cells (ECs) morphology. These factors behave differently beyond the coronary artery stenosis. In the present study, unsteady blood flow in the left coronary artery (LCA) and its atherosclerotic bifurcating vessels, left anterior descending (LAD) and left circumflex (LCX) arteries, were numerically simulated to investigate the risk of plaque length development and secondary plaque formation in the post-stenotic areas. Using fluid–structure interaction (FSI) model, compliance of arterial wall and vessel curvature variations due to cardiac motion were considered. The arteries included plaques at the...
Computational investigation of stenosis in curvature of coronary artery within both dynamic and static models
, Article Computer Methods and Programs in Biomedicine ; Volume 185 , 2020 ; Momeni Larimi, M ; Hassanzadeh Afrouzi, H ; Moshfegh, A ; Toghraie, D ; Javadzadegan, A ; Rostami, S ; Sharif University of Technology
Elsevier Ireland Ltd
2020
Abstract
Background and Objective: Blood flow variation during cardiac cycle is the main mechanism of atherosclerotic development which is dependent on. Methods: The present work mainly tends to investigate stenosis effect in dynamic curvature of coronary artery. This paper presents numerical investigations on wall shear stress profiles in three-dimensional pulsatile flow through curved stenotic coronary arteries for both static and dynamic model. In order to do so, three-dimensional models related to the curved arteries with two degrees of stenosis (30% and 50%). Results: Lower amount of wall shear stress is found near the inner wall of artery distal to the plaque region (stenosis) and in both...