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Fluids Flow Simulation in the Cell Influenced the Focal Adhesions
, Ph.D. Dissertation Sharif University of Technology ; Firoozabadi, Bahar (Supervisor) ; saidi, Mohammad said (Co-Advisor)
Abstract
In the present thesis, intracellular fluid flows have investigated for study cell motions. It is due to firmly relation between the cell motion and these flows. Generally, the cell firstly adheres to a surface, then, moves forward with the effects of the internal fluid flows. In this study, the cell structure is invided to two general parts; the front part of the cell and the cell body. The front part of the cell plays a essential roles in the cell motion, however, the cell body is considered as a extra cargo that is carried by the front of the cell. Therefor, in the present modellings, the front part is only considered. Here, using four different models for the front part of the cell, many...
Studies of the Interaction between Actins Flow and Cell Adhesion Nucleation in Macro-and Micro-scale
,
Ph.D. Dissertation
Sharif University of Technology
;
Firouzabadi, Bahar
(Supervisor)
;
Saeedi, Mohammad Saeed
(Supervisor)
Abstract
The network of actin filaments is one of the three elements of the Cytoskeleton and plays a role in cell shape and migration. The actin network is dynamic; it (de)polymerizes, and in migrating and spreading cells, it is in a retrograde motion from the cell periphery toward cell nucleus. Adhesion points, which link the cytoskeleton to the extracellular matrix, interact with the actin retrograde flow. Actin filaments can be identified in two distinct regions in which their structure, flow velocity, driving force and size of the adhesions are different; the outer region is called Lamellipodium and the inner one Lamellum. In macro scale and regarding spreading cells, considering adhesions...
Theoretical modeling of actin-retrograde-flow passing clusters of confined T cell receptors
, Article Mathematical Biosciences ; Volume 283 , 2017 , Pages 1-6 ; 00255564 (ISSN) ; Firoozabadi, B ; Saidi, M. S ; Sharif University of Technology
Elsevier Inc
2017
Abstract
Through the activation process of T cells, actin filaments move from the cell periphery toward the cell center. The moving filaments engage with T cell receptors and thus contribute to transportation of the signaling molecules. To study the connection between the moving actin filaments and T cell receptors, an experiment available in the literature has measured filaments flow velocity passing over a region of confined clusters of receptors. It shows that flow velocity decreases in the proximity of the receptors, and then regains its normal value after traversing the region, suggesting a dissipative friction-like connection. In this work, we develop a minimal theoretical model to re-examine...