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Spirocycles have been employed both as core structures and appended to the periphery of molecules in drug discovery. The major advantage that spirocycles offer as core structures is their inherent three-dimensional nature and concomitant ability to project functionality in all three dimensions. Spirocycles have been employed both as core structures and appended to the periphery of molecules in drug discovery. The major advantage that spiro cyclesoffer as core structures is their inherent three-dimensional nature and concomitant ability to project functionality in all three dimensions. However, to take full advantage of spirocycles, the ability to control stereochemistry at multiple positions... 

Spirooxindole compounds are naturally occurring compounds and have significant biological activities due to their unique spatial structure. Spirooxindole compounds, especially spiro oxindoles containing acyclic ring at C-3 position of oxindole, have high interaction capability with large productions. Therefore, these compounds are important in medicinal chemistry. The method used for the synthesis of spirooxindole compounds has been introduced. In general, for the synthesis of these compounds, isatin derivatives are used in 1 and 3 dipolar reactions in the presence of various solvents and catalysts. Due to the presence of quaternary spiro carbon with sp3 hybridization in the structure of...