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hyphenated-chromatography
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Development and Application of Independent Component Analysis Method for Evaluation of Complex Chromatographic Data
, M.Sc. Thesis Sharif University of Technology ; Parastar Shahri, Hadi (Supervisor)
Abstract
In recent years, chromatographic technique as one of the most important analytical techniques have been developed for the analysis of complex samples. Hyphenated chromatographic techniques such as liquid or gas chromatography combine separation and spectroscopic detection technique to exploit the advantages of both and they have attracted attention of chemists to analyze complex mixtures. However, inadequate separation challenges still exist especially in the analysis of complex samples. Therefore, two-dimensional chromatographic systems such as comprehensive two-dimensional gas chromatography-mass spectrometry (GC×GC-MS) have been proposed for the analysis of complex samples due to their...
Multivariate curve resolution-particle swarm optimization: A high-throughput approach to exploit pure information from multi-component hyphenated chromatographic signals
, Article Analytica Chimica Acta ; Volume 772 , 2013 , Pages 16-25 ; 00032670 (ISSN) ; Ebrahimi Najafabadi, H ; Jalali Heravi, M ; Sharif University of Technology
2013
Abstract
Multivariate curve resolution-particle swarm optimization (MCR-PSO) algorithm is proposed to exploit pure chromatographic and spectroscopic information from multi-component hyphenated chromatographic signals. This new MCR method is based on rotation of mathematically unique PCA solutions into the chemically meaningful MCR solutions. To obtain a proper rotation matrix, an objective function based on non-fulfillment of constraints is defined and is optimized using particle swarm optimization (PSO) algorithm. Initial values of rotation matrix are calculated using local rank analysis and heuristic evolving latent projection (HELP) method. The ability of MCR-PSO in resolving the chromatographic...